过度训练对大鼠血清心肌酶活性的影响   总被引：6，自引：0，他引：6  

王沛 《西安体育学院学报》2001,18(2):35-37

为了探讨过度训练对机体心脏功能的影响及其机制 ,通过对大鼠进行力竭性运动训练建立大鼠的过度训练模型 ,测定血清中CK、CK -MB、HBDH的活性以及心肌组织中SOD活性和MDA含量。研究结果 :经过 8周的运动训练后 ,1h训练组中血清CK、CK -MB和HBDH活性与对照组相比有上升趋势 ,但无显著性差异 ;而过度训练组血清CK、CK -MB和HBDH活性均显著高于对照组和 1h训练组。与此同时 ,1h训练组心肌组织中SOD活性、MDA含量和SOD/MDA与对照组相比均无显著性差异 ;而过度训练组心肌组织中 ,MDA含量显著高于对照组 ,SOD活性和SOD/MDA均显著低于对照组和 1h训练组。结果表明过度训练对心肌细胞具有一定的损伤作用 ,过度训练使心肌组织中氧自由基的生成显著增加 ,这可能也是血清心肌酶活性升高的机制。训练过程中定期检测血清心肌酶的活性 ,对于了解运动员的机能状态 ,预防过度训练的发生具有非常重要的意义。  相似文献   

Cell therapy in congestive heart failure   总被引：5，自引：0，他引：5  

Tao ZW  Li LG 《Journal of Zhejiang University. Science. B》2007,8(9):647-660

Congestive heart failure （CHF） has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout （necrosis and apoptosis） plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells （CSCs） within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells （BMCs） to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animat CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction.  相似文献   

Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention   总被引：2，自引：0，他引：2  

Zhou BQ  Tahk SJ 《Journal of Zhejiang University. Science. B》2007,8(8):575-579

Objective: The beneficial effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been well established, but there is the problem of no-reflow phenomenon which is an adverse prognostic factor in primary PCI. In the present study the effect of a distal protection device (PercuSurge GuardWire; GW) on epicardial blood flow and myocardial perfusion was evaluated. Methods and Results: Patients with AMI were randomly divided into 2 groups, the GW and the control groups. The GW group included 52 patients with AMI who underwent primary PCI with GW protection and the control group included 60 patients who underwent primary PCI without GW protection. Epicardial blood flow in the infarct-related artery (IRA) and myocardial perfusion were evaluated according to the thrombolysis in myocardial infarction (TIMI) flow grade and the myocardial blush grade (MBG). We found TIMI score of 3 was obtained significantly more frequently in the GW group (96%) than in the control group (80%). The MBG score of 3 was obtained also significantly greater in the GW group (65%) than in the control group (33%). Conclusion: Primary PCI with GW protection can significantly improve epicardial blood flow and myocardial perfusion.  相似文献   

抗阻训练对心梗大鼠心脏和骨骼肌NRG1表征的影响及其性别差异     

王庆安  蔡梦昕  田振军 《北京体育大学学报》2014,37(11):68-72+85

摘要：目的：探讨抗阻训练对心肌梗死(myocardial infarction, MI)大鼠心脏和骨骼肌形态结构及神经调节蛋白1（Neuregulin1, NRG1）表征的影响及其性别差异。方法：3月龄Sprague Dawley大鼠,随机分为雄性假心梗组(MS)、雄性心梗安静组(MMI)、雄性心梗运动组(MMR)、雌性假心梗组(FS),雌性心梗安静组(FMI)和雌性心梗运动组(FMR),每组8只。MMR和FMR组进行为期4wk负荷渐进性递增抗阻训练。血流动力学测定心功能;组织学染色观察并计算形态学变化;检测心脏和骨骼肌中NRG1和ErbB2/4受体的表达变化。结果：MI后大鼠心功能显著降低,心肌组织出现替代性纤维化,腓肠肌质量和细胞横截面积不同程度减小。抗阻训练显著提高了MI大鼠心功能,增加了腓肠肌相对质量和细胞横截面积,同时显著上调雄性MI大鼠心肌和骨骼肌中NRG1蛋白水平及雄性和雌性MI大鼠ErbB2和ErbB4的表达(p<0.05, p<0.01)。结论：抗阻训练促进MI大鼠心功能改善和骨骼肌生长,上调心肌和骨骼肌中NRG1及其受体表达,且不同性别之间存在程度差异性。  相似文献   

运动心脏心肌收缩成分缩短加速度的生理意义     

李昭波 《西安体育学院学报》1994,(3)

本文首次较全面论述了心肌收缩成分缩短加速度这一类精确地、敏感地，在更深层次上反映心肌收缩性能的指标在运动心脏功能研究中的生理意义，详细探讨了心肌收缩成分缩短加速度类指标提出的背景、测量原理，曲线波型特点及参数值．为这类指标在运动性心脏心肌收缩性能的研究中的应用，提供了基础参考资料。  相似文献   

运动性心脏心肌收缩性现代研究     

李昭波 《西安体育学院学报》1994,(1)

运动性心脏心肌收缩性的研究是运动员心脏功能研究的热点之一．本文较祥细论述了经过系统训练的人和动物，在运动负荷状态下、过度运动负荷状态和安静状态下心肌收缩性能的变化特征，生理意义和预后发展．并对其产生的生理机制进行了探讨．为更深入了解运动性心脑心肌收缩性能的变化特征提供了参考资料．  相似文献   

