Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com     

Wenchao Ma  Jimmy de la Torre 《Educational Measurement》2019,38(2):114-115

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.  相似文献   

对民国档案文件级整理工作的思索     

陈晓敏 《山西档案》2006,(1):35-37

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。  相似文献   

Unique unto itself: The records of the Federal Bureau of Investigation 1908 to 1945     

John F. Fox Jr. 《Journal of Government Information》2004,30(4):470-481

This paper addresses several misunderstandings about the nature of the FBI's Central Records System. Although depicted in popular culture and much of FBI historiography as a tool for the Cold War suppression of American radicals, the FBI's records system grew out of Department of Justice systems already in place before J. Edgar Hoover became Director in 1924. The system grew in size and complexity according to the demands placed on it by the changing priorities of the FBI's criminal and intelligence missions, guided by a “progressive” drive for efficiency through centralization.  相似文献   

COUNTER R5的新特性及对图书馆的影响     

侯景丽 《图书馆杂志》2018,(12):46-55

COUNTER是规范网络化电子资源使用统计报告数据处理、审核和提交的国际化标准,是图书馆电子资源使用量统计和评估的核心要素。目前COUNTER已经发布了最新版本R5,了解R5的新特性及与之前版本的不同对于图书馆的电子资源统计工作具有重要意义。本文拟从COUNTERR5的报告设置、报告的指标类型、数据类型、访问类型和其他完善报告的属性来解析R5,同时介绍R5对SUSHI收割的影响、"持续维护"的概念、R5发布对图书馆的影响和R5实施的重要时间节点,同时也对R5较之R4的发展和不同进行了比较和分析。COUNTERR5的主要关注点是一致性、清晰性和简单性,较之COUNTERR4有了明显的完善,同时包含了持续的维护过程,允许对代码进行更新而不必再引入一个全新的版本,解决了版本升级会对供应商和图书馆带来的各种时间和人员成本的影响。  相似文献   

Rumours of Wars and Deeds of Emperors: Circulation of News and “Stories” about Non-Venetians in Early Medieval Venice*     

Luigi Andrea Berto 《Al-Masaq: Islam & the Medieval Mediterranean》2016,28(2):153-170

  相似文献   

社鼠、雷琼社鼠和针毛鼠染色体分类的研究   总被引：2，自引：0，他引：2  

江庆澜 《中山大学学报论丛》1995,(1)

社鼠、雷琼社鼠和针毛鼠都是山地栖息种类，它们染色体的2n数目和形态明显有别于同属的其他各种．体现出它们之间的亲缘关系较近，它们间的核型演化是通过罗伯逊易位和缺失途径，社鼠、雷琼社鼠和针毛鼠有着不同于属中其他种类的生态位，把它们另作一属会恰当些；社鼠和雷琼社鼠的地理分布有所不同．但染色体组型并不差异．认为它们间可能仅是毛色变异，而不存在两个亚种之分．  相似文献   

两次世界大战前后的亚欧关系探析     

余建华 《历史教学问题》2005,(2):4-8

20世纪初叶“亚洲的觉醒”革命风暴作为现代亚洲民族解放运动的序曲 ,对亚欧之间殖民地 (附庸国 )与宗主国的依附关系形成强有力冲击。两次世界大战更是对亚欧关系的演变产生决定性影响。如果说第一次世界大战大大削弱了欧洲对其亚洲殖民地的控制 ,那么第二次世界大战则成为欧洲殖民体系崩溃、亚洲民族新生的历史催化剂 ,使亚欧之间的不平等关系发生了根本性改变。此外二战期间亚欧大陆两端人民在反法西斯斗争中同仇敌忾、互助合作 ,则成为该时期亚欧关系的主要内容。  相似文献   

R~n上局部可积函数一个性质的推广     

韩振岭  王汝发 《赣南师范学院学报》1997,(6)

文［１］中王士林教授给出了一个有用的引理，本文将该引理进行推广，利用该引理为研究Ｌｉｔｌｅｗｏｏｄ—ｐａｌｅｙｇλ—函数和Ｌｕｓｉｎ面积积分函数提供了有力工具  相似文献   

浅析美国第二次世界大战残疾退伍军人福利政策     

曹景文 《遵义师范学院学报》2011,13(4):8-11,15

美国退伍军人是一个庞大的特殊群体,残疾退伍军人则是特殊中的特殊。在既享受国家基本退伍福利的同时,二战残疾退伍军人还享受针对身体残疾设计的收入维持性福利、就业优待、医疗福利和残疾辅助装备等福利政策。这些福利政策,既能维持竞争力受到损害后残疾退伍军人的生存,也能保证个人和家庭生活质量的不降低,有利于退伍军人身份的顺利转换,以及美国社会的稳定与发展。  相似文献