| 耐力运动对高脂膳食诱导的脂肪肝小鼠UCP2与Mn-SOD表达及与脂肪肝关系的研究 |
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| 引用本文： | 马国栋,高颀.耐力运动对高脂膳食诱导的脂肪肝小鼠UCP2与Mn-SOD表达及与脂肪肝关系的研究[J].北京体育大学学报,2007,30(12):1645-1648. |
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| 作者姓名： | 马国栋 高颀 |
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| 作者单位： | 1. 山东理工大学体育学院,山东,淄博,255049
2. 北京体育大学,北京,100084 |
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| 基金项目： | 山东理工大学博士启动基金 |
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| 摘 要： | 目的:研究耐力运动对高脂膳食诱导的C57BL/6J脂肪肝小鼠肝脏UCP2及Mn-SOD表达与脂肪肝的关系.方法:以高脂膳食诱导的脂肪肝小鼠为模型,分析耐力运动20周后肝脏UCP2及Mn-SOD表达变化与肝脏脂肪变的关系.结果:肝脏UCP2与Mn-SOD在高脂膳食组(HS组)均显著升高;恢复正常膳食结合耐力运动20周组(RE组),Mn-SOD表达进一步升高,而UCP2表达显著降低.HS组形成明显的脂肪肝,恢复正常膳食加20周不运动组与恢复正常膳食结合20周耐力运动组脂肪肝得到明显改善,但RE组改善更为明显.结论:耐力运动可能以上调Mn-SOD表达而下调UCP2表达,达到既清除活性氧又减少肝脏线粒体ATP合成降低目的,从而保护肝脏免受过多活性氧和ATP耗尽的损伤.
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| 关 键 词： | 脂肪肝 解偶联蛋白2 耐力运动 高脂膳食 耐力运动 高脂膳食 膳食诱导 脂肪肝 小鼠肝脏 表达变化 关系 研究 Mice Fatty Liver High Expression Relationship Endurance Exercise 损伤 清除活性氧 保护肝脏 合成 肝脏线粒体 改善 |
| 文章编号： | 1007-3612(2007)12-1645-04 |
| 修稿时间： | 2006年11月2日 |
The Research of Endurance Exercise on Relationship between UCP2 and Mn-SOD Expression and Fatty Liver in High Fat Diet-Induced Fatty Liver Mice |
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| MA Guo-dong,GAO Qi.The Research of Endurance Exercise on Relationship between UCP2 and Mn-SOD Expression and Fatty Liver in High Fat Diet-Induced Fatty Liver Mice[J].Journal of Beijing Sport University,2007,30(12):1645-1648. |
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| Authors: | MA Guo-dong GAO Qi |
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| Abstract: | Objective: To investigate the effects of endurance exercise on relationship between UCP2 and Mn-SOD expression and fatty liver in high fat diet-induced nonalcoholic fatty liver C57BL/6J mice. Methods: It analyzed the relationship between fatty liver and UCP2 and Mn-SOD expression in diet-induced nonalcoholic fatty liver in C57BL/6J mice after 20 weeks' endurance exercise. Results: The levels of UCP2 and Mn-SOD mRNA in liver increased significantly in HS group. Mn-SOD expression increases while UCP2 expression decreases after 20 weeks' endurance exercise and changing into low fat diet in RE group. HS group appeared obvious fatty liver. The pathological situations were improved in RS and RE groups, but melioration was more significantly in RE group. Conclusion: It is suggested that endurance exercise could up-regulate Mn-SOD expression and down-regulate UCP2 expression. This will not only extinguishe more reactive oxygen species but also decrease ATP synthesis in mitochodria, therefore protects liver cells from reactive oxygen species attacked and ATP depletion. |
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| Keywords: | Fatty Liver Uncoupling Protein 2 Endurance Exercise High Fat Diet |
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