| 骨骼肌抗氧化作用的信号转导机制 |
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| 引用本文： | 赵永军,卢健.骨骼肌抗氧化作用的信号转导机制[J].吉林体育学院学报,2010,26(5):89-91. |
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| 作者姓名： | 赵永军 卢健 |
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| 作者单位： | 华东师范大学体育与健康学院,上海200241 |
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| 摘 要： | 现已证明骨骼肌收缩诱导产生的活性氧（ROS）可造成骨骼肌氧化应激水平升高,同时肌肉的抗氧化防御系统的应答性也升高。而NFκB和MAPK是两条主要的氧化应激敏感性信号转导通路,可激活许多酶和蛋白质的基因表达,而这些酶和蛋白质在维持细胞内氧化还原稳态中发挥重要作用。综述讨论上述两条信号转导通路及其适应的生物学差异。
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| 关 键 词： | 抗氧化 促分裂原活化蛋白激酶 核转录因子κB 活性氧 信号传导 |
Antioxidant Signaling in Skeletal Muscle |
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| Zhao Yongjun,Lu Jian.Antioxidant Signaling in Skeletal Muscle[J].Journal of Jilin Institute of Physical Education,2010,26(5):89-91. |
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| Authors: | Zhao Yongjun Lu Jian |
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| Institution: | (College of Sports and Health East China Normal University,Shanghai,200241,China) |
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| Abstract: | It has been known that the contraction of Skeletal muscle can induce the generation of ROS,which can lead to the rising of oxidative stress levels,and the antioxidant defence system activated as a response at the same time.NFκB and MAPK pathways are the two main ROS-sensitivity signalling pathways,which can activate the gene expression of many enzymes and proteins,such as CAT,SOD,GPX and so on.And just these enzymes and proteins play an important role in the balance of cell REDOX steady-state.The two NFκB and MAPK signal pathways were reviewed in this paper and to discuss the biological differences of their adaption to exercise. |
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| Keywords: | antioxidant MAPK NFκB ROS signalling pathway |
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