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Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats 总被引：1，自引：0，他引：1
Binsack R Zheng ML Zhang ZS Yang L Zhu YP 《Journal of Zhejiang University. Science. B》2006,7(11):892-898
Objective： Some animal models apply morphine in the drinking water to generate addiction, but related reports are not free of conflicting results. Accordingly, this study aimed to figure out if chronic consumption of morphine in the drinking water can induce morphine addiction in Wistar rats. Methods： For 3 weeks, the animals received a daily morphine dose of 35 mg/kg by offering a calculated volume of sugar water （5% sucrose） with morphine （0. l mg/ml） to each rat; animals receiving just sugar water served as controls. Immediately after the treatment phase, the tail immersion test was used to check for morphine tolerance, and all animals were then kept on tap water for one week （withdrawal phase）. Afterwards, all rats were allowed to choose their drinking source by offering two bottles, containing sugar water without and with morphine, simultaneously for two days （preference phase）. Results： While the chronic consumption of morphine led to a reduction in body weight and to morphine tolerance, the morphine-treated Wistar rats did not show any preference for the opiate-containing sugar water. Conclusion： Body weight loss and tolerance do not reveal a condition of drug craving, and current animal models should be re-evaluated regarding their potential to establish morphine addicted animals. 相似文献
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目的研究不同年龄自发性高血压大鼠血管平滑肌Ca2+/CaM-PP活性变化.方法应用酶活性测定方法,对12周、16周SHR大鼠和Wistar大鼠的A、MA、CA血管平滑肌Ca2+/CaM-PP进行活性比较.结果Wistar大鼠随年龄增长,Ca2+/CaM-PP活性呈上升趋势,而SHR鼠其阻力血管该酶活性降低,但随年龄变化不明显.结论①自发性高血压使阻力血管平滑肌Ca2+/CaM-PP下降,但12周与16周间无显著差异.②不同种鼠血管平滑肌该酶活性变化不同. 相似文献
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目的 :了解不同水平的蛋白质日粮对实验大鼠生长发育、繁殖性能的影响。方法 :用三种不同蛋白质水平的日粮饲喂实验大鼠 ,观察其生长发育、繁殖性能并测量相关数据。结果 :饲喂高蛋白配方大鼠其体重、平均日增重及料重比等指标极显著 (P <0 .0 1 )或显著 (P <0 .0 5)高于低蛋白配方组和中等水平蛋白配方组。结论 :实验大鼠在生长发育高峰期可喂以高蛋白日粮 ,之后喂以中等水平蛋白质日粮 ,既可保证动物质量 ,亦可获得较好的经济效益 相似文献
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通过观察αB-晶状体蛋白在骨骼肌细胞的变化,了解骨骼肌细胞抵抗运动损伤的机制。方法:成年雄性Wistar大鼠24只,随机分为安静对照组,运动后即刻组,运动后24 h组,每组8只,运动组进行一次性大强度离心运动;取腓肠肌制作冰冻切片,采用免疫荧光组织化学法观察αB-晶状体蛋白在骨骼肌细胞的分布特征。结果:安静状态αB-晶状体蛋白在细胞浆有一定水平的表达,主要分布于胞浆及膜下。离心运动后即刻αB-晶状体蛋白表达增加并且发生移位变化,主要存在于Z盘及细胞膜附近,24 h后αB-晶状体蛋白在细胞膜和Z盘仍有大量分布。结论:离心运动后αB-晶状体蛋白从肌细胞胞浆移位于细胞膜和Z盘,其在骨骼肌可能具有防止Z盘和肌细胞膜骨架蛋白损伤或辅助骨架蛋白修复的作用。 相似文献
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Devendra K. Rai Prashant Kumar Rai Aradhna Gupta Geeta Watal Bechan Sharma 《Indian journal of clinical biochemistry : IJCB》2009,24(2):198-201
Wistar rats of 6–8 weeks in age weighing between 120–150 g were exposed to the fixed doses of each of the carbamate pesticides
such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein,
total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses
of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease
in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats
exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum
lipids in rat. 相似文献
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目的探讨丹参注射液抗肝纤维化作用机理.方法取40只成年wistar大鼠,利用猪血清腹腔注射法,连续6周,复制免疫性肝纤维化模型.治疗组采用大、小剂量丹参液肌肉注射,其剂量分别为0.3ml/kg和0.15ml/kg,每日一次,连续4周.取肝脏切片,HE和Mollory染色,光镜下观察.检测血清SOD活性、MDA含量和肝功能.结果大剂量治疗组肝细胞空泡减少,胶原纤维大部分消失,SOD活性增高,MDA含量降低,与模型组比较有显著性差异(P＜0.05).结论大剂量肌注丹参液,具有治疗肝纤维化的功能. 相似文献
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