排序方式： 共有33条查询结果，搜索用时 15 毫秒
1.
为了使构造候选标签SNP子集既包含最多SNP位点,又保证包含的冗余信息尽可能少,本文结合单体型数据及标签SNP选择的特点,依据连锁不平衡度量这一重要遗传现象,以多位点连锁不平衡度量值为优化目标,提出了一种改进的蚁群组合优化算法,提高了搜索组合空间的效率。 相似文献
2.
Biswas D Vettriselvi V Choudhury J Jothimalar R 《Indian journal of clinical biochemistry : IJCB》2011,26(2):172-177
Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type
2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T > G of adiponectin gene and
type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with
75 apparently healthy controls. The genotype frequency of SNP45 T > G in exon 2 of adiponectin gene was determined by PCR
based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC↓GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp)
and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T > G and
type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312–10.983). Therefore, SNP45T > G in adiponectin gene may be one of the risk factors for
type 2 diabetes. 相似文献
3.
Upendra Yadav Pradeep Kumar Vandana Rai 《Indian journal of clinical biochemistry : IJCB》2021,36(1):23
Methionine synthase reductase (MTRR) is an important enzyme of the folate/homocysteine pathway. It is responsible for regulation of methionine enzyme by reductive methylation. A common variant A66G is reported in the FMN-binding domain of the MTRR gene, which leads to substitution of isoleucine by methionine (I22M) in MTRR enzyme with reduced activity. Reduced catalytic activity of enzyme leads to high homocysteine concentration in blood and increases risk for numerous diseases. The frequency of A66G polymorphism varies in different ethnic groups. The present study has been designed to evaluate the frequency of MTRR A66G gene polymorphism in the Eastern UP population by PCR–RFLP method. Along with this we also performed a meta-analysis to evaluate the global prevalence of this polymorphism. Databases were screened to identified the eligible studies. The prevalence of the G allele and GG genotype was determined by the use of prevalence proportion with 95% CI. Open meta-analyst software was used for the meta-analysis. Total 1000 blood samples were analyzed, the frequencies of A and G alleles were 0.35 and 0.65 respectively. Meta-analysis results revealed that the prevalence of G allele and GG genotype were 49.4% (95% CI 40.6–58.1, p ≤ 0.001) and 24.3% (95% CI 17.8–30.9, p ≤ 0.001) respectively. In sub-group meta-analysis, the lowest frequency of G allele was found in South America (32.7%; 95% CI 14.1–51.3, p ≤ 0.001), and highest in Asia (56.4%; 95% CI 39.5–73.3, p ≤ 0.001). The results of the meta-analysis showed that the Asian population has the highest frequency of G allele and highest frequency of the GG genotype was found in the European population. 相似文献
4.
介绍了实现运行时的多态性几个重要因素——虚函数、基类和派生类。通过实例阐述了虚函数如何实现运行时的多态性的,用运行结果数据详细分析了运行时的多态性的过程。最后说明了动态绑定实现的原理。 相似文献
5.
范秋生 《黄冈职业技术学院学报》2006,8(4):82-84
本文分析了C++中的两种多态性:编译时的多态性和运行时的多态性,通过函数重载和虚函数对其进行了探讨,指出了虚函数是实现动态联编的关键。 相似文献
6.
Shao-jun ZHU Kui-rong WANG Xiong-xin ZHANG Sheng-mei ZHU 《Journal of Zhejiang University. Science. B》2019,(7):598-604
目的:通过对右美托咪定静脉输注的临床研究,评价中国汉族人群中肾上腺素α2A受体基因多态性与右美托咪定心血管效应的相关性.创新点:探索右美托咪定的心血管系统反应与肾上腺素α2A受体基因多态性的关系,期望为临床个体化应用右美托咪定及其他α2受体激动剂提供重要的依据.方法:本研究取得单位伦理委员会的批准,所有受试者告知受试内容并签署知情同意书.60例美国麻醉医师协会Ⅰ-Ⅱ行择期手术汉族患者根据标准入选本研究.通过静脉输注右美托咪定,记录收缩压、舒张压、心率等心血管效应数据,并用聚合酶链式反应(PCR)法检测ADRA2A基因单核苷酸多态性.结论:中国汉族人群中肾上腺素α2A受体C-1291G基因多态性与应用右美托咪定后心率变化有相关性. 相似文献
7.
INTRODUCTIONCoronaryarterydisease (CAD)continuestobethemajorcauseofmorbidityandmortalityinourcountry .TheactivityofbloodcoagulationfactorshasbeenshowntobeanimportantriskindicatorforCAD .However,circulatinglevelsofcoagulationfactorsmaynotaccuratelyreflectt… 相似文献
8.
Interleukin-6 polymorphisms modify the risk of periodontitis： a systematic review and meta-analysis 总被引：1，自引：0，他引：1
Mei-ying Shao Ping Huang Ran Cheng Tao Hu 《Journal of Zhejiang University. Science. B》2009,10(12):920-927
Objective
To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted. 相似文献9.
目的:探讨基因多态性对速度类项目成绩的影响,以期为寻找适用于我国优秀运动员相关运动基因型提供理论依据,从而使运动选材更趋向科学性和准确性。方法:根据基因多态性所表现的个体差异,通过信息技术方法,对各洲际国家之间在速度类项目中,前八名总数进行比较分析,剖析运动员在世界体坛上创造一个又一个神话的根本原因。结论:基因多态性可以作为运动员选材分子生物学标记。建议:开展我国不同地区人群的基因多态性与运动的关联性研究,对我国寻求优秀运动员具有重要的研究价值。 相似文献
10.
Amrita Chaudhary Pradeep Kumar Vandana Rai 《Indian journal of clinical biochemistry : IJCB》2021,36(3):257
Catechol-O-methyl transferase (COMT) enzyme catalyzes the metabolism of dopamine and other catechols in the brain. Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism as risk factor for alcohol dependence (AD) but the results were inconclusive. The aim of present meta-analysis was to evaluate the association of Val158Met (COMT) polymorphism with AD. Authors performed keyword search of the 4 electronic databases—Pubmed, Google Scholar, Springer Link and Science Direct databases up to December 31, 2019. Total eighteen studies that investigated the association of Val158Met polymorphism with AD were retrieved. The pooled results from the meta-analysis (2278 AD cases and 3717 healthy controls) did not show association with AD using all 5 genetic models (allele contrast model: OR = 1.02, 95% CI = 0.90–1.14, p = 0.03; homozygote model: OR = 1.06, 95% CI = 0.81–1.38, p = 0.69; dominant model: OR = 0.99, 95% CI = 0.85–1.14, p = 0.87; co-dominant model: OR = 0.97, 95% CI = 0.86–1.11, p = 0.71; recessive model: OR = 1.05;95% CI = 0.85–1.29, p = 0.61). Results of subgroup analysis showed that Val158Met is not risk for AD in Asian and Caucasian population. In conclusion, COMT Val158Met is not a risk factor for alcohol dependence. 相似文献