| 有氧运动对大鼠动脉粥样硬化发生发展中血浆CO和cGMP的影响 |
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| 引用本文： | 李俊平.有氧运动对大鼠动脉粥样硬化发生发展中血浆CO和cGMP的影响[J].北京体育大学学报,2008,31(11). |
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| 作者姓名： | 李俊平 |
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| 作者单位： | 北京体育大学 |
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| 摘 要： | 目的:探讨有氧运动预防动脉粥样硬化发生发展过程中,血浆一氧化碳(CO)的变化及CO发挥作用的可能机制。方法:高脂膳食建立大鼠动脉粥样硬化模型过程中,分别给大鼠以每天60 min和120 min的游泳训练,8周后检测血浆CO和环磷酸鸟苷(cGMP)含量。结果:在大鼠动脉粥样硬化发生发展中,动脉粥样硬化组血浆CO和cGMP含量较对照组明显升高(P<0.05),60 min和120 min的游泳训练组血浆CO和cGMP含量较动脉粥样硬化组明显降低(P<0.05),游泳训练两组之间组血浆CO和cGMP含量无显著性差异(P>0.05)。血浆CO的变化与cGMP的变化成正相关(相关系数r=0.78)。结论:动脉粥样硬化发生发展过程中血浆CO和cGMP含量升高,有氧运动可使升高的血浆CO和cGMP含量降低,CO-cGMP途径可能是CO发挥效应的机制之一。
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| 关 键 词： | 动脉粥样硬化 一氧化碳 环磷酸鸟苷 血浆 有氧运动 |
The Effect of Aerobic Exercise on CO and cGMP in Rat's Plasma during the Progression of Atherosclerosis |
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| LI Jun-ping.The Effect of Aerobic Exercise on CO and cGMP in Rat's Plasma during the Progression of Atherosclerosis[J].Journal of Beijing Sport University,2008,31(11). |
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| Authors: | LI Jun-ping |
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| Abstract: | Objective: To investigate the effects of aerobic exercise on CO and cGMP in plasma in the progression of atherosclerosis(AS),and to find the possible mechanisms of preventing and ameliorating AS by aerobic exercise.Methods: The model of AS of rats induces by atherogenic diet,and the rats are given different aerobic exercise(60 minutes per day and 120 minutes per day).After 8 weeks, CO and cGMP content in plasma is measured.Results: CO and cGMP content in plasma in the AS group is increased significantly(P<0.05).Compared with AS group,CO and cGMP content in plasma is decreased significantly(P<0.05) in both 60 minutes group and 120 minutes group.CO and cGMP content in plasma has no difference between 60 minutes group and 120 minutes group(P>0.05).The changes of CO are correlated with the changes of cGMP.Conclusions: CO and cGMP content in plasma increase during the progression of AS,aerobic exercise may reduce CO and cGMP content,CO-cGMP might be one of the mechanisms of preventing and ameliorating AS by aerobic exercise. |
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| Keywords: | atherosclerosis Carbon monoxide cGMP plasma aerobic exercise |
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