Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats     

Devendra K. Rai  Prashant Kumar Rai  Aradhna Gupta  Geeta Watal  Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201

Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides such as cartap (50% LD₅₀) and carbofuran (50% LD₅₀) as well as a combination of these two with 25% LD₅₀ of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein, total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses of carbofuran (50% LD₅₀) and cartap (50 % LD₅₀) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD₅₀ of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum lipids in rat.  相似文献