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Zhao Q Liu ZD Xue Y Wang JF Li H Tang QJ Wang YM Dong P Xue CH 《Journal of Zhejiang University. Science. B》2011,12(7):534-544
Ds-echinoside A (DSEA), a non-sulfated triterpene glycoside, was isolated from the sea cucumber Pearsonothuria graeffei. In vitro and in vivo investigations were conducted on the effects of DSEA on tumor cell adhesion, migration, invasion, and
angiogenesis. In this study, we found that DSEA inhibited the proliferation of human hepatocellular liver carcinoma cells
Hep G2, with a half-maximal inhibitory concentration (IC50) of 2.65 μmol/L, and suppressed Hep G2 cell adhesion, migration, and invasion in a dose-dependent manner. DSEA also reduced
tube formation of human endothelial cells ECV-304 on matrigel in vitro and attenuated neovascularization in the chick embryo
chorioallantoic membrane (CAM) assay in vivo. Immunocytochemical analysis revealed that DSEA significantly decreased the expression
of matrix metalloproteinase-9 (MMP-9), which plays an important role in the degradation of basement membrane in tumor metastasis
and angiogenesis. DSEA also increased the protein expression level of tissue inhibitor of metalloproteinase-1 (TIMP-1), an
important regulator of MMP-9 activation. From the results of Western blotting, the expressions of nuclear factor-kappa B (NF-κB)
and vascular endothelial growth factor (VEGF) were found to be remarkably reduced by DSEA. These findings suggest that DSEA
exhibits a significant antimetastatic activity through the specific inhibition of NF-κB-dependent MMP-9 and VEGF expressions. 相似文献
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本文描述了核电站建造阶段的安全文化建设和动态危险源识别与控制。危险源识别和控制是一项事前控制,准确及时地对危险源进行识别和有效的控制,采取＂六结合＂的安全管理措施对减少安全事故的发生和提升安全管理绩效有着重要的意义。 相似文献
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本文的主题是世界核电发展形势与核安全要求的提高,在简要回顾世界核电发展历史的基础上,介绍了我国正在积极推进的第三代核电批量建设和自主创新,同时强调认真吸取福岛核电站经验教训,坚持核安全第一。 相似文献
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对于奇异原子可近似视为Rydberg原子,并考虑Rydberg电子与原子实间的相互作用,由此方法计算核极化用以修正C.J.Batty光学模型势下的∑-208PB及∑-184W能级跃迁,其结果比用经典的方法计算出来的结果要精确得多,为超子原子的深入分析提供了理论上的依据. 相似文献
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目的:探讨常压低氧(13.6%氧含量)运动对大鼠心肌核转录因子NF-κB、Cyt c和自噬相关基因Beclin1的影响,为运动与低氧适应机制的研究和高原训练方案的制定提供理论依据。方法:采用酶联免疫吸附技术(ELISA)分别测大鼠心肌NF-κB、Cyt c和Beclin1的含量。结果:通过运动训练、低氧适应或者是低氧运动适应,都能使NF-κB和Beclin1不同程度升高,其中以HC和HiLo较为显著,Cyt c变化不明显,提示运动训练、低氧适应或者低氧运动适应都能诱导自噬的发生。结论:自噬相关基因Beclin1在低氧训练中产生的低氧适应机制可能是低氧刺激后细胞内产生ROS,ROS激活了NF-κB信号通路,使得Beclinl与NF-κB活性增高;通过长期的运动与低氧适应,可能ROS降低有效抑制NF-κB信号通路,使Beclinl和NF-κB产生了适应性变化,Cyt c从线粒体释放较少,提示细胞凋亡率减少,从而保护心肌细胞的作用。 相似文献
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This study investigated the alleviating effects of hydrogen sulfide (H2S), derived from sodium hydrosulfide (NaHS), on inflammation induced by dextran sulfate sodium (DSS) in both in vivo and in vitro models. We found that NaHS injection markedly decreased rectal bleeding, diarrhea, and histological injury in DSS-challenged mice. NaHS (20 µmol/L) reversed DSS-induced inhibition in cell viability in Caco-2 cells and alleviated pro-inflammation cytokine expression in vivo and in vitro, indicating an anti-inflammatory function for H2S. It was also found that H2S may regulate cytokine expression by inhibiting the nuclear factor-κB (NF-κB) signaling pathway. In conclusion, our results demonstrated that H2S alleviated DSS-induced inflammation in vivo and in vitro and that the signal mechanism might be associated with the NF-κB signaling pathway. 相似文献
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介绍了核子秤在特殊情况下的一种使用方法，对计算负荷的公式进行了推导，对该方法造成的误差及使用效果进行了分析。 相似文献
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朝核危机是20世纪90年代以来国际关系研究中的重要问题之一。朝核问题不仅使核不扩散机制面临挑战,而且使得东北亚的安全问题更加复杂,这进一步证明国际关系理论与国际关系的现实之间虽有密切的关系,但是二者也有相当的不一致性,朝核问题也再次显示出国际关系理论与现实的差距。因此,国际关系理论要适应不断发展的现实,为解决现实问题的解决提供可行的理论依据。 相似文献