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| 运动性心肌重塑的钙振荡动力学与钙信号编码-解码模式 | |
| 引用本文： | 漆正堂,丁树哲,贺杰.运动性心肌重塑的钙振荡动力学与钙信号编码-解码模式[J].广州体育学院学报,2007,27(6):95-99. |
| 作者姓名： | 漆正堂 丁树哲 贺杰 |
| 作者单位： | 1. 华东师范大学体育与健康学院,上海,200241;衡阳师范学院体育系,湖南,衡阳,421008 2. 华东师范大学体育与健康学院,上海,200241 3. 衡阳师范学院体育系,湖南,衡阳,421008 |
| 基金项目： | 衡阳师范学院青年骨干教师培养基金(200607) |
| 摘 要： | 三磷酸肌醇(IP3)浓度的连续变化和线粒体活性调制出频率各异的钙振荡,以波的形式在胞质空间传播,然后被钙振荡频率敏感性分子接收,转化为对酶活性的调节,最终完成对物质代谢和基因表达的调控。运动性心脏重塑过程中的钙振荡频率可能比病理性心脏高。探索心肌细胞钙信号的分子解码器将是我们今后研究运动性心肌重塑可以努力的一个方向。 |
| 关 键 词： | 钙振荡 频率 IP3 线粒体 分子解码器 心肌肥厚 |
| 文章编号： | 1007-323X(2007)06-0095-05 |
| 修稿时间： | 2007年9月14日 |
Dynamics of Calcium Oscillations and Coding-decoding Mode of Calcium Signal in Exercise-induced Cardiac Restructure |
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| QI Zheng-tang,DING Shu-zhe,HE Jie.Dynamics of Calcium Oscillations and Coding-decoding Mode of Calcium Signal in Exercise-induced Cardiac Restructure[J].Journal of Guangzhou Physical Education Institute,2007,27(6):95-99. | |
| Authors: | QI Zheng-tang DING Shu-zhe HE Jie |
| Abstract: | Consecutive changes in intracellular IP3 concentration and mitochondrial activity modulated multiple frequencies of calcium oscillations,which spread as a form of wave in cytosol space and accepted by frequency-sensitive molecules.Calcium signal was transformed into regulations on enzyme activity,which ultimately regulated metabolism and gene expression.Maybe the frequency of calcium oscillation in exercise-induced cardiac restructure was much higher than that in pathological cardiac hypertrophy.Molecular decoder of calcium signals in cardiac myocyte will be one of the fuhure research topics on the exercise-induced cardiac restructure. |
| Keywords: | calcium oscillations frequency IP3 mitochondrial molecular decoder cardiac hypertroph |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |