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D. Puri K. M. Prabhu G. Dev S. Agarwal P. S. Murthy 《Indian journal of clinical biochemistry : IJCB》2011,26(4):335-346
To study the mechanism of action of water soluble compound GII purified from fenugreek (Trigonella foenum graecum) seeds which was shown earlier to have antidiabetic effect in the subdiabetic, moderately and severely diabetic rabbits.
In rabbits (1–1.5 kg bw) diabetes was induced by intravenous injection of 80 mg/kg bw of alloxan. They were fed with GII at
a dose of 50 mg/kg bw daily once in the morning for 15 days in the subdiabetic and moderately diabetic and 30 days in the
severely diabetic rabbits. Serum total cholesterol (TC), triglycerides (TG), LDL + VLDL cholesterol [(LDL + VLDL)C], HDL cholesterol
[(HDL)C], total tissue lipids, glycogen and enzymes of carbohydrate metabolism (glycolysis, gluconeogenesis, polyol pathway)
hexokinase, glucokinase, pyruvate kinase, malic enzyme, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, aldose reductase
and sorbitol dehydrogenase and antioxidant enzymes glutathione peroxidase, glutathione reductase and superoxide dismutase
were estimated. Liver and kidney function parameters were also estimated. Treatment with GII for 15 days in the subdiabetic
and moderately diabetic rabbits and for 30 days in the severely diabetic rabbits (i) decreased the elevated lipids TC, TG,
(LDL + VLDL)C and increased the decreased (HDL)C, (ii) decreased the elevated liver and heart total lipids, TC and TG, (iii)
increased the decreased liver and muscle glycogen, (iv) increased the decreased hexokinase, glucokinase, pyruvate kinase,
malic enzyme, glucose-6-phosphate dehydrogenase, superoxide dismutase, glutathione peroxidase, (v) decreased the increased
glucose-6-phosphatase, sorbitol dehydrogenase, aldose reductase. Results thus show that treatment with GII compound purified
from fenugreek seeds for 15 days in the subdiabetic and moderately diabetic and 30 days in the severely diabetic rabbits corrects
the altered serum lipids, tissue lipids, glycogen, enzymes of glycolysis, gluconeogenesis, glycogen metabolism, polyol pathway
and antioxidant enzymes. Histopathological abnormalities (fatty infiltration and other cellular changes) seen in the pancreas,
liver, heart and kidneys were repaired after treatment with GII. In fact partially damaged pancreas was repaired. Liver and
kidney function test results were normal in the GII treated animals indicating that GII treatment is safe and free from any
side effects. 相似文献
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R. Kapoor D. B. Gundpatil B. L. Somani T. K. Saha S. Bandyopadhyay P. Misra 《Indian journal of clinical biochemistry : IJCB》2014,29(2):213-220
Cancer cells generally exhibit increased glycolysis for ATP generation (the Warburg effect). Compounds that inhibit glycolysis have potential applications in cancer treatment. dl-glyceraldehyde (DLG) and 2-Deoxyglucose (2-DG) have been proven effective in the inhibition of glucose metabolism. Ehrlich ascites carcinoma (EAC) cells were injected intraperitoneally (i.p) in 10–12 weeks old Swiss albino mice, weighing between 20 and 30 g. The anticancer activity of DLG and 2-DG were determined by tumor volume, tumor weight, viable and nonviable tumor cell count, average survival time, percentage increase in life span and tumor inhibition ratio. The blood samples were obtained for biochemical analysis after 9 days of treatment to study the effect on liver, kidney and haematological parameters. Histopathological examination of liver and kidney was also performed. One-way ANOVA test and Dunnett’s test were used for comparisons of parameters in study groups. Both DLG and 2-DG individually decreased the tumor weight, tumor volume, viable tumor cell count and significantly increased the life span of treated mice, however the combination was found to be better. The biochemical parameters of liver and kidney functions and haematological parameters were restored close to control group as compared with the EAC bearing mice. Histopathological examination of liver and kidney in EAC control group showed large areas of necrosis, congestion and mononuclear cell infiltration but such changes were not observed in liver and kidney sections observed after i.p injection of DLG and 2-DG for 9 days. Improvement was much better in the group where combination of these two drugs were used. 相似文献
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HIF-1低氧诱导哺乳动物细胞产生适应的关键因子。HIF-1是一种DNA结合蛋白，可以诱导包括糖酵解代谢酶在内的多种基因表达的增加，产生对低氧环境的适应。糖酵解代谢酶的活性在低氧诱导下增加，细胞无氧代谢能力加强。低氧训练的生物学基础在于低氧诱导的细胞适应，因此我们预测大强度的低氧训练(低住高练)可以提高机体的无氧代谢能力。 相似文献
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我国女子水球运动项目起步晚,发展快。缺乏成熟的水球训练理论和女子水球训练实践经验的总结,对水球项目的训练规律的认识还停留在＂边学边干边发展＂的阶段,其训练的基础理论的研究也较为少见。本文根据我国女子水球运动的现状及运动员的身体状态和竞技能力,通过在对四川、宁夏女子水球运动员训练的调研,结合成都体育学院女子水球项目组已建立的糖酵解供能条件下大鼠游泳运动模型,探讨女子水球运动项目的糖酵解供能特征,不同运动负荷对运动员的疲劳和恢复规律,为女子水球项目提供糖酵解供能模型指导下的运动训练的应用情况。 相似文献
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现代800m训练的特点与构思 总被引：1，自引：0，他引：1
黄希斌 《南京体育学院学报(社会科学版)》2001,15(3):85-87
从800m跑的供能特点及发展趋势分析讨论,认为确立以“速度为中心“的训练思路和建立“多课次“的训练结构以及重视机体耐受乳酸能力的力量训练,是当今800m跑训练的主题和有效方法. 相似文献
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Computed results from a mathematical model of the bioenergetics of sprinting, which incorporates a threeequation representation of anaerobic metabolism, were compared with measured distance–time data for female athletes from the finals of the 100-m event at the World Championships of 1987. The computed results closely model the performance of the competitors over the course of the entire race. The three main contributions to anaerobic metabolism were investigated and comparisons were made between male and female sprinters. Whereas the time constants for adenosine triphosphate (ATP) and phosphocreatine utilization for the two sexes were found to be similar, for oxygen-independent glycolysis the time constants of the female athletes were found to be higher. The maximum powers generated by female athletes during ATP conversion and glycolysis were only slightly lower than the figures found for male athletes, but the value for phosphocreatine utilization was substantially lower. The lower value for phosphocreatine utilization might explain the more pronounced fall-off in running speed over the latter stages of a race that female athletes experience in comparison with men. Although anaerobic sources dominate energy provision for both male and female sprinters, the calculations show that the latter make greater use of aerobic energy supplies. 相似文献
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