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J Kato Alice Abraham Ruram S Sekharjit Singh S Bilasini Devi Th Ibetombi Devi W Gyaneshwar Singh 《Indian journal of clinical biochemistry : IJCB》2007,22(1):128-130
The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid
peroxidation and antioxidant vitamins-vitamins A, vitamin C and vitamin E in 75 confirmed cases of urolithiasis. Significantly
high level of MDA (p<0.001) with significantly low levels of vitamin E (p<0.001) and vitamin A (p<0.001) with no significant
decrease in vitamin C (p>0.05) were observed in the plasma of urolithiasis cases as compared to normal controls. In conclusion,
it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis. But, the exact
mechanism how this occurs remains to be elucidated. 相似文献
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Vasavidevi V. Bet Kishor H. Deshpande Adinath N. Suryakar Rajesh D. Ankush Raghavendra V. Katkam 《Indian journal of clinical biochemistry : IJCB》2006,21(2):177-180
Crystal aggregation and retention are critical events for the formation of kidney stones. There is a close association between
crystal development and free radical activity in vivo. In the present study 30 subjects presenting with urolithiasis were
included. Serum levels of total lipid peroxides, nitric oxide (as nitrite), α-tocopherol, plasma ascorbic acid (vitamin C)
and erythrocyte superoxide dismutase activity were measured. These findings were compared with 30 age matched control subjects
irrespective of sex. Student's ‘t’ test was applied for statistical analysis. There was a significant increase in lipid peroxides
(p<0.001), where as significant decrease in nitrite (p<0.01) and α-tocopherol (p<0.001) levels were observed. Plasma ascorbate
(p>0.05) and erythrocyte superoxide dismutase activity (p>0.05) was also found to be decreased but the difference was not
statistically significant which suggests that oxidative stress is evident in urolithiasis with depletion in antioxidant status
where as decrease in nitric oxide may be less abetting in disease condition. 相似文献
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Rama D. Mittal Hemant K. Bid Parmeet K. Manchanda Rakesh Kapoor 《Indian journal of clinical biochemistry : IJCB》2008,23(2):106-116
Urolithiasis is a relevant clinical problem with a subsequent burden for health system. The aim of this review is to provide
recent progress made using genetic polymorphisms to define pathophysiology, to identify persons at risk for kidney stone disease
and to predict treatment response. Population case-control studies are useful both as an alternative and an adjunct as compared
to family studies. These involve either whole genome scanning or candidate gene approaches. While whole genome scanning is
likely to be widely used in future, at present, candidate gene studies are more feasible. When performing candidate gene case-control
studies factors such as study design, methods for recruitment of case and controls, selection of candidate genes, functional
significance of polymorphisms chosen for study and statistical analysis require close attention to ensure that only genuine
associations are detected. Some of the significant genes that play role in stone formation include calcitonin receptor gene
(CTR), vitamin D receptor (VDR), Urokinase, Interleukin, (IL-1β, IL-Ra), E-Cadherin, Androgen & oestrogen receptor gene, vascular
endothelial growth factor (VEGF) and Arginine p21. In our case-control study we studied CTR, VDR, Urokinase, IL-1β(−511 and
+3954), IL-Ra from north India and predict that VDR, IL-β (-511) and IL-1Ra gene may be used as a possible genetic marker
for earlier detection in patients who are at risk for calcium oxalate stone disease. Further, linkage disequilibrium and haplotype
structure of a certain candidate gene is important for association analysis. When a certain polymorphic allele has been found
to be associated with disease, it is further explained on basis of LD and haplotype structure by one or more other alleles.
Once it is determined which haplotype carries the risk allele, by means of molecular biological functional analyses, the variants
on that haplotype allele truly causing the effect can be determined. 相似文献
4.
Fluoride content was measured in 100 urinary stones retrieved by open surgery of stone formers admitted at PGIMS Rohtak and
their respective urine and serum and compared with those of healthy individuals. The concentration of fluoride was also measured
in the sources of drinking water of these stone formers. The concentration of fluoride was definitely significantly higher
in serum (p>0.01) and highly significantly higher in urine (p>−0.001) of stone formers compared to those of healthy individuals.
The content of oxalate in serum and 24 h urine of the stone formers was also measured, which was increased significantly (p<0.005
and p<0.001) compared to healthy individuals. The concentration of fluoride was probably significantly higher in drinking
water of these stone formers than the normal ones. There was a positive correlation between the content of fluoride of urinary
stones and urine of stone patients (r=.88); stone and serum (r=.62); drinking water and stone (r=.85) and their urine and
serum (r=.54); urine and drinking water (r=.83) and serum and water (r=.51). These results indicate a definite role of fluoride
in urinary stone formation. 相似文献
5.
Effect of pyridoxine (Vitamin-B6) supplementation on calciuria and oxaluria levels of 20 normal healthy persons and 17 urinary stone patients has been studied.
Mean 24 hr urinary calcium and oxalate levels of controls (healthy persons) and stone patients were estimated in presupplementation
period and at every 20 days interval during supplementation. Stone patients were divided into two groups viz., mild hyperoxaluriacs
and moderate hyperoxaluriacs, based on their pre-supplementation (base line) oxaluria levels. 60 days of pyridoxine supplementation,
at the rate of 10 mg/day, resulted in a significant decrease (p<0.01 for mild hyperoxaluriacs and p<0.001 for moderate hyperoxaluriacs)
in mean 24 hr urinary oxalate levels of urinary stone patients. The corresponding decrement in mean oxaluria level of controls
was, however, only mild. The decrease of mean calciuria level of controls as well as stone patients, upon pyridoxine supplementation,
were also found to be only mild and not significant. Utility of pyridoxine therapy in oxalate urolithiasis has been discussed
in the light of results. 相似文献
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