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Fadhaa A. Ghafil Bassim I. Mohammad Hussain S. Al-Janabi Najah R. Hadi Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81
Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses. 相似文献
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Ai-bin ZHANG Yi-fan PENG Jun-jun JIA Yu NIE Shi-yu ZHANG Hai-yang XIE Lin ZHOU Shu-sen ZHENG 《Journal of Zhejiang University. Science. B》2019,(7):605-612
目的:外泌体及其内容物是各种肝脏疾病的潜在生物标志物。本研究探索外泌体及其内容物在肝移植排斥反应及预后中的作用。创新点:本研究发现外泌体及内含物半乳糖凝集素-9(galectin-9)在肝移植术后排斥及预后预测中发挥重要作用。方法:分别从急性排斥和肝功能稳定患者提取外泌体,进行分离、鉴定并检测其内含蛋白。候选蛋白通过在73个急性排斥病人和63个肝功能稳定病人切除肝的组织芯片中进行验证。最后将蛋白表达量和临床参数纳入Kaplan-Meier生存率和Cox回归分析。结论:外泌体来源的galectin-9可作为预测肝移植术后排斥发生及预后的生物学指标。 相似文献
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目的 :为了解儿童急性呼吸道感染中的流感嗜血杆菌与生物分型及其对抗生素的敏感情况。方法 :对 78例急性呼吸道感染儿童采用常规方法进行了培养 ,药敏试验与生物分型。结果 :共分离出流感嗜血杆菌 33株 ,检出率为 4 2 .3% ,在对所有分离株进行的生物分型结果中 ,共检出 5型 ,其中以Ⅳ ,Ⅵ型居多 ,分别为Ⅳ型 8例 (2 4 .2 % ) Ⅵ型 13例 (39.4 % )。 33株分离出的流感嗜血杆菌中 ,全部菌株对氯霉素 ,氧氟沙星敏感 ,头孢拉定株 2 1(6 3.6 % ) 、头孢唑林 19株 (5 7.6 % )、去甲万古霉素 2 3株 (6 9.7% ) 、苯唑青霉素 31株 (93.4 % ) 、复方磺鞍甲基异唑 11株 (33.3% )、红霉素 4株 (13.2 % )。结论 :儿童急性呼吸道感染中流感嗜血杆菌有较高的检出率 ,以生物Ⅵ型和Ⅳ型居多。流感嗜血杆菌存在着严重的耐药倾向。 相似文献
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Lakshmi Lavanya Reddy Swarup A. V. Shah Alpa J. Dherai Chandrashekhar K. Ponde Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2016,31(1):87-92
Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP. 相似文献
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Cell therapy in congestive heart failure 总被引：5，自引：0，他引：5
Congestive heart failure （CHF） has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout （necrosis and apoptosis） plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells （CSCs） within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells （BMCs） to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animat CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction. 相似文献
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Effect of a distal protection device on epicardial blood flow and myocardial perfusion in primary percutaneous coronary intervention 总被引：2，自引：0，他引：2
Objective: The beneficial effect of percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) has been well established, but there is the problem of no-reflow phenomenon which is an adverse prognostic factor in primary PCI. In the present study the effect of a distal protection device (PercuSurge GuardWire; GW) on epicardial blood flow and myocardial perfusion was evaluated. Methods and Results: Patients with AMI were randomly divided into 2 groups, the GW and the control groups. The GW group included 52 patients with AMI who underwent primary PCI with GW protection and the control group included 60 patients who underwent primary PCI without GW protection. Epicardial blood flow in the infarct-related artery (IRA) and myocardial perfusion were evaluated according to the thrombolysis in myocardial infarction (TIMI) flow grade and the myocardial blush grade (MBG). We found TIMI score of 3 was obtained significantly more frequently in the GW group (96%) than in the control group (80%). The MBG score of 3 was obtained also significantly greater in the GW group (65%) than in the control group (33%). Conclusion: Primary PCI with GW protection can significantly improve epicardial blood flow and myocardial perfusion. 相似文献
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《European Journal of Sport Science》2013,13(3):191-198
Abstract In the present study, we evaluated the duration of slow-wave sleep (Stage 3 and 4) and total delta power (< 3Hz) in all-night non-rapid eye movement (NREM) sleep electroencephalograms (EEGs) of athletes during normobaric hypoxia at simulated altitudes of 1500 m. Seven male athletes slept for two nights in a normoxic condition and one night in an hypoxic condition equivalent to an altitude of 1500 m. Whole-night polysomnographic recordings, thoracic and abdominal motion, nasal and oral airflow, and blood oxygen saturation (SpO2) were recorded. Visual sleep stage scoring and fast Fourier transformation analyses of EEG were performed using 30-s epochs. Mean and minimum SpO2 decreased significantly during sleep in the hypoxic condition. Between groups, changes in heart rate, respiratory disturbance measures including apnoea and hypopnoea, slow-wave sleep and total delta power of the all-night NREM sleep EEG were small and non-significant for the hypoxic condition. However, individual difference in time at an SpO2 below 90% were large in the hypoxic condition, and both slow-wave sleep and total delta power of all-night NREM sleep EEG decreased in three participants who spent a prolonged time below 90% SpO2. The present results suggest that monitoring time below 90% SpO2 is recommended when studying individuals' living-high schedule even under hypoxic conditions equivalent to an altitude of 1500 m. 相似文献