| 递增负荷运动对大鼠肾上腺、甲状腺轴激素的影响 |
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| 引用本文： | 张洪海,王人卫,黄雅君,檀志宗.递增负荷运动对大鼠肾上腺、甲状腺轴激素的影响[J].北京体育大学学报,2008,31(1):50-52. |
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| 作者姓名： | 张洪海 王人卫 黄雅君 檀志宗 |
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| 作者单位： | 1. 上海体育科学研究所,上海,201100
2. 上海体育学院运动科学系,上海,200438 |
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| 摘 要： | 为研究递增运动负荷对大鼠下丘脑.垂体-肾上腺轴(HPA)与下丘脑一垂体一甲状腺轴(HPT)激素的影响,进一步探讨运动性月经失调(AMI)和HPA、HPT轴激素变化的关系.将成熟、健康的两月龄雌性S大鼠35只随机分为5组进行研究,结果发现:1)随着运动负荷递增,ACTH、PRL、TRH、TSH的水平逐渐升高,Ta大鼠阴道中底层细胞数量逐周增加,第七周最高;2)Ta组血ACIH、PRL与C组相比,存在显著性差异(P<0.05);Ta组血TSH和C组相比,存在显著性差异(P<0.01);,Tb组血TRH和C组相比,存在显著性差异(P<0.01).恢复一周后,ACTH、TRH的水平均有所下降.3)经过7周的递增负荷训练,Ta组大鼠肾上腺重量明显高于C组(P<0.01),休息一周后略有恢复,但仍高于C组(P<0.05);Ta组大鼠甲状腺重量明显低于C组(P<0.01).结论 :1)长期大强度运动导致HPA轴高度活化,肾上腺功能亢进,诱导AMI发生.2)长期大强度运动导致HPT轴功能紊乱,甲状腺功能减退,诱导AMI发生.3)提示:AMI是多器官多系统交互作用的结果,HPA轴高度活化、HPT轴功能紊乱及PRL水平升高均可导致AMI的发生.
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| 关 键 词： | 动情周期 促肾上腺皮质激素 促甲状腺激素释放激素 促甲状腺激素 催乳素 递增负荷运动 大鼠 肾上腺功能亢进 甲状腺轴 激素 影响 Hormones Changes Exercise Incremental Rats 作用 系统交互 多器官 甲状腺功能减退 功能紊乱 发生 活化 高度 大强度运动 |
| 文章编号： | 1007-3612(2008)01-0050-03 |
| 修稿时间： | 2006年4月21日 |
The Effect of Rats in Incremental Graded Exercise on Changes of HPA and HPT Hormones |
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| ZHANG Hong-hai,WANG Ren-wei,HUANG Ya-jun,TAN Zhi-zong.The Effect of Rats in Incremental Graded Exercise on Changes of HPA and HPT Hormones[J].Journal of Beijing Sport University,2008,31(1):50-52. |
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| Authors: | ZHANG Hong-hai WANG Ren-wei HUANG Ya-jun TAN Zhi-zong |
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| Abstract: | The research was conducted to investigate changes of Hypothalamo-Pituitary-Adrena(HPA) and Hypothalamo-Pituitary-Thyroid(HPT) hormones in incremental graded exercise,as well as the relation between changes of hormones 35 adults and healthy female SD rats were randomly divided into 5 groups.The experiments shows that: 1.The desquamated middle and bottom level cells of vagina increased week by week and reached the highest at seventh week in rats of Ta group;2.With the increase of exercise load,the level of ACTH,PRL,TRH and TSH increased gradually.ACTH and PRL of Ta group were significantly different with C group(P<0.05);TSH of Ta group were significantly different with C group(P<0.01);TRH of Tb group were significantly different with C group(P<0.01).After 1 week recovery,ACTH and TRH decreased significantly;3.With the increase of exercise load,the weight of adrenal increased,Ta group were significantly different with C group(P<0.01);The weight of thyroid decreased,the weight of thyroid of Ta group were significantly different with C group(P<0.05),after 1 week recovery,the weight of thyroid increased significantly.Conclusions are: 1.The results suggest that high intensity training conduced to excitation of HPA and adrenal,which induced to AMI;2.The results suggest that high intensity training conduced to turbulence of HPT and depression of thyroid,which induced to AMI;3.The results indicate that AMI was a result of interaction of many systems,excitation of HPA,turbulence of HPT and increase of PRL may induce to AMI. |
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| Keywords: | estrum ACTH PRL TRH TSH |
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