| 四周高住低训对大鼠骨骼肌p70~(S6K)的影响 |
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| 引用本文： | 李晓红,赵华,曾凡星.四周高住低训对大鼠骨骼肌p70~(S6K)的影响[J].北京体育大学学报,2010(3). |
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| 作者姓名： | 李晓红 赵华 曾凡星 |
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| 作者单位： | 北京体育大学; |
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| 基金项目： | 国家自然科学基金项目(批准号30671013)。北京体育大学2009届本科毕业论文 |
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| 摘 要： | 目的:探讨低氧运动对大鼠骨骼肌蛋白量及p70S6K的影响。方法:SD大鼠分为四组:常氧安静组、低氧安静组、常氧训练组、高住低训组。常氧安静组在常氧环境下安静生活;低氧安静组在氧浓度13.6%低氧舱内安静生活;常氧训练组和高住低训组进行4周的跑台运动,每天训练1 h,每周训练6 d。高住低训组晚上在氧浓度13.6%低氧舱内低氧暴露。结果:28 d后,与对照组比较,高住低训组骨骼肌总蛋白浓度显著下降(p<0.01),p70S6K蛋白表达显著增加(p<0.05),p70S6K(Thr389)磷酸化水平显著降低(p<0.01);常氧训练组p70S6K蛋白表达显著增加(p<0.05);低氧安静组p70S6K(Thr389)磷酸化水平显著降低(p<0.01)。结论:1)高住低训抑制了骨骼肌蛋白合成及p70S6K(Thr389)磷酸化,这也提示机体可能通过调节mTOR/p70S6K细胞信号转导通路来调节骨骼肌蛋白代谢;2)耐力运动提高了骨骼肌p70S6K蛋白的表达。
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| 关 键 词： | 高住低训 骨骼肌总蛋白 p70S6K p70S6K（Thr389） |
The Effects of Four Weeks Living High-Training Low on p70~(S6K) of Skeletal Muscle in Rats |
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| LI Xiao-hong,ZHAO Hua,ZENG Fan-xing.The Effects of Four Weeks Living High-Training Low on p70~(S6K) of Skeletal Muscle in Rats[J].Journal of Beijing Sport University,2010(3). |
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| Authors: | LI Xiao-hong ZHAO Hua ZENG Fan-xing |
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| Institution: | Beijing Sport University;Beijing 100084;China |
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| Abstract: | Objective: To explore the influence of hypoxic exercise on skeletal muscle protein and p70S6K in rats.Methods: SD rats are divided into four groups: control group,hypoxic group,normal exercise group and living high-training low(HiLo) group.Control group lives in normal environment quietly.Hypoxic group was traded with 13.6% oxygen concentration all the day,and live quietly.The other two groups take four weeks exercises,1hour/day,and 6 days/week.And HiLo group was traded with 13.6% oxygen concentration durin... |
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