排序方式： 共有14条查询结果，搜索用时 15 毫秒
1.
Objective： To evaluate the surgical clinical results of hypertrophic obstructive cardiomyopathy. Methods： We retrospectively collected data on 24 patients who underwent surgical management in the past ten years in two hospitals in China and Madras Medical Mission in India. Myomectomy was carried out on all patients. Among them 3 patients underwent mitral valve replacement; 2 patients underwent mitral valve repair （anterior mitral leaflet plication）; 2 patients underwent aortic valve replacement; 1 patient underwent aortic valve repair; 2 patients underwent aortic root replacement; 1 patient underwent Bentall＇s procedure and 1 patient underwent coronary artery bypass grafting because of a breached muscle bridge, Results： One patient died of post-operative heart failure. The mean follow-up time was 4.3 years, There was significant improvement in the symptomatic status. Sixteen patients were asymptomatic with good effort tolerance and only four patients had New York heart association （NYHA） Classes Ⅰ-Ⅱ due to associated valvular lesions, Conclusion： Our experience proved that symptomatic hypertrophic obstructive cardiomyopathy or non-symptomatic hypertrophic obstructive cardiomyopathy with combined heart disease is indication for surgery as surgical intervention could get better clinical results in this kind of patients compared with other non-surgical method because it beneficially reduces the systolic anterior motion （SAM） of the mitral valve leaflet, which could not be avoided by other non-surgical treatment. 相似文献
2.
利用UAS/hand-gal4系统构建果蝇心脏Nmnat基因特异性过表达,研究心脏Nmnat基因过表达联合耐力运动对高脂膳食诱发脂毒性心肌症的影响,并分析其分子机制。方法:雄性w^1118和NmnatUAS系果蝇分别与雌性hand-Gal4杂交,收集F1代心脏Nmnat正常表达(hand>w^1118)和过表达(hand>Nmnat)处女蝇,饲养至15 d后开始进行耐力运动(E)和高脂膳食(HFD),并分为hand>w^1118、hand>w^1118+E、hand>w^1118+HFD、hand>w^1118+HFD+E、hand>Nmnat、hand>Nmnat+E、hand>Nmnat+HFD、hand>Nmnat+HFD+E共8组,每组410只。ELISA检测心脏TAG、NAD+、SIR2蛋白去乙酰化、SOD活力和MDA水平,qRT-PCR检测心脏相关基因mRNA表达,M-mode检测心脏功能情况。结果:hand>w^1118+HFD+E果蝇心脏的Nmnat、dFoxo、bmm表达、NAD+水平、SIR2去乙酰化、SOD活力、缩短分数高于hand>w^1118+HFD(P<0.05或P<0.01),且d FAS和Col4al表达、TAG和MDA水平、心率和纤维性振颤低于hand>w^1118+HFD(P<0.05或P<0.01);hand>Nmnat果蝇心脏各指标与hand>Nmnat+HFD相比较未见显著差异(P>0.05);hand>Nmnat+HFD+E果蝇心脏的Nmnat、dFoxo、bmm表达、心脏NAD+水平、SIR2去乙酰化、SOD活力、心脏缩短分数高于hand>Nmnat+HFD(P<0.05或P<0.01),且dFAS和Col4al表达\TAG和MDA水平、心率和纤维性振颤低于hand>Nmnat+HFD(P<0.05或P<0.01)。结论:心脏Nmnat过表达和耐力运动均能抵抗果蝇高脂膳食诱发的心脏脂质过度堆积、氧化损伤、减弱心脏收缩能力和增加纤维性振颤,其分子机制与心脏Nmnat/NAD+/SIR2/dFoxo通路活性增强有关。心脏Nmnat基因过表达联合耐力运动能更好地降低脂毒性心肌症的发生概率,其机制与二者联合对心脏Nmnat/NAD+/SIR2/dFoxo通路活性上调的叠加作用有关。 相似文献
3.
Serum total cholesterol and triglyceride levels were estimated in 45 dilated cardiomyopathy (DCM) patients and were compared
with 31 healthy controls. The total serum cholesterol (215±50 mg/dl) and serum triglyceride (162±76 mg/dl) levels in DCM patients
did not show any significant changes as compared to normal controls. The cholesterol and triglyceride and the individual lipoprotein
fractions, viz HDL, VLDL, LDL and chylomicrons were analysed in 10 patients. The values did not differ significantly when
compared to those of controls. These findings suggest that serum lipids may not play a role in the antietiopathogenesis of
DCM. 相似文献
4.
