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1.
针刀松解法治疗膝骨关节炎临床对照研究 总被引：3，自引：0，他引：3
目的：通过与电针治疗膝骨关节炎的疗效进行对比，观察针刀对膝骨关节炎患者各项指标的影响以及总体疗效如何。方法：采用随机、对照的方法，试验组24例，采用针刀治疗；对照组24例，采用电针治疗。对比两组临床疗效。结果：（1）经过3周的治疗，电针组和针刀组均取得了一定的近期效果，与治疗前相比各项指标均有显著改善，两组的有效率比较无显著差异。（2）疗效的趋向性与治疗方法有关，针刀组更加趋向于临床治愈（P=0.04）。（3）两组患者治疗前后自身指标分值比较：疼痛、关节僵硬、生理功能、压痛、肿胀、关节活动度均有下降，具有统计学意义；针刀组与电针组治疗后各指标分值比较，疼痛、关节僵硬、生理功能、压痛、肿胀均无统计学意义。针刀组患者治疗后关节活动度显著优于电针组。结论：通过上述研究认为针刀治疗膝骨关节炎近期疗效良好，值得进一步深入研究。 相似文献
2.
目的：探讨运动性的骨性关节炎发病机制及其实验室指标的变化情况。方法：对80例长跑爱好者进行分组，其中影象学或症状提示骨性关节炎的18例，对照62例，检测所有受试者的蛋白多糖含量，并对骨性关节炎患者进行抗环状胍氨酸多肽抗体（CCP）检测。结果：骨性关节炎患者的蛋白糖、IgA、IgG和补体C3明显较对照组显著性差异（P〈0．05），6／18的骨性关节炎患者中可以检测到抗环状胍氨酸多肽抗体。结论：关节软骨中蛋白多糖含量下降是造成关节软骨破坏、形成骨性关节炎的重要因素。 相似文献
3.
Pradeep Sharma Neelima Singh Vinod Singh Sanjeev Singh Harsh vardhan Singh Sameer Gupta 《Indian journal of clinical biochemistry : IJCB》2006,21(1):205-207
Osteoarthritis of knee joints is a disease of old age in both sex. It is very common after the age of 40 years in elderly
females or in postmenopausal phase of females. It is characterized by narrowing of space in joints due to inflammation. The
exact mechanism of inflammation in this disease is not yet clear. Tumor necrosis factor alpha (TNF-α) may involve in onset
of disease. The present study is being carried out in 130 female subject of age group 40–60 years suffering from osteoarthritis
of knee joints and 50 normal healthy control female subjects. A correlation is made between TNF-α and estrogen and found significant
inverse correlation (r<0.001), between TNF-α and estrogen hormone in osteoarthritic female patients as compared to normal
healthy control female group. 相似文献
4.
本文从三个方面综述了我国运动损伤及骨关节病的研究现状及进展。旨在抛砖引玉 ,使广大体育科研工作者对这方面有一总体认识 ,进而从中发掘自己的研究方向。 相似文献
5.
手法配合中药外洗治疗膝关节骨性关节炎的临床疗效观察 总被引：9，自引：0，他引：9
观察通络柔膝手法配合利膝健步汤外洗对于肝肾不足、筋脉瘀滞型膝关节骨性关节炎的疗效并探讨其作用机理。方法：对膝关节骨关节炎患者60例随机分成治疗组和对照组进行治疗，治疗组运用通络柔膝手法配合利膝健步汤外洗综合治疗，对照组采用目前治疗膝关节骨性关节炎常用药物——氨糖美辛治疗。结果表明：两组之间存在显著性差异。讨论与结论：根据两组治疗前后结果的统计分析，对膝关节骨关节炎的病因病机、综合疗法的作用机理进行了探讨，认为膝关节骨关节炎乃本痿标痹之证，肝肾不足为本，瘀滞经脉为标，该综合疗法能有效的治疗膝关节骨关节炎。 相似文献
6.
目的:通过膝关节功能康复保健操功能锻炼对膝部骨性关节炎患者的临床评价,探讨膝关节功能康复保健操的疗效和作用,旨在建立膝骨关节炎功能锻炼方法。方法:采用随机对照的设计方法,将符合纳入标准的60例膝骨关节炎患者随机分成两组。锻炼组30例,对经基础治疗的患者予以康复保健操锻炼治疗;对照组30例,只给予基础治疗。连续两周后,观察比较两组患者康复前、后膝关节症状改善以及功能恢复的情况,并对两组患者进行计分评定比较。结果:两组在改善膝关节活动度、减轻关节疼痛、缓解晨僵、局部压痛等方面进行了比较,差异具有显著性(P<0.05),锻炼组效果明显优于对照组。结论:膝关节功能康复保健操对改善膝部骨性关节炎生活质量有显著的疗效。 相似文献
7.
