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1.
孙健 《沈阳体育学院学报》2004,23(3):372-374
观察15名男子古典摔跤运动员进行三周大强度专项训练对迟延性肌肉酸痛(DOMS)炎症反应的影响。第一周每日评定主观体力感觉等级(RPE)和肌肉酸痛程度,并分别在第一周的第一、三、五天和三周的第七天检测血清肌酸激酶(CK)及白细胞介素(IL 1β,6,8)水平。研究发现:第一周RPE从训练开始便出现显著升高,肌肉酸痛程度则第三、四、五天出现显著变化,第七天均恢复。CK、IL-6也均出现显著升高,IL-1β、IL 8则无显著变化。连续三周训练只有IL-6持续显著变化。提示:长时间大强度专项训练没有使DOMS症状加重,炎症反应也没有进一步恶化,机体已经对训练产生适应。 相似文献
2.
Larry A. Tucker 《Journal of sports sciences》2020,38(9):1026-1035
ABSTRACTThe length of telomeres is an objective measure of biologic ageing. This study evaluated the extent minutes of walking per week are associated with leukocyte telomere length (LTL) in a random sample of 5,823 U.S. adults. The investigation was cross-sectional and data were obtained from the National Health and Nutrition Examination Survey (NHANES). LTL was measured by the quantitative polymerase chain reaction method. Walking minutes was calculated from walking frequency and duration measures. Results showed that for each year of chronological age, telomeres were 15.6 base pairs shorter (P < 0.0001). With walking minutes and LTL treated as continuous variables, the relationship was quadratic, not linear (F = 11.2, P = 0.0023). With walking time divided into three categories, adults who performed ≥ 150 minutes of walking per week had longer telomeres than those who did no regular walking, and those who did some, but less than the recommendation (F = 5.0, P = 0.0137). Regular walkers were estimated to have a biologic ageing advantage associated with 6.5–7.6 years less biologic ageing compared to non-walkers, after adjusting for covariates. Additional investigations designed to study causality and the mechanisms associated with the walking and LTL relationship are needed. 相似文献
3.
Michael Sponder Ioana-Alexandra Campean Michael Emich Monika Fritzer-Szekeres Brigitte Litschauer Jutta Bergler-Klein 《Journal of sports sciences》2017,35(21):2129-2134
Cathepsin S (CS) was shown to play a key role in cancer progression, atherosclerosis, heart valve disease, insulin resistance and diabetes mellitus. The present prospective study aimed to investigate the influence of sports on CS, interleukin-6 (Il-6) and high-sensitivity C-reactive protein (hsCRP) levels.Ninety-eight of 109 participants completed the study. Ergometries were performed at baseline and after 8 months to evaluate/quantify the performance gain. Blood samples were taken at baseline and every 2 months. CS was measured by ELISA (enzyme-linked immunosorbent assay). Compared to the control group (mean performance gain ?3.41 ± 4.62%) we observed a significant physical-activity-induced increase of CS levels (3.45–3.73 ng · ml?1; P = 0.027) and a significant decrease of Il-6 (2.43–1.91 pg · ml?1; P = 0.031) and hsCRP-levels (0.11–0.09 mg · dl?1; P = 0.001) in the intervention group (mean performance gain: 12.13 ± 6.32%). Furthermore, the tendency of the progression was significant for CS and Il-6 (P = 0.002/0.033).We could show a significant sports-induced decrease of the classic inflammation parameters hsCRP/Il-6, probably expressing a downregulation of permanently prevalent inflammation processes. Simultaneously CS levels increased significantly. Our results show that increasing CS amounts are not simply to equal with an enhanced inflammation status and might even have beneficial effects on inflammation and angiogenesis. 相似文献
4.
Wendell Arthur Lopes Neiva Leite Larissa Rosa da Silva Diego Trevisan Brunelli Arthur Fernandes Gáspari Rosana Bento Radominski 《Journal of sports sciences》2016,34(20):1902-1912
The objective of the present study was to investigate the effects of combined training without caloric restriction on inflammatory markers in overweight girls. Thirty-three girls (13–17 years) were assigned into overweight training (n = 17) or overweight control (n = 16) groups. Additionally, a normal-weight group (n = 15) was used as control for the baseline values. The combined training programme consisted of six resistance exercises (three sets of 6–10 repetitions at 60–70% 1 RM) followed by 30 min of aerobic exercise (walking/running) at 50–80% VO2peak, performed in the same 60 min session, 3 days/weeks, for 12 weeks. Body composition, dietary intake, aerobic fitness (VO2peak), muscular strength (1 RM), glycaemia, insulinemia, lipid profile and inflammatory markers (C-reactive protein, interleukin-6, tumour necrosis factor-alpha, interleukin-10, leptin, resistin and adiponectin) were measured before and after intervention. There was a significant decrease in body fat (P < 0.01) and increase in fat-free mass (P < 0.01), VO2peak (P < 0.01), 1 RM for leg press (P < 0.01) and bench press (P < 0.01) in the overweight training group. Concomitantly, this group presented significant decreases in serum concentrations of C-reactive protein (P < 0.05) and leptin (P < 0.05), as well as in insulin resistance (P < 0.05) after the experimental period. In conclusion, 12 weeks of combined training without caloric restriction reduced inflammatory markers associated with obesity in overweight girls. 相似文献
5.
