Serum glycoconjugates and ceruloplasmin in cancer of uterine cervix     

Sharmila Upadhya  Subramanya Upadhya  K. S. Prabhu 《Indian journal of clinical biochemistry : IJCB》2002,17(1):20-24

The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer. Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03). Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia, as serum ceruloplasmin (an acute phase reactant) is also increased in these patients.  相似文献   

Salivary glycoproteins as indicators of oral diseases     

Praveen Kumar Shetty  T. N. Pattabiraman 《Indian journal of clinical biochemistry : IJCB》2004,19(1):97-101

The present study deals with the estimation of total carbohydrate, protein bound carbohydrate, bound fucose and sialic acid along with total protein in disease conditions like gingivitis, periodontitis and their comparison with the normals. The neutral hexose values in gingivitis (8.08±2.20mg/100mg protein) and periodontitis (12.5±2.16mg/ 100mg protein) decreased significantly when expressed per 100 mg protein compared to normals (19.8±1.89mg/100mg protein). This might be because of higher protein concentration in these two clinical conditions. The ethanol insoluble hexose values were significantly reduced in both these conditions compared to controls (3.71±1.64,5.91±1.63,7.65±0.86mg/100mg protein respectively). The ethanol soluble hexose values were also found to be drastically reduced. This decrease in saliva appears to be characteristic feature of oral diseases. In gingivitis and periodontitis fucose level was found to be increased compared to normals when expressed as a function of salivary volume. However in terms of protein concentration the values in gingivitis (2.95±1.59), periodontitis (3.26±0.98) and normals (3.20±0.50mg/100mg) were not different. Sialic acid in ethanol insoluble fraction of salivary samples mg/100mg protein was found to be significantly reduced in both gingivitis (0.78±0.33) and periodontitis (0.95±0.31) compared to controls (1.92±0.33)  相似文献