伴发ATTR型淀粉样沉积的骨关节炎患者的临床和生物学特征分析(英文)简 总被引：1，自引：0，他引：1
Ya-jun GU Peng GE Yun MU Jin-hai LU Fang ZHENG Xu-guo SUN 《Journal of Zhejiang University. Science. B》2014,15(1):92-99
Objective： Our aim was to investigate clinical and laboratory characteristics of osteoarthritic patients who had amyloid deposition in their knee joints. Methods： Synovial membranes were obtained from 36 patients with knee osteoarthritis （OA） who underwent joint replacement surgery. From this sample, the diagnosis of amyloid was deter- mined by Congo red staining, which demonstrated apple-green birefringence under a polarized microscope. All syn- ovial membranes were immunohistochemically characterized for the expressions of amyloid immunoglobulin light chain （AL-K and AL-,k）, serum amyloid-A （SAA）, amyloidogenic transthyretin （ATTR）, and amyloidogenic 152- microglobulin （A152M）. Matrix-assisted laser desorption-ionizaton/time of flight mass spectrometry （MALDI-TOF MS） was used to analyze transthyretin （TTR） isoforms in the serum of each patient. Results： Nine cases （25%） were found to be amyloid-positive. Immunohistochemicaliy, eight cases （88.9%） had ATTR deposition, and one sample （11.1%） was shown to be AL-K-positive. MALDI-TOF MS identified that the TTR in the serum of the patients was unmodified wild-type TTR, TTR-Cys-S-S-Cys, and TTR-Cys-S-S-CysGly. The age at surgery and the disease duration were sig- nificantly higher in the ATTR-positive group than in the ATTR-negative group. Knee score and function score were significantly lower in the ATTR-positive group than in the ATTR-negative group. Conclusions： Amyloid deposition in synovial membranes of OA patients was found to be ATTR and AL-K. TTR in the serum of the patients was unmodified wild-type TTR together with two isoforms. The high age at surgery, long disease duration, and a deteriorated knee function were associated with ATTR amyloid deposition in the osteoarthritic knee joints. 相似文献
8.
M Maneesh H Jayalekshmi T Suma S Chatterjee A Chakrabarti T A Singh 《Indian journal of clinical biochemistry : IJCB》2005,20(1):129-130
Evidence of increased oxidative stress in patients of osteoarthritis in comparison with healthy control subjects was investigated
by measuring the thiobarbituric acid reactive substances (TBARS), vitamin C, reduced glutathione (GSH) and the activities
of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in erythrocytes. It was observed that osteoarthritis
patients were more susceptible to oxidative damage than controls as evident from increased TBARS and decreased ascorbic acid,
GSH, catalase and GPx in erythrocytes. Significant increase in SOD activity found in patients might be an adaptive response.
With the understanding of the role of antioxidants in arthritis, it is becoming increasingly clear that these agents seem
to be beneficial in osteoarthritis. 相似文献
9.
S. Sandya M. A. Achan P. R. Sudhakaran 《Indian journal of clinical biochemistry : IJCB》2009,24(1):42-48
To study the relative contribution of various matrix degrading enzymes in the pathogenesis of arthritis, changes in the levels
of various matrix metalloprtoteinases (MMPs) during the progression of collagen induced arthritis was studied in experimental
animals. Arthritis was induced in male wistar rats by injecting an emulsion containing collagen type II and Freund’s complete
adjuvant. The duration of the experiment was 35 days. Synovial effusate was collected at regular intervals after induction.
At the end of the experiment serum and cartilage were collected and analysed. Synovial fluid of osteoarthritic patients was
also analyzed. Levels of MMP-2, MMP-3, MMP-9 and MT1-MMP were found to be high in synovial effusate and cartilage of experimental
animals. In synovial effusate of arthritic animals the expression of MMP-3 was found to be high during the early stages while
increase in MMP-2 and MMP-9 occurred at later stages. Synovial fluid of osteoarthritic patients also showed elevated levels
of MMP-2, MMP-3 and MMP-9. Our results indicated that sequential action of MMPs such as MMP-3, MMP-2 and MMP-9 can cause degradation
of articular cartilage extracellular matrix. 相似文献
10.
Hai-ning Zhang Jie Zhang Cheng-yu Lv Ping Leng Ying-zhen Wang Xiang-da Wang Chang-yao Wang 《Journal of Zhejiang University. Science. B》2009,10(9):689-695
to the medial compartment degeneration of the knee in active young patients. 相似文献