Paul S. R. Goods Brian Dawson Grant J. Landers Christopher J. Gore Kevin Croft Peter Peeling 《European Journal of Sport Science》2016,16(8):1047-1054
This investigation examined the oxidative stress (F2-Isoprostane; F2-IsoP) and inflammatory (interleukin-6; IL-6) responses to repeat-sprint training in hypoxia (RSH). Ten trained male team sport athletes performed 3(sets)*9(repetitions)*5?s cycling sprints in simulated altitude (3000?m) and sea-level conditions. Mean and peak sprint power output (MPO and PPO) were recorded, and blood samples were collected pre-exercise, and again at 8 and 60?min post-exercise. Both MPO and PPO were significantly reduced in hypoxia (compared to sea-level) in the second (MPO: 855?±?89 vs. 739?±?95?W, p?=?.006; PPO: 1024?±?114 vs. 895?±?112?W, p?=?.010) and third (MPO: 819?±?105 vs. 686?±?83?W, p?=?.008; PPO: 985?±?125 vs. 834?±?99?W, p?=?.008) sets, respectively. IL-6 was significantly increased from pre- to 1?h post-exercise in both hypoxia (0.7?±?0.2 vs. 2.4?±?1.4?pg/mL, p?=?.004) and sea-level conditions (0.7?±?0.2 vs. 1.6?±?0.3?pg/mL, p?d?=?0.80) suggesting higher IL-6 levels of post-hypoxia. F2-IsoP was significantly lower 1?h post-exercise in both the hypoxic (p?=?.005) and sea-level (p?=?.002) conditions, with no differences between trials. While hypoxia can impact on exercise intensity and may result in greater post-exercise inflammation, it appears to have little effect on oxidative stress. These results indicate that team sport organisations with ready access to hypoxic training facilities could confidently administer RSH without significantly increasing the post-exercise inflammatory or oxidative stress response. 相似文献
6.
摘要：目的：探讨补充亮氨酸对无训练史被试进行抗阻运动所致骨骼肌损伤的影响。方法：16名青年男性大学生据体重随机分为补充亮氨酸组与安慰剂对照组，亮氨酸和安慰剂组被试从测试日深蹲抗阻运动前3周直至运动后4 d分别以每千克体重150 mg剂量摄入150 mL亮氨酸或糊精溶液。测试日各组被试以50% 1RM负荷完成5组深蹲运动，每组20次，组间间歇2 min。深蹲运动前于肘正中静脉采集血样，测量大腿围、纵跳高度、膝关节活动幅度与肌肉酸痛程度，并于运动后即刻、24 h、48 h、72 h和96 h重复测试。ELISA法检测血清CK-MM、Mb与血浆IL-6，胶乳增强免疫比浊法检测血清CRP。结果：与安慰剂组被试相比，补充亮氨酸显著降低了亮氨酸组被试运动后延迟性肌肉酸痛水平、大腿中段周长及血清CK-MM、Mb、CRP与血浆IL-6含量，而深蹲1-RM值、纵跳高度及膝关节ROM组间差异则并无统计学意义。结论：1）每千克体重150 mg剂量亮氨酸能够削弱抗阻运动所导致的骨骼肌损伤与疼痛，该效应可能与对炎症反应的抑制有关，且推测亮氨酸对骨骼肌蛋白质代谢平衡的调节作用在其中亦有贡献；2）该剂量亮氨酸不能明显促进工作肌机能恢复。 相似文献
7.
目的:通过中小强度有氧运动和辛伐他汀药物干预,探讨AS血管炎性损伤的修复及机制。方法:应用ApoE基因敲除和高脂高胆固醇饲料诱发小鼠AS,分为动脉硬化组、运动组、用药组;ELISA测定血清炎性因子及激素水平;免疫组化法阳性标记TLR4、NF-κb、EGF、TGF-β;RT-PCR测定CRP、MCP-1 mRNA表达。结果:12周动脉硬化组ApoE基因敲除小鼠血管可见明显斑块组织;用药组内皮表层细胞肿胀呈泡沫样,运动组则未见以上组织改变;运动和用药组小鼠血清IL-6、TNF-a含量和血管组织TLR4、NF-κb、CRP、MCP-1表达均降低(P<0.05),而血清IL-10、ET1、AngⅡ和内皮细胞EGF、TGF-βmRNA表达均升高(P<0.05)。结论:有氧运动有效防治AS小鼠血管炎性损伤,其可能机制是介导了Toll样受体通路并恢复血管激素分泌与促进内皮细胞再生。 相似文献
8.