Vidya Akhileshwar Samir P. Patel Surendra S. Katyare 《Indian journal of clinical biochemistry : IJCB》2007,22(1):84-90
Studies were carried out to examine and compare the effects of alloxan-diabetes on reactive oxygen species (ROS) related parameters
in the heart from male and female rats. Effects of insulin treatment were also evaluated. The diabetic state severely compromised
the ROS defense mechanism in the cardiac tissue and the effects were more pronounced in the female than in the male rats.
There was several fold increase in the xanthine oxidase (XO) activity in general and the magnitude of increase was higher
in the females; insulin treatment resulted in further increase in the XO activity. The glucose-6-phosphate dehydrogenase (G6PDH)
and catalase activities decreased and the reduced glutathione (GSH) content in mitochondria was completely depleted in diabetic
state with significant decrease in the GSH levels in the post-mitochondrial fraction; the effect was more pronounced in the
females. The superoxide dismutase (SOD) and glutathione peroxidase (GPox) activities increased in the diabetic state to a
greater extent in male rats. Insulin treatment had restorative action only on some parameters. In conclusion, our results
suggest that diabetic state may further compromise the weak ROS defense systems in the heart thus initiating a lesion at the
level of mitochondria which ultimately leads to cardiomyopathy and the effects are especially more pronounced in the females.
Our results also pointed out that insulin treatment was ineffective in restoring ROS related parameters. 相似文献
5.
基于基因芯片技术对心肌钙蛋白(cTnI)基因上的突变进行了分析.针对外显子上的突变特征设计了特异性探针,制备了可以同时检测cTnI基因上第3,5,7,8外显子突变的低密度基因芯片.对每一个外显子,设计了2条5'端标记荧光的寡核苷酸链,一条模拟野生型序列,另一条模拟突变型序列,将二者混合起来模拟杂合子序列.经过实验条件的优化,制作的芯片可以灵敏、特异地检测cTnI基因外显子上的突变.结果表明,该芯片检测突变正配错配区别明显,荧光强度比值符合理论估计(正中碱基错配的信号强度是完全正配信号强度的50%左右).经进一步对芯片优化后,该芯片有望在家族性肥厚型心肌病的研究和诊断中得到应用. 相似文献
6.
为了研究彩色多普勒超声心动图对缺血性心肌病与扩张型心肌病的鉴别诊断价值.对经临床确诊的扩张型心肌病(DCM)85例,缺血性心肌病(ICM)130例的彩色多普勒超声心动图(CDUCG)资料进行对比分析.结果表明:1)两组都有左房室内径增大.DCM组心脏多个房室腔扩大呈球形结构,室壁变薄及弥漫性运动减低,ICM组室壁运动减低多为节段性,常伴有室间隔及左室后壁增厚.2)DCM组左室流出道增宽的病人较ICM组明显多.3)DCM组多瓣膜返流发病率高且程度较重,ICM组多为单瓣膜返流且程度较轻.4)DCM组收缩功能降低明显,舒张功能可正常,二尖瓣E/A>1,ICM组大多数表现为左室舒张功能障碍.可见上述超声心动图特征对ICM和DCM的鉴别诊断有重要价值. 相似文献
7.
Mohammad Qasem Keith George John Somauroo Lynsey Forsythe Benjamin Brown 《Journal of sports sciences》2019,37(3):306-312
Athlete pre-participation screening is focused on detecting pathological conditions like arrhythmogenic right ventricular cardiomyopathy (ARVC). The diagnosis of ARVC is established by applying the revised 2010 ARVC Task Force Criteria (TFC) that assesses RV structure and function. Some athletes may meet structural TFC without having ARVC but we do not know the consequences for RV function. This study compared RV structural and functional indices in male athletes that meet the structural TFC (MTFC) for ARVC and those that do not (NMTFC). We recruited 214 male elite athletes. All participants underwent 2D, Doppler, tissue Doppler and strain (ε) echocardiography with a focused and comprehensive assessment of the right heart. Athletes were grouped on RV structural data: MTFC n = 34; NMTFC n = 180. Functional data were compared between groups. By selection, MTFC had larger absolute and scaled RV outflow tract (RVOT) diameter compared to NMTFC (P ?0.05) but these athletes did not develop a proportional increase in the RV inflow dimensions. There was no difference in global conventional RV systolic function between both groups however, there was significantly lower global RV ε in athletes that MTFC which can be explained, in part, by the RVOT dimension. 相似文献
8.
