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1.
Abstract

Alpha-actinin-3 (ACTN3) is absent in 18% of healthy Caucasian individuals owing to homozygosity for a premature stop codon (X) at amino acid 577 (rs1815739). Previous studies have shown a strong association between ACTN3 genotype and human athletic performance. In a study of 452 young Chinese male soldiers, we examined the distribution of ACTN3 genotypes and alleles and analysed the association between ACTN3 genotypes and athletic performance. We found that the frequencies of the ACTN3 R577X genotype (RR 39.8%, RX 43.4%, and XX 16.8%) and R577X allele (R 61.5%, X 38.5%) in young Chinese males were not significantly different from those in Caucasians. We only observed a significant association (P = 0.025) between ACTN3 R577X genotypes and grip strength. Participants with the XX genotype displayed significantly lower handgrip strength than individuals with the RR genotype (P = 0.021), but the difference between XX and RX means (P = 0.258) and that between RR and RX means (P = 0.42) was not significant. We did not observe a strong association between the ACTN3 R577X genotypes and sprint phenotypes or endurance phenotypes. In conclusion, our results indicate that the ACTN3 R577X polymorphism is most strongly associated with grip strength in young Chinese male soldiers.  相似文献   

2.
Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16–2.18; P?=?.003). A significant linear correlation was found between the RR?+?RX genotype and athlete status (i.e. regional?P?=?.001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P?=?.030 for trend). Conclusions: The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR?+?RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR?+?RX genotype and long-distance running athletic status.  相似文献   

3.
目的：探讨ACTN3 R577X多态性与青少年运动员爆发力素质及其表型指标的关联性，并检验ACTN3 R577X作为分子标记在青少年运动员科学选材中应用的可行性。方法：选取上海地区青少年业余体校青少年运动员96名，其中男运动员58名，女运动员38名，根据项目特点分为爆发力组和耐力组；利用SNaPshot SNP分型技术对采集的DNA样本进行基因分型。爆发力组运动员进行立定跳远、原地纵跳指标的测试。结果：青少年爆发力组运动员ACTN3 R577X基因型分布与青少年耐力组运动员(x2=7.289，P<0.05)和对照组人群(x2=6.831，P<0.05)均存在显著性差异；青少年爆发力组运动员的ACTN3 R577X等位基因频率与青少年耐力组运动员(x2=7.498，P<0.01)和对照组人群(x2=7.923，P<0.01)均存在显著性差异。在青少年爆发力组男、女运动员中，RR、RX基因型运动员的立定跳远和原地纵跳成绩都要显著性高于XX基因型的运动员（P<0.05，P<0.01）。结论 ACTN3基因 R577X多态性与上海地区青少年运动员爆发力素质存在关联，ACTN3基因 R577X多态性与立定跳远、原地纵跳等爆发力素质表型指标存在关联，ACTN3 基因R577X多态性可以作为青少年速度力量型运动员选材的分子标记。  相似文献   

4.
PurposeThe aim of this study was to review, systematically, evidence concerning the link between the ACTN3 R577X polymorphism and the rates and severity of non-contact injuries and exercise-induced muscle damage in athletes and individuals enrolled in exercise training programs.MethodsA computerized literature search was performed in the electronic databases PubMed, Web of Science, and SPORTDiscus, from inception until November 2020. All included studies compared the epidemiological characteristics of non-contact injury between the different genotypes of the ACTN3 R577X polymorphism.ResultsOur search identified 492 records. After the screening of titles, abstracts, and full texts, 13 studies examining the association between the ACTN3 genotypes and the rate and severity of non-contact injury were included in the analysis. These studies were performed in 6 different countries (Spain, Japan, Brazil, China, the Republic of Korea, and Italy) and involved a total participant pool of 1093 participants. Of the studies, 2 studies involved only women, 5 studies involved only men, and 6 studies involved both men and women. All the studies included were classified as high-quality studies (≥6 points in the Physiotherapy Evidence Database (PEDro) scale score). Overall, evidence suggests there is an association between the ACTN3 R577X genotype and non-contact injury in 12 investigations. Six studies observed a significant association between ACTN3 R577X polymorphism and exercise induced muscle damage: 2 with non-contact ankle injury, 3 with non-contact muscle injury, and 1 with overall non-contact injury.ConclusionThe present findings support the premise that possessing the ACTN3 XX genotype may predispose athletes to a higher probability of some non-contact injuries, such as muscle injury, ankle sprains, and higher levels of exercise-induced muscle damage.  相似文献   

