| 有氧运动对apoE基因缺陷小鼠主动脉脂质斑块面积及血清炎症相关细胞因子水平的影响 |
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| 引用本文： | 孙焱,郝选明,耿青青,金焕,张艳艳,任琦.有氧运动对apoE基因缺陷小鼠主动脉脂质斑块面积及血清炎症相关细胞因子水平的影响[J].北京体育大学学报,2012,35(4):53-58. |
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| 作者姓名： | 孙焱 郝选明 耿青青 金焕 张艳艳 任琦 |
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| 作者单位： | 华东交通大学体育学院;华南师范大学体育科学学院 |
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| 基金项目： | 江西省教育厅青年科学基金“有氧运动与动脉粥样硬化—运动的抗炎症作用研究”(项目编号:GJJ10136) |
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| 摘 要： | 目的:以apoE基因缺陷小鼠建立动脉粥样硬化模型,研究有氧运动对动脉硬化脂质斑块面积和血清相关细胞因子水平的影响。方法:apoE基因缺陷小鼠随机分为安静对照组和运动组(游泳运动,90 min/次,6次/周,周末休息,共持续10周),10周后测定和比较两组小鼠的血脂水平、主动脉血管脂质斑块面积以及血清脂联素(adiponectin)、白介素6(IL-6)和肿瘤坏死因子α(TNF-α)的水平。结果:结果表明,与对照组相比,1)有氧运动组小鼠主动脉的脂质斑块面积明显缩小(P0.05),血脂状况显著改善。2)10周有氧运动可以显著下调apoE小鼠的TNF-α(P0.01)和IL-6(P0.01)水平,同时显著上调adiponectin(P0.01)的水平。结论:1)10周有氧运动能显著抑制apoE基因缺陷小鼠动脉粥样硬化的发展,并改善动脉粥样硬化小鼠的血脂水平。2)10周有氧运动可以显著提高apoE基因缺陷小鼠血清中抗炎因子的水平,同时显著降低促炎因子的水平,两者综合作用的结果,可有效改善apoE基因缺陷小鼠系统的炎症状态。
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| 关 键 词： | apoE基因缺陷小鼠 有氧运动 动脉粥样硬化 细胞因子 |
| 收稿时间： | 2011/6/17 0:00:00 |
The Effect of Aerobic Exercise on Atheromatous Plaques Area and inflammatory-ralated Serum Cytokines of ApoE-Deficient Mice |
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| SUN Yan,HAO Xuan-ming,GENG Qing-qing,JIN Huan,ZHANG Yan-yan and REN Qi.The Effect of Aerobic Exercise on Atheromatous Plaques Area and inflammatory-ralated Serum Cytokines of ApoE-Deficient Mice[J].Journal of Beijing Sport University,2012,35(4):53-58. |
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| Authors: | SUN Yan HAO Xuan-ming GENG Qing-qing JIN Huan ZHANG Yan-yan and REN Qi |
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| Institution: | 1.P.E.Dept.,East China Jiaotong University,Nanchang 330013,Jiangxi China;2.Dept.,of Sports Science,South China Normal University,Guangzhou 510006,Guangdong China) |
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| Abstract: | Objective: ApoE-deficient mice was used as AS model to approach the effect and mechanism of aerobic exercise on formation of atherosclerotic lesions and the effect of serum inflammatory-related cytokines.Method: ApoE-deficient mice were randomly divided into control group(CG) and exercise group(EG,swimming,90min/d,6d/w,10 wks),the lesion area and serum lipid and serum inflammatory-related cytokines were tested after 10 weeks.Result: 1) Compared with CG,the lesion area in the aorta of EG was significantly less than that of the CG(P<0.05).And the serum lipid was improved significantly.2) Compared with CG,the serum levels of TNF-α and IL-6 were significantly down-regulated in the EG(P<0.01),and the adiponectin level was up-regulated significantly(P<0.01).Conclusion:1) The results suggested that aerobic exercise significantly decreased the development of atherosclerotic plaque in apoE-deficient mice and simultaneously improved the fat metabolism.2) Aerobic exercise significantly decreased the pro-inflammatory cytokine and increased the anti-inflammatory cytokine simultaneously in apoE-deficient mice.The systemic inflammation can be effectively improved from aerobic exercise. |
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| Keywords: | apoE-deficient mice aerobic exercise atherosclerosis cytokine |
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