人参皂苷Rg1对糖尿病大鼠心肌氧化应激及细胞凋亡的影响（英文） 总被引：2，自引：0，他引：2
Hai-tao YU Juan ZHEN Bo PANG Jin-ning GU Sui-sheng WU 《Journal of Zhejiang University. Science. B》2015,16(5):344-354
目的:探讨人参皂苷Rg1对高血糖所致心肌损害的保护作用及其机制。创新点:使用糖尿病大鼠为实验对象,探讨三种浓度的人参皂苷Rg1对糖尿病心肌损伤的保护作用及其机制,检测其是否具有浓度依赖性。方法:将60只Wistar大鼠随机分组,其中空白对照组10只,另50只给予高脂高糖饲养,4周后腹腔注射40 mg/kg链脲佐菌素(STZ)。成功制备糖尿病大鼠模型40只,再随机分为糖尿病模型组,糖尿病大鼠+低剂量人参皂苷Rg1(10 mg/(kg·d)),糖尿病大鼠+中剂量人参皂苷Rg1(15 mg/(kg·d)),糖尿病大鼠+高剂量人参皂苷Rg1(20 mg/(kg·d))。12周后处死大鼠,取血测定空腹血糖、总胆固醇(TC)、甘油三酯(TG)、心肌酶及氧化应激水平,留取心肌组织使用透射电镜观察心肌细胞超微结构改变,应用TUNEL法检测心肌细胞凋亡,免疫组化检测细胞凋亡相关蛋白半胱氨酸天冬氨酸蛋白酶3(CASP3)和Bcl-x L的表达。结论:人参皂苷Rg1对糖尿病大鼠糖脂代谢无明显影响,人参皂苷Rg1可降低糖尿病大鼠血清肌钙蛋白(c Tn I)和肌酸激酶同工酶(CK-MB)水平,改善心肌细胞超微结构,减少心肌细胞凋亡,降低大鼠血清和心肌组织中丙二醛(MDA)含量,提高超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH)水平,降低凋亡蛋白CASP3的表达,同时提高Bcl-x L蛋白表达。总之,人参皂苷Rg1能显著保护糖尿病大鼠心肌损伤,其机制可能与其抗氧化及抗细胞凋亡作用有关。 相似文献
9.
Li-na Han Shuang He Yu-tang Wang Li-ming Yang Si-yu Liu Ting Zhang 《Journal of Zhejiang University. Science. B》2013,14(8):676-687
Monoclonal antibodies have become a part of daily preparation technologies in many laboratories. Attempts have been made to apply monoclonal antibodies to open a new train of thought for clinical treatments of autoimmune diseases, inflammatory diseases, cancer, and other immune-associated diseases. This paper is a prospective review to anticipate that monoclonal antibody application in the treatment of myocarditis, an inflammatory disease of the heart, could be a novel approach in the future. In order to better understand the current state of the art in monoclonal antibody techniques and advance applications in myocarditis, we, through a significant amount of literature research both domestic and abroad, developed a systematic elaboration of monoclonal antibodies, pathogenesis of myocarditis, and application of monoclonal antibodies in myocarditis. This paper presents review of the literature of some therapeutic aspects of monoclonal antibodies in myocarditis and dilated cardiomyopathy to demonstrate the advance of monoclonal antibody application in myocarditis and a strong anticipation that monoclonal antibody application may supply an effective therapeutic approach to relieve the severity of myocarditis in the future. Under conventional therapy, myocarditis is typically associated with congestive heart failure as a progressive outcome, indicating the need for alternative therapeutic strategies to improve long-term results. Reviewing some therapeutic aspects of monoclonal antibodies in myocarditis, we recently found that monoclonal antibodies with high purity and strong specificity can accurately act on target and achieve definite progress in the treatment of viral myocarditis in rat model and may meet the need above. However, several issues remain. The technology on how to make a higher homologous and weak immunogenic humanized or human source antibody and the treatment mechanism of monoclonal antibodies may provide solutions for these open issues. If we are to further stimulate progress in the area of clinical decision support, we must continue to develop and refine our understanding and use of monoclonal antibodies in myocarditis. 相似文献
10.
心肌病起病隐袭，多数情况下发病机理和致病原因不明．病程、预后悬殊，本文对１５例住院心肌病患者进行前瞻性回顾并作初步分析，认为其预后与心力衰竭、心律失常和栓塞症有关． 相似文献