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D. Puri K. M. Prabhu G. Dev S. Agarwal P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2011,26(4):335-346
To study the mechanism of action of water soluble compound GII purified from fenugreek (Trigonella foenum graecum) seeds which was shown earlier to have antidiabetic effect in the subdiabetic, moderately and severely diabetic rabbits.
In rabbits (1–1.5 kg bw) diabetes was induced by intravenous injection of 80 mg/kg bw of alloxan. They were fed with GII at
a dose of 50 mg/kg bw daily once in the morning for 15 days in the subdiabetic and moderately diabetic and 30 days in the
severely diabetic rabbits. Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol
[(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway)
hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase
and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase
were estimated. Liver and kidney function parameters were also estimated. Treatment with GII for 15 days in the subdiabetic
and moderately diabetic rabbits and for 30 days in the severely diabetic rabbits (i) decreased the elevated lipids TC, TG,
(LDL + VLDL)C and increased the decreased (HDL)C, (ii) decreased the elevated liver and heart total lipids, TC and TG, (iii)
increased the decreased liver and muscle glycogen, (iv) increased the decreased hexokinase, glucokinase, pyruvate kinase,
malic enzyme, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutathione peroxidase, (v) decreased the increased
glucose-6-phosphatase, sorbitol dehydrogenase, aldose reductase. Results thus show that treatment with GII compound purified
from fenugreek seeds for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits corrects
the altered serum lipids, tissue lipids, glycogen, enzymes of glycolysis, gluconeogenesis, glycogen metabolism, polyol pathway
and antioxidant enzymes. Histopathological abnormalities (fatty infiltration and other cellular changes) seen in the pancreas,
liver, heart and kidneys were repaired after treatment with GII. In fact partially damaged pancreas was repaired. Liver and
kidney function test results were normal in the GII treated animals indicating that GII treatment is safe and free from any
side effects. 相似文献
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Roderick F. G. J. King Carlton Cooke Sean Carroll John O'Hara 《Journal of sports sciences》2013,31(12):1361-1363
Abstract The potential for imprecision in the estimation of hydration status from changes in body mass has been outlined previously but the equations derived from these derivations appear inconsistent. Reconciliation of body mass loss in terms of sweat loss and effective body water loss is possible from specific equation sets provided that gains and losses of both body mass and water used in the derivation of sweat loss and to derive effective body water loss are in inclusive equation sets. This is obligatory so that mass and water changes as quantifiable determinants are consistent with both internal processes and external gains and losses. Thus, body mass loss, substrate oxidation, metabolic water, and all the terms used in simultaneous equation sets have to be reconciled not only as identical variables but mathematically balance exactly. The revised equation for effective body water loss given here is different from that originally proposed. Metabolic water is part of body mass loss corrected for substrate oxidation, fluid ingestion, and respiratory water to derive sweat loss and it may not be justified to also include water associated with glycogen as releasable bound water. Accordingly, our calculated effective body water loss is substantially a greater loss than originally supposed but clearly still less than the simple balance between mass loss and fluid ingested. 相似文献
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模拟不同海拔高原训练对大鼠骨骼肌蛋白质与糖原含量的影响 总被引：6，自引：0，他引：6
用低压氧舱模拟海拔２０００米、３０００米高度进行１周耐力训练,观察对骨骼肌细胞蛋白质和肌糖原含量的影响,验证１周时间高原训练的效果,同时观察各高度训练１周后平原效应期２周间的变化。结果表明：高原耐力训练可导致骨骼肌蛋白质分解代谢增强,蛋白质净降解,并有随高度升高而加剧的趋势,同时可提高骨骼肌中肌糖原贮量;不同海拔高度１周耐力训练后的平原效应期间,骨骼肌蛋白质含量第１周即可完全恢复,第２周保持稳定水平,肌糖原含量第１周下降,第２周显著回升。本研究支持高原训练的高度应在２０００～３０００米之间,回平原参赛时间应选择在下高原３天以内或２周以后的观点 相似文献
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余萍 《岳阳职业技术学院学报》2010,25(1):71-72
糖原累积病Ⅰ型为常染色体隐性遗传病,多发生于婴幼儿和青少年。本病系先天性肝、肾等组织中缺乏葡萄糖-6-磷酸酶所致。细胞核内糖原累积、肝脂肪变性明显但无纤维化改变是本型突出的病理变化。本病诊断分型的主要依据是肝穿刺新鲜组织酶活性检测。 相似文献
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高淑杰 《广州体育学院学报》2006,26(2):73-76
研究了健康大学生外固定腿2周使肌肉愈接近废用性萎缩,并在固定期和恢复期10周过程中连续补充肌酸和抗阻训练,测定股外侧肌葡萄糖转运蛋白4(glucose transporter 4,GLUT4)的变化,并且测定了肌糖原、磷酸肌酸(CP)和肌酸(C)浓度。探讨补充肌酸对骨骼肌废用性萎缩后糖代谢调节机制的影响。研究结果显示:补充肌酸和抗阻训练可以提高废用性萎缩肌肉GLUT4蛋白水平,肌肉吸收葡萄糖和肌糖原合成能力增强。肌肉CP、C和C总浓度在恢复期第3周达到高水平。 相似文献
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L-carnitine is popular as a potential ergogenic aid because of its role in the conversion of fat into energy. The present study was undertaken to investigate the effect of short term supplementation of L-carnitine on metabolic markers and physical efficiency tests under short term calorie restriction. Male albino rats were divided into four groups (n = 12 in each)—control, calorie restricted (CR for 5 days, 25 % of basal food intake), L-carnitine supplemented (CAR, given orally for 5 days at a dose of 100 mg/kg), CR with L-carnitine supplementation (CR + CAR). Food intake and body weight of the rats were measured along with biochemical variables like blood glucose, tissue glycogen, plasma and muscle protein and enzymatic activities of CPT-1 (carnitine palmitoyl transferase-1) and AMP kinase. Results demonstrated that L-carnitine caused marked increase in muscle glycogen, plasma protein, CPT-1 activity and swim time of rats (P < 0.05) on short term supplementation. In addition to the substantive effects caused by CR alone, L-carnitine under CR significantly affected muscle glycogen, plasma protein, CPT-1 activity and AMP kinase (P < 0.05). Short term CR along with L-carnitine also resulted in increased swim time of rats than control, CR and L-carnitine treated rats (P < 0.05). The present study was an attempt towards developing an approach for better adherence to dietary restriction regimen, with the use of L-carnitine. 相似文献
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Hui-yu ZHANG Yu-nan ZHAO Zhong-li WANG Yu-fang HUANG 《Journal of Zhejiang University. Science. B》2015,(1):62-69
探讨慢性皮质酮（CORT）注射对脑糖原水平以及小鼠抑郁样行为的影响。 相似文献
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大豆皂甙饮料缓解体力疲劳作用的实验研究 总被引：1，自引：0，他引：1
目的:研究大豆皂甙饮料的缓解体力疲劳作用。方法:采用雄性ICR小鼠,大豆皂甙饮料按33.3ml/kg.bw、66.7ml/kg.bw、100.0ml/kg.bw连续灌胃30d,测定小鼠负重游泳时间、血乳酸、血清尿素氮和肝糖原含量。结果:100.0ml/kg.bw剂量组小鼠负重游泳时间显著长于对照组(P<0.05).66.Tml/kg.bw剂量组游泳后0min血乳酸含量和3个时点血乳酸曲线下面积显著低于对照组(P<0.05、P<0.01)。33.3ml/kg.bw剂量组肝糖原含量显著高于对照组(P相似文献
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