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Meltem Kilercik Abdurrahman Coskun Mustafa Serteser Deniz Inan Ibrahim Unsal 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):138-145
Background:
The ultra-large von Willebrand factor (vWF) multimers are very active and must be degraded by ADAMTS13 for optimal activity. A severe functional deficiency of ADAMTS13 has been associated with thrombotic thrombocytopenic purpura. The correct interpretation of patient vWF and ADAMTS13 plasma levels requires an understanding of the biological variation associated with these analytes. In the present paper, we aimed to determine the biological variation of ADAMTS13 and vWF in human adults.Materials and methods:
Blood samples were collected weekly from 19 healthy subjects for 5 consecutive weeks. vWF activity and antigenicity were determined using aggregometric and immunoturbidimetric methods. ADAMTS13 antigenicity and activity were determined by ELISA.Results:
The within-subject biological variations for vWF activity and antigenicity were 8.06% and 14.37%, respectively, while the between-subject biological variations were 18.5% and 22.59%, respectively. The index of individuality for vWF activity was 0.44, while vWF antigenicity was 0.64. Similarly, ADAMTS13 activity and antigenicity within-subject biological variations were 12.73% and 9.75%, respectively, while between-subject biological variations were 9.63% and 6.28%, respectively. The ADAMTS13 indexes of individuality were 1.32 and 1.55, respectively.Conclusion:
We report high biological variation and individuality in vWF antigenicity and activity levels. However, ADAMTS13 antigenicity and activity displayed high biological variation, but low individuality. Thus, population-based reference intervals may be useful for monitoring ADAMTS13 antigenicity and activity, but not for vWF, which displays high individuality. These findings should be considered when determining the reference interval and other clinical variables associated with ADAMTS13 and vWF levels. 相似文献2.
David Blamires 《Children‘s Literature in Education》2002,33(4):297-307
Wilhelm Hauff wrote three collections of fairytales that are still widely read in Germany. One of his most popular tales is Dwarf Nose, available in three English translations since 1960. It tells of a boy who is turned into a squirrel for seven years, then regains human form as a dwarf with a long nose before finally achieving normal adult proportions. The story includes details that suggest a sexual interpretation. 相似文献
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威廉二世有建立海军强国的强烈欲望,他在确立了个人统治之后,重组海军部,极力协调"保守派"和"激进派"的海军建设路线之争,加强对海军的宣传,控制舆论导向,争取国会对海军扩张计划的支持。威廉二世的这些举措和努力,为德国海军战略思想转变与海军建设廓清了道路,使德国海军终于进入了大发展时代。 相似文献
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Andreas Zeller 《Informatik - Forschung und Entwicklung》2001,16(2):65-75
Zusammenfassung. Der graphische Debugger DDD ist mit mehr als 250.000 Anwendern ein weitverbreitetes Werkzeug zur Softwarevisualisierung. Neben der für Debuggerüblichen
Funktionalit?t erm?glicht DDD die Visualisierung von Datenstrukturen im laufenden Programm. DDD kann verzeigerte Strukturen (wie Listen oder B?ume) als Graphen darstellen, aber auch numerische
Felder zwei- oder dreidimensional darstellen und im Programmlauf animieren. Dieser Beitrag beschreibt die technischen Grundlagen
der Visualisierung, die verwendeten Plazierungsverfahren und die Animation von Algorithmen.
Eingegangen am 13. Oktober 2000 / Angenommen am 19. Dezember 2000 相似文献
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运用p-adic赋值理论给出了泛可除Bernoulli数B^An／n的系数τu的p—adic赋值的界,从而给出了泛von Staudt定理中部分同余式的简化证明． 相似文献
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Thomas Wala und Nina Miklavc 《Zeitschrift für Hochschulrecht, Hochschulmanagement und Hochschulpolitik: zfhr》2007,6(2):52-60
Die vorliegende Arbeit beschreibt erfolgskritische Faktoren des bei der Erstellung von Diplomarbeiten zwischen Studenten und
Gutachter bestehenden Betreuungsverh?ltnisses und soll praktische Hinweise zu dessen Optimierung liefern. 相似文献
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沈劼 《黄石理工学院学报(人文社科版)》2009,26(5):66-70
本文着重考察了德意志第二帝国外交政策的转变过程,分析了导致其转变发生的国际、国内和个人因素,并进一步探讨了德国外交政策的转变对当时国际政治关系所产生的影响。德国作为一个中欧大国,在转向争取世界霸权的过程中,其外交政策的得失是值得我们深思的。 相似文献
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胡杰 《信阳师范学院学报(哲学社会科学版)》2010,30(2):153-156
威廉二世时代德国的战略困境主要表现为：在地缘政治上,同英、俄两大洲际强国的战略矛盾难以调和;在经济与社会环境上,工业化时代欧洲社会的转型,使极端民族主义情绪甚嚣尘上,矛盾与斗争成为主旋律,加剧了协调的困难;在决策层面上,德国政治精英刻板蛮横、一味强硬的思维模式构成了决策层面的战略困境。这种困境的形成,既有国际环境和德国社会发展的原因,也受到德国决策者个人因素的影响。 相似文献
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Manfred Weiß 《Zeitschrift für Erziehungswissenschaft》2008,11(2):168-182
Keyword: Education Economics and Quality of Schooling. With reference to an earlier keyword article from the same author, this contribution looks at recent developments in education economics. The focus is a critical review of the field‘s contribution to research on the necessary conditions for high quality schooling. Of particular interest at the moment are the institutional framework conditions in a school system, which set incentives for performance. These are judged to be better than resource-based strategies of quality assurance. The empirical basis is provided by estimates of production functions using data from international school performance studies. This article will point out the limited validity of evidence gained through these studies and the – in sum – contradictory empirical findings. For this reason, political recommendations on the basis of this approach should be more reserved. 相似文献