5.
The purpose of this study was to verify the association between ACTN3 polymorphism and physiological parameters related to endurance performance. A total of 150 healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to ventilatory threshold (VT) and respiratory compensation point (RCP). Participants were genotyped and divided into terciles based on the analysed variables. Genotype frequencies were compared through χ2 test between lower and higher terciles, with the lowest or highest values of each analysed variable. ACTN3 XX genotype was over-represented in higher tercile for VT and RCP. Odds ratio also showed significantly higher chances of XX individuals to be in higher tercile compared to RR (7.3) and RR + RX (3.5) for VT and compared to RR genotype (8.1) and RR + RX (3.4) for RCP. Thus, XX individuals could attain the VT and RCP at higher speeds, suggesting that they are able to sustain higher running speeds in lower exercise intensity domains. It could result in higher lipid acids oxidation, saving muscle glycogen and delaying the fatigue during prolonged exercises, which could be the advantage mechanism of this genotype to endurance performance.  相似文献   

6.
Ankle sprains are one of the most severe musculoskeletal soft tissue injuries during physical activity. Although many risk factors have been offered, it is unclear why some individuals develop noncontact ankle sprains when participating in comparable levels of physical exertion under identical environmental conditions and others do not. The ACTN3 gene that encodes the α-actinin-3 protein, which is, only expressed in the Z line of fast glycolytic muscle fibres was found to associate with power/strength performance. The aim of this study was therefore to investigate whether the ACTN3 gene polymorphism is associated with noncontact acute ankle sprains. One hundred and forty-two participants with clinically diagnosed noncontact acute ankle sprains as well as 280 physically active controls participants without any history of ankle sprains were included in this case–control genetic association study. The RR genotype (odds ratio (OR) = 0.56; 95% confidence interval (CI), 0.32–0.65, P = 0.011) and R allele (OR = 0.64; 95% CI, 0.37–0.68, P = 0.002) of the ACTN3 were significantly low-represented in the acute ankle sprains group compared with the control group. The ACTN3 R577X is associated with acute ankle sprains in Chinese participants in this study. This is the first study to suggest that an individual with a RR genotype is at a decreased risk of acute ankle sprains.  相似文献   

7.
目的:选取ACTN3基因C1747T多态位点进行解析,筛选中国举重运动员选材用分子标记.方法:提取94名中国北方汉族优秀举重运动员全血DNA,应用PCR-RFLP方法解析C1747T多态位点,通过X2检验与206名普通对照组进行分析.结果:94名中国北方汉族优秀举重运动员的C1747T多态位点的基因型分布经f检验符合H-W平衡(X2=2.04;df=2;P0. 05).优秀举重运动员组与普通时照组ACTN3基因C1747T多态位点的基因型分布具有显著性差异(P=0.031,P<0.05),等位基因分布也具有显著性差异(P=0.022,P<0. 05),与普通对照组(CC基因型:31%;C等位基因:56%)相比,举重运动员组CC基因型(47%)以及C等位基因(66%)的出现频率较高.结论:我国北方汉族人群ACTN3基因C1747T多态位点的CC基因型和C等位基因与优秀的力量素质显著相关.可以将ACTN3基因C1747T多态位点的CC基因型作为中国北方汉族举重运动员的选材用分子标记.  相似文献   

8.
BackgroundLow levels of antioxidant paraoxonase 1 (PON1) enzyme activity, PON1–Q192R polymorphism (a glutamine (Q) to arginine (R) substitution at position 192), PON1–L55M polymorphism (a leucine (L) to methionine (M) substitution at position 55), and oxidized low-density lipoprotein (oxLDL) are risk factors for coronary heart disease. Aerobic exercise improves PON1 activity, but the effects of hypoxic exercise are yet unclear. The aim of this study was to determine the effects of hypoxic underwater rugby training on PON1 activity and oxLDL levels and the role of the mentioned polymorphisms.MethodsSerum PON1 and arylesterase activities (ARE), PON1, PON3, and oxLDL protein levels (by using the enzyme-linked immunosorbent assays) were determined in an athletic group (42 trained male underwater rugby players; age = 21.7 ± 4.2 years, mean ± SD) and a control group (43 sedentary men; age = 23.9 ± 3.2 years). The polymorphisms were determined from genomic DNA samples.ResultsPON1 activity (25.1%, p = 0.052), PON3 (p < 0.001), and oxLDL (p < 0.001) of the athletic group, including most genotype groups, were higher than those of the control group. In comparison to the controls, PON1 activity levels (p = 0.005) of the PON1–Q192R homozygote QQ genotype group and PON1 activity levels (30%, p = 0.116) of the PON1–L55M homozygote LL genotype group were higher, whereas ARE activity values of athletic R allele carrier (Rc = QR + RR) (p = 0.005) and LL group (p = 0.002) were lower than the control genotype groups related to their polymorphisms.ConclusionHypoxic training can cause (1) significant oxidative stress, including oxLDL, and an antioxidant response (increase in PON1 activity and PON3), (2) differences in the activity of PON1 and ARE, which are modified by PON1–Q192R and PON1–L55M polymorphisms, respectively, and (3) improvements in PON1 activity of QQ and LL groups. However, hypoxic training can cause a disadvantage of LL and Rc groups for ARE.  相似文献   

