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急性白血病相关基因的文本挖掘分析 总被引：2，自引：0，他引：2
从PubMed检索1966年到2005年9月6日间白血病与基因关系的相关文献3 529篇.经编程处理生成主题词词篇矩阵并进行聚类.通过聚类树图可将所提取的主题词/副主题词分成13类,经对比原始文献进行验证,全部29种基因中只与ALL相关的有3种, 占10.34%;只与AML相关的有8种,占27.59%.特异的可用于鉴别ALL和AML的基因有11种,占37.93%.通过主题词的共现关系进行聚类可以基本实现发现基因与疾病之间的联系,但该方法所获得的相关基因较少,不利于对疾病与基因关系的全面了解. 相似文献
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目的 通过检测急性白血病（AL）患者静脉血清中血管内皮生长因子（VEGF）和 白细胞介素12（IL-12）的含量，探讨VEGF和IL-12在急性白血病中的含量及临床意义。方法 应用定量酶联免疫吸附实验测定10例初诊未治、10例缓解期、5例复发患者和9例正常对照血清中VEGF和IL-12的含量。结果 初诊未治组的VEGF含量（521.06±163.85pg/ml）明显高于缓解组（307.62±55.40pg/ml）及对照组（262.01±141.66pg/ml）（p均<0.05）。对照组的IL-12水平（58.96±38.11pg/ml）与初诊复发组（初诊未治组与复发组的合称32.51±14.58pg/ml）、缓解组（71.67±119.09pg/ml）之间均有显著性差异（p均<0.05）。正常对照组VEGF的含量与IL-12之间存在负相关性。结论 VEGF和IL-12与AL的病情变化有一定的关系。 相似文献
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Yixin Hu Aili Chen Xinchang Zheng Jun Lu Hailong He Jin Yang Ya Zhang Pinpin Sui Jingyi Yang Fuhong He Yi Wang Peifang Xiao Xin Liu Yinmei Zhou Deqing Pei Cheng Cheng Raul C Ribeiro Shaoyan Hu Qian-fei Wang 《国家科学评论(英文版)》2019,6(3):469
Standard chemotherapy regimens for remission induction of pediatric acute myeloid leukemia (AML) are associated with significant morbidity and mortality. We performed a cohort study to determine the impact of reducing the intensity of remission induction chemotherapy on the outcomes of selected children with AML treated with a low-dose induction regimen plus granulocyte colony stimulating factor (G-CSF) (low-dose chemotherapy (LDC)/G-CSF). Complete response (CR) after two induction courses was attained in 87.0% (40/46) of patients receiving LDC/G-CSF. Post-remission therapy was offered to all patients, and included standard consolidation and/or stem cell transplantation. During the study period, an additional 94 consecutive children with AML treated with standard chemotherapy (SDC) for induction (80/94 (85.1%) of the patients attained CR after induction II, P = 0.953) and post-remission. In this non-randomized study, there were no significant differences in 4-year event-free (67.4 vs. 70.7%; P = 0.99) and overall (70.3 vs. 74.6%, P = 0.69) survival in the LDC/G-CSF and SDC cohorts, respectively. After the first course of induction, recovery of white blood cell (WBC) and platelet counts were significantly faster in patients receiving LDC/G-CSF than in those receiving SDC (11.5 vs. 18.5 d for WBCs (P < 0.001); 15.5 vs. 22.0 d for platelets (P < 0.001)). To examine the quality of molecular response, targeted deep sequencing was performed. Of 137 mutations detected at diagnosis in 20 children who attained hematological CR after two courses of LDC/G-CSF (n = 9) or SDC (n = 11), all of the mutations were below the reference value (variant allelic frequency <2.5%) after two courses, irrespective of the treatment group. In conclusion, children with AML receiving LDC/G-CSF appear to have similar outcomes and mutation clearance levels, but significantly lower toxicity than those receiving SDC. Thus, LDC/G-CSF should be further evaluated as an effective alternative to remission induction in pediatric AML. 相似文献
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《Journal of Zhejiang University. Science. B》2009,10(11)
We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for cluster of differentiation 19 (CDI9), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone marrow showed 47,XX,+21 [2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AM L with trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the sole acquired karyotypic abnormality was discussed. 相似文献
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Hua-feng Wang Yi-zhi Cheng Huan-ping Wang Zhi-mei Chen Ji-yu Lou Jie Jin 《Journal of Zhejiang University. Science. B》2009,10(11):833-838
We report that a 63-year-old Chinese female had acute myeloblastic leukemia (AML) in which trisomy 21 (+21) was found as the
sole acquired karyotypic abnormality. The blasts were positive for myeloperoxidase, and the immunophenotype was positive for
cluster of differentiation 19 (CD19), CD33, CD34, and human leukocyte antigens (HLA)-DR. The chromosomal analysis of bone
marrow showed 47,XX,+21[2]/46,XX[18]. Fluorescent in situ hybridization (FISH) showed that three copies of AML1 were situated
in separate chromosomes, and that t(8;21) was negative. The patient did not have any features of Down syndrome. A diagnosis
of CD19-positive AML-M5 was established with trisomy 21 as a sole acquired karyotypic abnormality. The patient did not respond
well to chemotherapy and died three months after the diagnosis. This is the first reported case of CD19-positive AML with
trisomy 21 as the sole cytogenetic abnormality. The possible prognostic significance of the finding in AML with +21 as the
sole acquired karyotypic abnormality was discussed. 相似文献
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针对筛选特定癌症亚型的特异表达基因,提出了一种新颖的癌症基因芯片的后综分析方法——运用并改进秩打分算法(RS),对有序基因列表的统计均值取秩并打分.该算法结合常用的“一对多”(OVA)比对方法或“一对一”(OVO)比对方法,在跨平台检测某些白血病亚型特异基因时显得极为有效.6个公开的白血病数据的统计结果显示白血病亚型间的分子生物信号差异强于芯片系统间的差异.此外,一组儿童白血病亚型(BCR-ABL)的标志基因能够准确预测成人白血病中的该亚型.结果有助于从白血病或其他有着充分研究背景的癌症芯片表达数据中,发现、确认和治疗其亚型. 相似文献
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INTRODUCTION Telomeres are distinctive DNA-protein struc-tures that cap the ends of linear chromosomes.It is very important to keep the chromosomes stabilization.Telomerase activity is closely linked to attainment of cellular immortality,a step in carcinogenesis,while lack of such activity contributes to cellular senes-cence.Telomerase is activated in more than85%ofmalignant tumors(Hiayma et al.,1997).Human te-lomeric repeat binding factor1(TRF1)is a telomere associated with proteins a… 相似文献
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目的 通过检测急性白血病（AL）患者静脉血清中血管内皮生长因子（VEGF）和 白细胞介素12（IL-12）的含量,探讨VEGF和IL-12在急性白血病中的含量及临床意义。方法 应用定量酶联免疫吸附实验测定10例初诊未治、10例缓解期、5例复发患者和9例正常对照血清中VEGF和IL-12的含量。结果 初诊未治组的VEGF含量（521.06±163.85pg/ml）明显高于缓解组（307.62±55.40pg/ml）及对照组（262.01±141.66pg/ml）（p均<0.05）。对照组的IL-12水平（58.96±38.11pg/ml）与初诊复发组（初诊未治组与复发组的合称32.51±14.58pg/ml）、缓解组（71.67±119.09pg/ml）之间均有显著性差异（p均<0.05）。正常对照组VEGF的含量与IL-12之间存在负相关性。结论 VEGF和IL-12与AL的病情变化有一定的关系。 相似文献