急性白血病相关基因的文本挖掘分析   总被引：2，自引：0，他引：2  

闫雷  崔雷 《情报学报》2008,27(2):169-174

从PubMed检索1966年到2005年9月6日间白血病与基因关系的相关文献3 529篇.经编程处理生成主题词词篇矩阵并进行聚类.通过聚类树图可将所提取的主题词/副主题词分成13类,经对比原始文献进行验证,全部29种基因中只与ALL相关的有3种, 占10.34%;只与AML相关的有8种,占27.59%.特异的可用于鉴别ALL和AML的基因有11种,占37.93%.通过主题词的共现关系进行聚类可以基本实现发现基因与疾病之间的联系,但该方法所获得的相关基因较少,不利于对疾病与基因关系的全面了解.  相似文献   

Off-pump coronary artery bypass grafting versus on-pumpcoronary artery bypass grafting: which is better in patients with chronic obstructive pulmonary disease?     

朱亚彬  许建屏  刘志勇  杨丹宁  李旭东  李鸿雁 《Journal of Zhejiang University. Science. B》2004,(8)

INTRODUCTION Conventional coronary artery bypass graftin(CCABG) with cardiopulmonary bypass (CPB) habeen accepted as an effective and safe treatment fomulti-vessel coronary heat disease. CPB may stilcontribute to the operation field because of threlatively easier technical requirement; but it alscauses a serious systematic inflammatory reactiowhich will lead to dysfunction of important organand higher cost for the patients. Off-pump coronarartery bypass grafting (OPCABG) has r…  相似文献   

Case Report:Lance-Adams syndrome:a report of two cases     

ZHANG Yan-xing    LIU Jian-ren  JIANG biao  LIU Hui-qin  DING Mei-ping  SONG Shui-jiang  ZHANG Bao-rong  ZHANG Hong  XU Bin  CHEN Huai-hong  WANG Zhong-jin  HUANG Jian-zheng 《Journal of Zhejiang University. Science. B》2007,(10)

Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have un-dergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [18F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.  相似文献   

中药复方对抑郁模型小鼠学习记忆能力及脑内SDF-1的影响     

杜娜  陈倩  李洋  肖婧珊  姚梦姣  李亚 《环球赛鸽科技》2015,(3)

目的：探讨中药复方枳菊解郁汤对抑郁模型小鼠空间学习记忆能力的影响及其机制。方法：采用多种因素慢性轻度不可预见性应激方式建立抑郁模型小鼠,分别给予小鼠低、中、高剂量枳菊解郁汤处理。采用Morris水迷宫实验,检测小鼠的空间学习记忆能力的变化;通过免疫组织化学方法检测脑内基质细胞衍生因子(SDF-1)的表达。结果：与对照组相比,模型组小鼠的空间学习记忆能力明显下降(P<0.01),SDF-1在海马CA1,CA3,DG及前脑皮层的表达明显降低(P<0.05);与模型组相比,枳菊解郁汤中剂量组小鼠的空间学习记忆能力明显增高(P<0.05),SDF-1在海马CA1,CA3,DG及前脑皮层的表达明显增加(P<0.05)。结论：枳菊解郁汤的抗抑郁作用可能与SDF-1的表达上调有关。  相似文献   

慢性皮肤溃疡中医特色护理研究概况     

陈俐 《大众科技》2015,17(4)

慢性皮肤溃疡是一种中医外科疑难病,病因复杂,现代医学尚缺乏疗效确切的治疗手段。中医药对该病有许多独特疗法,文章主要从中药膏外敷、中药熏洗与湿敷、按摩、针灸、情志饮食等各方面护理特色进行归纳、阐述,为本病的临床护理提供参考。  相似文献   

赵嘏《读史编年诗》论     

赵望秦 《陕西师范大学学报(哲学社会科学版)》2004,33(6):67-70

赵嘏《读史编年诗》虽于元明之际已佚 ,但有敦煌残卷遗世。考其内容 ,是一部在特定文化背景和创作风气影响下产生的以七言律诗为形式的训蒙作品 ,写法新颖 ,独具特色。由于不切合儿童的学习特性 ,又成为蒙学史上的一部败笔之作  相似文献   

血管内皮生长因子和白细胞介素-12在急性白血病中的表达及临床意义     

高丽君  夏薇  杜冰洋 《中国科学院研究生院学报》2007,24(3):368-371

目的 通过检测急性白血病（AL）患者静脉血清中血管内皮生长因子（VEGF）和 白细胞介素12（IL-12）的含量，探讨VEGF和IL-12在急性白血病中的含量及临床意义。方法 应用定量酶联免疫吸附实验测定10例初诊未治、10例缓解期、5例复发患者和9例正常对照血清中VEGF和IL-12的含量。结果 初诊未治组的VEGF含量（521.06±163.85pg/ml）明显高于缓解组（307.62±55.40pg/ml）及对照组（262.01±141.66pg/ml）（p均<0.05）。对照组的IL-12水平（58.96±38.11pg/ml）与初诊复发组（初诊未治组与复发组的合称32.51±14.58pg/ml）、缓解组（71.67±119.09pg/ml）之间均有显著性差异（p均<0.05）。正常对照组VEGF的含量与IL-12之间存在负相关性。结论 VEGF和IL-12与AL的病情变化有一定的关系。  相似文献   

Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis     

Venkateshwari A  Sri Manjari K  Krishnaveni D  Nallari P  Vidyasagar A  Jyothy A 《Indian journal of clinical biochemistry : IJCB》2011,26(2):136-139

Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase 9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may act as a susceptibility factor for the development of chronic pancreatitis.  相似文献   

Myeloperoxidase in Chronic Kidney Disease     

Madhusudhana Rao A  Anand U  Anand CV 《Indian journal of clinical biochemistry : IJCB》2011,26(1):28-31

Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD). It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant enzyme which could be involved in the increased susceptibility of these patients to CVD. Hence, the levels of plasma MPO was determined in healthy controls as well as in patients with CKD [stratified with the level of their kidney failure as CKD stages II–V (end stage renal disease)]. Plasma MPO was assayed by a spectrophotometric method. Serum urea and creatinine were estimated on a clinical chemistry analyzer using standard laboratory procedures. The mean plasma MPO levels were significantly lower with advancing stages of renal failure (P < 0.001). There was a positive correlation between MPO and GFR (r = +0.89, P < 0.001) and a negative correlation with urea (r = −0.85, P < 0.001) and creatinine (r = −0.82, P < 0.001). While an inverse association was observed between plasma MPO and urea in CKD patients, such an association was not observed in control subjects (P = 0.43). In conclusion, the decline in plasma MPO levels may be due to the inhibitory effect of uraemic toxins on the enzyme.  相似文献   

综合干预老年慢性便秘的疗效观察     

李麒  丘俏芳  张涛  袁伟芳 《宜春学院学报》2014,36(9):63-65

目的：观察综合干预对老年慢性便秘患者的治疗效果,探讨老年慢性便秘的综合干预措施。方法：将门诊92例老年慢性便秘患者随机分为对照组45例和观察组47例。对照组采取常规药物治疗,观察组在对照组治疗措施基础上,实施综合干预。为期6个月。结果：观察组患者治疗显效率、总有效率均明显高于对照组（P〈0.05或P〈0.01）;治疗前两组患者老年慢性便秘保健能力均明显高于对照组（P〈0.01）;治疗后第1周,观察组排便困难程度、大便性状评分均明显低于对照组（P〈0.01）,排便次数明显多于对照组（P〈0.01）。结论：综合干预治疗老年慢性便秘疗效显著,值得推广应用。  相似文献