Effect of arogh—A polyherbal formulation on the marker enzymes in isoproterenol induced myocardial injury     

S. Suchalatha  C. S. Shyamala Devi 《Indian journal of clinical biochemistry : IJCB》2004,19(2):184-189

To study the protective role of Arogh on isoproterenol induced myocardial damage in rats. The effect of Arogh pretreatment on isoproterenol induced myocardial damage was assessed by studying the levels of lipid peroxides and changes in the activity of marker enzymes such as creatine kinase, lactate dehydrogenase and transaminases in serum and heart tissue. In isoproterenol administered rats, a significant decrease was observed in the activity of marker enzymes in the heart with a corresponding increase in their levels in serum. Lipid peroxide levels increased significantly in the serum and heart. In rats pretreated with arogh, the level of lipid peroxides and the activity of marker enzymes were maintained at near normal values. Pretreatment with Arogh offered a protective effect against isoproterenol induced myocardial damage in rats as evidenced by LDH isoenzyme patterm and histopathological studies of heart tissue.  相似文献   

运动性心肌肥厚中PKC信号通路研究进展     

柳华  杨翼 《湖北体育科技》2011,30(6):676-680

心肌肥厚是心脏受到刺激后的一种代偿反应。心肌的生理性肥厚可提高心脏机能,但病理性肥厚则会引起心血管疾病心律失常发病和死亡,亦是运动员发生猝死的原因之一。明确运动性心肌肥厚的机制,可为保护运动员心脏提供理论依据。目前为止,形成心肌肥厚的信号通路包括PKC、蛋白激酶B（Akt）、钙调神经磷酸酶（CaM）、丝裂原活化蛋白激酶...  相似文献   

Evaluation of Anti-hypertrophic Potential of Enicostemma littorale Blume on Isoproterenol Induced Cardiac Hypertrophy     

V. A. Doss  Dharaniyambigai Kuberapandian 《Indian journal of clinical biochemistry : IJCB》2021,36(1):33

The main objective of this study is to evaluate the anti-hypertrophic potential of the aqueous extract of Enicostemma littorale (E. littorale) against isoproterenol induced cardiac hypertrophic rat models (male albino Wistar rats) through biochemical investigations. Aqueous extract of E. littorale known for various beneficial properties was administered (100 mg/kg, 12 days, oral) to isoproterenol (ISO) induced cardiac hypertrophic rats (low ISO—60 mg/kg, 12 days and high ISO—100 mg/kg, 12 days, subcutaneous) and were compared with group that was treated with the reference drug, Losartan (10 mg kg, administered for 12 days, oral). The anti-hypertrophic effect of E. littorale was evaluated by analysing the morphometric indices of the heart, ECG tracings, changes in blood biochemical parameters viz., serum glucose, serum total protein, serum albumin, lipid profile, cardiac specific enzymes (SGOT, SGPT and LDH) and histopathological examination of the heart tissue. The results fundamentally revealed that the plant extract efficiently ameliorated cardiac hypertrophy induced by ISO injected in experimental rats. The outcomes of biochemical investigations of this study highlighted the association between the hypertrophic β-adrenergic receptor signalling (β-AR) and the 5′ AMP-activated protein kinase (AMPK)—peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) axis in the metabolism of cardiac fibrosis and hypertrophy. This β-AR/AMPK-PGC1α signalling stem can serve as a key target in ameliorating cardiac hypertrophy through focus on its principal regulators. To add, we also propose that the glycoside, swertiamarin present in this plant with the reported anti-fibrotic potential in liver can be further isolated and evaluated for its anti-hypertrophic potential to treat cardiac hypertrophy.  相似文献   

血清心肌肌钙蛋白T(cTnT)在运动性心肌损伤检出中的应用   总被引：1，自引：1，他引：0  

刘凌  范启国  岳峰 《体育与科学》2005,26(5):64-66,71

由于缺乏特异性强的心肌标记物，对运动训练中造成的心肌损伤难以早期诊断，心肌肌钙蛋白T（cTnT）作为新的心肌标记物，为运动所致的心肌损伤提供了新的监测手段。通过对运动员大量周训练中血清cTnT浓度变化的检测，我们明确检测到运动性心肌损伤的存在，并对该损伤进行评价。方法：选取划艇队员17名，分为一线组和非一线组，观察两组队员在经过大周期训练中的两个最大量周训练中的血清cTnT和CK浓度变化，结合大周期训练中摄氧量变化，对其心脏机能进行评定。结果：在cTnT、CK血清浓度变化上，各组队员血清cTnT含量均属适度增长范围，各组的cTnT、CK两者之间存在相同的变化趋势。一线组队员cTnT、CK血清浓度在第一个大量周升高，第二个大量周下降（P〈0．01）而非一线组队员两周内cTnT和CK血清浓度呈上升趋势（P〈0．01）。在摄氧量多个方面，一线组训练前后有显著性变化（P〈0．05或P〈0．01或P〈0、001），心肺机能得到发展，非一线组队员摄氧量各方面变化不明显。结论：在大运动量训练中存在心肌受损，但该心肌受损是可复的。  相似文献