Margetic S 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):49-62
Inflammation and haemostasis are interrelated pathophysiologic processes that considerably affect each other. In this bidirectional relationship, inflammation leads to activation of the haemostatic system that in turn also considerably influences inflammatory activity. Such, the haemostatic system acts in concert with the inflammatory cascade creating an inflammation-haemostasis cycle in which each activated process promotes the other and the two systems function in a positive feedback loop. The extensive crosstalk between immune and haemostatic systems occurs at level of all components of the haemostatic system including vascular endothelial cells, platelets, plasma coagulation cascade, physiologic anticoagulants and fibrinolytic activity. During inflammatory response, inflammatory mediators, in particular proinflammatory cytokines, play a central role in the effects on haemostatic system by triggering its disturbance in a number of mechanisms including endothelial cell dysfunction, increased platelet reactivity, activation of the plasma coagulation cascade, impaired function of physiologic anticoagulants and suppressed fibrinolytic activity. The two examples of pathophysiologic processes in which the tight interdependent relationship between inflammation and haemostasis considerably contribute to the pathogenesis and/or progression of disease are systemic inflammatory response to infection or sepsis and acute arterial thrombosis as a consequence of ruptured atherosclerotic plaque. Close links between inflammation and haemostasis help explain the prothrombotic tendency in these two clinical conditions in which inflammation shifts the haemostatic activity towards procoagulant state by the ability of proinflammatory mediators to activate coagulation system and to inhibit anticoagulant and fibrinolytic activities. This review summarizes the current knowledge of the complex interactions in the bidirectional relationship between inflammation and haemostasis. 相似文献
9.
Luiz Rodrigo Augustemak de Lima Isabela de Carlos Back Everson Araújo Nunes Diego Augusto Santos Silva Edio Luiz Petroski 《Journal of sports sciences》2019,37(1):50-58
This study aimed to investigate if moderate to vigorous physical activity (MVPA) and aerobic fitness are associated with cardiovascular risk factors in HIV+ children and adolescents. Sixty-five children and adolescents (8 to 15 years) provided minutes of MVPA measured by accelerometers and peak oxygen uptake (peak VO2) by breath-by-breath respiratory exchange. Cardiovascular risk factors were characterized by body fat, blood pressure, total cholesterol, HDL-c, LDL-c, triglycerides, glucose, insulin, C-reactive protein (CRP), interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and carotid intima-media thickness. Results indicated that higher MVPA was associated with lower values of total (β = ?3.566) and trunk body fat (β = ?3.495), total cholesterol (β = ?0.112) and LDL-c (β = ?0.830). Likewise, higher peak VO2 was associated with lower total (β = ?0.629) and trunk body fat values (β = ?0.592) and levels of CRP (β = ?0.059). The physically active participants had lower total cholesterol (?24.4 mg.dL?1) and LDL-c (?20.1 mg.dL?1) compared to participants judged to be insufficiently active. Moreover, participants with satisfactory peak VO? showed lower total (?4.1%) and trunk (?4.3%) body fat, CRP (?2.3 mg.L?1), IL-6 (?2.4 pg.mL?1) and TNF-α (?1.0 pg.mL?1) compared to low peak VO2 peers. High levels of MVPA and aerobic fitness may prevent developing of cardiovascular risk factors in children and adolescents HIV+. 相似文献
10.
《European Journal of Sport Science》2013,13(6):611-619
AbstractThis study investigated in older adults whether whole-body vibration (WBV) training results in significant increases of physical fitness measures without alterations in markers of inflammation. Sixteen volunteers completed a WBV programme 3 d.wk?1 during 9 weeks. The programme consisted of lower and upper-body unloaded static and dynamic exercises. Training improved significantly several tests which evaluate physical fitness, such as 30-s chair stand, arm curl or chair sit and reach test. There was a significant increase in maximal voluntary isometric contraction (MVIC) between pre- and post-training conditions. Muscle power values, reached at 20, 40 and 60% MVIC, were also significantly greater after training. However, mRNA or protein levels for C-reactive protein, interleukin-6, interleukin-1β, tumour necrosis factor-α and interleukin-10 did not significantly differ from basal values. Our data confirm the usefulness of WBV training for counteracting the loss of muscle strength associated with sarcopenia in older adults and show that WBV training could be a safe training method which induces no inflammatory effects. 相似文献