| 缺氧缺血对心肌细胞的影响及药物保护作用综述 |
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| 引用本文： | 李岩,苏全生.缺氧缺血对心肌细胞的影响及药物保护作用综述[J].成都体育学院学报,2002,28(4):79-82. |
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| 作者姓名： | 李岩 苏全生 |
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| 作者单位： | 1. 烟台师范学院,山东,烟台
2. 成都体育学院,四川,成都,610041 |
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| 摘 要： | 对由于缺氧缺血及恢复期血液再灌注时引起心肌损害的可能机制分析、论证，认为缺氧缺血引起H^ ／Na^ 交换、H^ ／Ca^2 交换和Na^ ／Ca^2 交换活跃，以及自由基对生物膜的攻击作用导致细胞内Ca^2 代谢异常是心肌损害的主要原因。通过补充抗氧化剂、锌、镁等物质可有效地防止和减弱对心肌的伤害作用。
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| 关 键 词： | 心肌 缺氧缺血 再灌注损伤 抗氧化剂 |
| 文章编号： | 1001-9154(2002)04-0079-04 |
| 修稿时间： | 2002年4月25日 |
Effect of Anoxia on Myocardium and Protective of Medicine |
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| Li Yan,Shu Quansheng.Effect of Anoxia on Myocardium and Protective of Medicine[J].Journal of Chengdu Physical Education Institute,2002,28(4):79-82. |
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| Authors: | Li Yan Shu Quansheng |
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| Institution: | Yantai Teacher's College Yantai |
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| Abstract: | From the analysis of possible injury mechanism of cardiac myocyte which is caused by ischemia-reperfusion in restoration period or ischemia and anoxia, the main rreaon of injury in cardiac myocyte is metabolism disorder, that metabolism disorder led by actoveH+/Na+exchange, H+/Ca2+exchange because of ischemia and hypoxia of led by free radical assaulting to biomembrane. On the basis of this analysis, we suggest that filling up anti-oxidant, zinc, magnesium, and other materials may be prevent cardiac myocyte from injured and weaken the injury of cardiac myocyte. |
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| Keywords: | cardiac myocyte ischemia and hypoxia ischemia-reperfusion injury anti-oxidant |
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