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用阿尔新蓝—番红花红(AB—S)、甲苯胺蓝染色方法,对硫脲致甲状腺功能低下(甲低)大鼠甲状腺内肥大细胞进行染色特性、形态变化及定量研究,发现在甲低时,甲状腺内的肥大细胞数目减少,其形态及染色特性均有明显改变,这些变化表明,肥大细胞对甲低时甲状腺的增生具有明显作用。 相似文献
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S. Jaya Kumari Ganapathy Bantwal Anitha Devanath Vageesh Aiyyar Madhuri Patil 《Indian journal of clinical biochemistry : IJCB》2015,30(2):217-220
Vitamin B12 deficiency has been reported in patients with Autoimmune thyroid disorders. However there is limited data on exact prevalence of low B12 and its correlation with anti-thyroperoxidase antibody (anti-TPO) levels in these patients. The aim of our study was to estimate serum vitamin B12 levels in autoimmune thyroid disorders and to correlate B12 levels with anti-TPO. 350 patients were selected by convenient sampling. Vitamin B12 levels and thyroid parameters were estimated using fully automated chemiluminescence method on Access 2. Results of our study shows that using the manufacturer’s cut-off of 145 pg/mL, the prevalence of low serum vitamin B12 was found to be 45.50 %. Higher prevalence (55 %) was seen based on the published cut-off of 200 pg/mL The study however did not demonstrate any significant correlation between vitamin B12 levels and anti-TPO (r = −0.11 and p value of 0.30).
Electronic supplementary material
The online version of this article (doi:10.1007/s12291-014-0418-4) contains supplementary material, which is available to authorized users. 相似文献4.
甲状腺疾病是外科常见疾病,近年来随着科学技术的进步和社会体检的普及,对甲状腺疾病的诊断方法和早期诊断率不断增加。我国甲状腺疾病患者也呈现逐年增加的趋势,其中,有相当大的一部分患者是需要通过外科手术治疗的。传统甲状腺手术(conventional thyroidectomy,CT)治疗甲状腺疾病已经相对成熟,其安全性、可行性都是毋庸置疑的。CT多会在患者颈部留有明显的长约60mm的手术疤痕。而甲状腺疾病多见于中青年女性,随着社会的不断发展,其中很多患者对于其术后美容效果提出更高要求,所以为了减轻这部分患者术后心理压力,腔镜甲状腺手术(endoscopic thyroidectomy,ETE)应运而生。20世纪末,随着基础与临床研究的突飞猛进,ETE的诞生突破了腔镜技术仅局限于胸腹腔等体内原有的空腔的避障,冲进了有潜在腔隙和无腔隙区域。 相似文献
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歌唱艺术是审美意识的一种特殊表现形式,是最令人感动与陶醉的艺术之一。因此,作为一种美好而有修养的艺术声乐技巧是必须要经过严格的训练过程才可以获得的。对于有甲状腺病变的患者来说,从歌唱的呼吸器官、发声器官、共鸣器官,以及一些其他方面来说,要进行严格的声乐技巧训练有一定的困难。因此,当甲状腺发生病变时,该人群是不适合学习声乐的。 相似文献
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力竭运动对甲状腺激素代谢的影响 总被引：2，自引：0，他引：2
目的为探讨力竭运动对大鼠甲状腺激素代谢的影响及与心肌损伤的关系。方法 :以力竭运动为模型 ,观察了大鼠力竭运动后血清和心肌中四碘甲腺原氨酸 (T4)、三碘甲腺原氨酸 (T3)及心肌中T45′ -脱单碘酶 (T45′-DI)活性的变化。结果 :力竭运动后血清和心肌中T3水平显著升高 (P <0 . 0 1) ,T4水平无显著性改变 ,心肌中T45′ -DI活性显著升高 (P <0 . 0 1)。结论 :力竭运动引起甲状腺激素代谢的改变是造成心肌损伤的原因之一 相似文献
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Manorama Swain Truptirekha Swain Binoy Kumar Mohanty 《Indian journal of clinical biochemistry : IJCB》2005,20(1):9-17
Background: Autoimmune thyroid disease (AITD), a common organ specific autoimmune disorder is seen mostly in women between
30–50 yrs of age. Thyroid autoimmunity can cause several forms of thyroiditis ranging from hypothyroidism (Hashimoto’s thyroiditis)
to hyperthyroidism (Graves’Disease). Prevalence rate of autoimmune mediated hypothyroidism is about 0.8 per 100 and 95% among
them are women. Graves’ disease is about one tenth as common as hypothyroidism and tends to occur more in younger individuals.