9.
探讨中国越野滑雪运动员运动能力与CNTF基因多态性的关联性,为越野滑雪运动员的基因选材提供前期探讨性的理论依据与基础数据。方法：采用PCR—RFLP方法测定30名越野滑雪运动员与30名普通大学生的基因的多态性。结果：对照组等位基因频率为A=10．17％,G=88．13％,基因型频率为A／A=0％,A／G=20．69％,G／G=79．31％,越野滑雪运动员等位基因频率为A=20％,G=80％,基因型频率为A／A=6．67％,A／G=26．67％,G／G=66．67％。经卡方检验不符合Hardy—Weinberg遗传平衡定律,且CNTF基因型分布和等位基因与对照组的基因型频率和等位基因频率无统计学意义（P〉0．05）结论：CNTF基因的多态性与中国黑龙江省越野滑运动员运动能力无相关性。  相似文献   

10.
文章运用文献资料法、体质测量法、数理统计法和比较分析等研究方法,对阜阳市农村留守青少年学生的身体形态、身体机能和身体素质各指标进行监测,并与全国同龄人群进行比较分析。结果表明：阜阳市农村留守青少年学生身体形态发育水平低于全国同龄人群;身体机能各项指标平均数与全国同龄人群相比无统计学意义;身体素质各项指标中仅有16和18岁男生握力平均数以及男女学生耐力素质和柔韧素质呈显著性差异（P〈0.05）,其余年龄组握力和速度素质差异不显著。在此基础上文章从政府、学校和家庭三个方面提出提高阜阳市农村留守青少年学生体质状况的建议。  相似文献   

11.
Accurate measurement of head volume is indispensable for precise assessments of body composition determined by hydrostatic weighing without head submersion. The purpose of this study was to establish a prediction equation for head volume measured by the immersion method from multiple regression analysis using head parameters (head circumference, head length, head breadth, neck girth and head thickness) as independent variables. The participants were 106 Japanese young adults (55 males and 51 females) aged 17-27 years. Intra-class correlation coefficients (ICCs) for each head parameter and head volume in males and females were very high (ICC = 0.993-0.999, 0.992-0.998). Head circumference was closely related to head volume measured by the immersion method (r = 0.719, 0.861, P < 0.05), and was the most important parameter for the prediction equation in both sexes. Head breadth was related poorly (r = 0.475, 0.500, P < 0.05) and showed a small individual difference. It was, therefore, excluded from the independent variables. The prediction equation for males was predicted head volume = 122.10X1 + 106.19X3 + 37.16X4 - 89.46X5 - 4754.93, R = 0.909, SEE = 121.75 ml, and that for females was predicted head volume = 213.83X1 + 45.24X3 + 36.85X4 - 74.34X5 - 8912.43, R = 0.913, SEE = 136.26 ml (where X1 = head circumference, X3 = head length, X4 = neck girth, X5 = head thickness, and SEE = standard error of the estimate). The limits of agreement for predicted and measured head volume were -234.5 to 234.1 ml for males, and -261.0 to 261.0 ml for females. In cross-validation groups of both sexes, there were no significant differences between measured head volume and predicted head volume. The correlation coefficients between measured head volume and predicted head volume in males and females were 0.894 and 0.908, respectively. The predicted head volume from prediction equations was considered to have high reliability and validity.  相似文献   

12.
Abstract

A test was made of the general activation concept as it relates to strength performance. No difference in grip strength was found between an experimental group (N = 35), who performed maximal leg strength exercises between grip trials (in an attempt to raise their level of activation through induced muscular tension), and a control group (N = 35) who read between grip trials. Also, there was no difference in grip strength performance over trials for both groups. Intercorrelations of strength scores between limbs for the experimental group showed more specificity than generality. While these results fail to support a generalized activation effect in the static strength performance context, they do provide additional evidence of neuromuscular specificity in motor ability.  相似文献   