Both these disorders share many immunologic features and the disease may progress from one state to other as the autoimmune
process changes. Genetic, environmental and endogenous factors are responsible for initiation of thyroid autoimmunity. At
present the only confirmed genetic factor lies in HLA complex (HLA DR-3) and the T cell regulatory gene (CTLA 4). A number
of environmental factors like viral infection, smoking, stress & iodine intake are associated with the disease progression.
The development of antibodies to thyroid peroxidase (TPO) thyroglobulin (TG) and Thyroid stimulating hormone receptor (TSH
R) is the main hallmark of AITD. Circulating T Lymphocytes are increased in AITD and thyroid gland is infiltrated with CD4+
and CD8+ T Cells. Wide varieties of cytokines are produced by infiltrated immune cells, which mediate cytotoxicity leading
to thyroid cell destruction. Circulating antibodies to TPO and TG are measured by immunofluorescense, hemagglutination, ELISA
& RIA. TSHR antibodies of Graves’ disease can be measured in bioassays or indirectly in assays that detect antibody binding
to the receptor. 相似文献
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潘科 《襄樊职业技术学院学报》2012,11(6):28-29
目的探讨喉罩通气下全麻用于甲状腺手术的可行性及注意事项。资料与方法回顾性分析我院2011年至今共23例甲状腺手术在应用喉罩全麻下的临床资料。结果23例患者均顺利置入喉罩．有2例患者在体位变动时发生漏气,经调整后矫正;手术过程中未发生误吸及胃胀现象;放置喉罩前、后及取出喉罩前、后患者心率、血压无明显变化;23例手术均顺利完成。结论喉罩通气全麻适合甲状腺手术．是甲状腺手术理想的麻醉方法。 相似文献
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Agata M Rudolf Qi Wu Li Li Jun Wang Yi Huang Jacques Togo Christopher Liechti Min Li Chaoqun Niu Yonggang Nie Fuwen Wei John R Speakman 《国家科学评论(英文版)》2022,9(2)
The giant panda (Ailuropoda melanoleuca) is an iconic bear native to China, famous for eating almost exclusively bamboo. This unusual dietary behavior for a carnivore is enabled by several key adaptations including low physical activity, reduced organ sizes and hypothyroidism leading to lowered energy expenditure. These adaptive phenotypes have been hypothesized to arise from a panda-unique single-nucleotide mutation in the dual-oxidase 2 (DUOX2) gene, involved in thyroid hormone synthesis. To test this hypothesis, we created genome-edited mice carrying the same point mutation as the panda and investigated its effect on metabolic phenotype. Homozygous mice were 27% smaller than heterozygous and wild-type ones, had 13% lower body mass-adjusted food intake, 55% decreased physical activity, lower mass of kidneys (11%) and brain (5%), lower serum thyroxine (T4: 36%), decreased absolute (12%) and mass-adjusted (5%) daily energy expenditure, and altered gut microbiota. Supplementation with T4 reversed the effects of the mutation. This work uses a state-of-the-art genome editing approach to demonstrate the link between a single-nucleotide mutation in a key endocrine-related gene and profound adaptive changes in the metabolic phenotype, with great importance in ecology and evolution. 相似文献
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植物幼苗生物场对人体血清甲状腺激素浓度的影响 总被引：1，自引：0，他引：1
应用姜氏生物场导仪，对１０名志愿者用同体对照法观察了植物幼苗生物场对人体血清甲状腺激素浓度的影响。结果是无论场导前低于、等于或高于正常甲状腺激素水平者，场导满疗程后均趋于正常。本研究结果支持植物幼苗生物场对人体具有抗病、保健、抗衰老作用。 相似文献