13.
Abstract

The aim of this study was to investigate the influence of mannose-binding lectin 2 (MBL2)-exon-1 gene polymorphisms on upper respiratory tract infection (URTI) incidence among endurance athletes. To this end, 100 healthy elite male athletes participating in the study were classified as either healthy or prone to frequent URTI. Blood samples, DNA isolation, multiplex polymerase chain reaction (PCR) and conventional PCR-RFLP were performed. Genomic DNA was extracted from peripheral leukocytes of whole blood samples using the QIAmp DNA Blood Mini Kit. For comparison of the distribution of genotypes between two groups and for estimating odds ratios (OR) for URTI susceptibility in relation to the MBL2-exon-1 polymorphism, Pearson's chi-square and logistic regression method were used, respectively. The MBL2-exon-1 genotype distribution differed between athletes with URTI and healthy athletes (χ2 = 7.81, p = 0.02). The AO and AO + OO genotypes of MBL2 were observed at a greater frequency in the illness-prone group compared with the healthy group (34.04% vs. 11.32%). In conclusion, findings from this study have identified a potential role of genetic variation in influencing the risk for URTI in athletic populations and single-nucleotide polymorphisms (SNPs) in the MBL2-exon-1 genes were associated with an altered risk profile. These measures may have a predictive value in the identification of individuals who are more likely to experience recurrent infections when exposed to high physical stress in the areas of athletic endeavour.  相似文献   

14.
目的：研究黑龙江汉族速滑运动员优秀耐力能力与肌型肌酸激酶基因（CKMM）A/G多态的关联性。方法：应用PCR-RFLP法测定120名黑龙江籍汉族健康大学生及25名黑龙江汉族耐力型速滑运动员CKMM基因A/G位点的基因型和等位基因的频率分布。结果：大学生等位基因频率为A=87%,G=13%,基因型频率为A/A=76%,A/G=22%,G/G=2%;速滑运动员等位基因频率为A=84%,G=16%,基因型频率为A/A=68%,A/G=32%,经卡方检验符合Hardy-Weinberg遗传平衡定律,两组的基因型频率和等位基因频率在男女间无显著性差异,与欧美人群相比有显著性差异,与我国北方汉族人及韩国人相比差异不具有显著性。两组间基因型频率和等位基因频率无显著性差异。结论：黑龙江汉族耐力型速滑运动员的优秀耐力素质与CKMM基因N coⅠ多态性无关,该位点不能作为其耐力素质选材的遗传学标记。  相似文献   

15.
Background: Evidence shows an association between grip strength and health;however, grip strength cut-offs for the detection of metabolic syndrome(MetS) in Latin American populations are scarce. The purpose of this study was to determine cut-offs of normalized grip strength(NGS)for the detection of MetS in a large nonrepresentative sample of a collegiate student population from Colombia.Methods: A total of 1795 volunteers(61.4% female;age = 20.68 ± 3.10 years, mean ± SD), ranging between 18 and 30 years of age participated in the study. Strength was estimated using a handheld dynamometer and normalized to body mass(handgrip strength(kg)/body mass(kg)). Anthropometrics, serum lipids indices, blood pressure, and fasting plasma glucose were measured. Body composition was measured by bioelectrical impedance analysis. MetS was defined as including ≥3 of the 5 metabolic abnormalities according to the International Diabetes Federation definition. A metabolic risk score was computed from the following components: waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood pressure.Results: Receiver operating curve analysis showed significant discriminatory accuracy of NGS in identifying the thresholds and risk categories.Lower strength was associated with increased prevalence of MetS. In males, weak, intermediate, and strong NGS values at these points were<0.466, 0.466-0.615, >0.615, respectively. In females, these cut-off points were <0.332, 0.332-0.437, >0.437, respectively.Conclusion: Our sex-specific cut-offs of NGS could be incorporated into a clinical setting for identifying college students at cardiometabolic disease risk.  相似文献   

16.
Abstract

Research concerned with predictors of talent in football has highlighted a number of potentially important and partially inherited measures such as body size, anaerobic power, aerobic capacity, agility, psychological profile, game intelligence and susceptibility to injuries. Genotyping for performance-associated DNA polymorphisms at an early age could be useful in predicting later success in football. The aim of the study was to investigate individually and in combination the association of common gene polymorphisms with football player’s status. A total of 246 Russian football players and 872 controls were genotyped for 8 gene polymorphisms, which were previously reported to be associated with athlete status. Four alleles (ACE D, ACTN3 Arg577, PPARA rs4253778 C and UCP2 55Val) were first identified, showing discrete associations with football player’s status. Next, we determined the total genotype score (TGS, from the accumulated combination of the 4 polymorphisms, with a maximum value of 100 for the theoretically optimal polygenic score) in athletes and controls. The mean TGS was significantly higher in football players (52.0 (17.6) vs. 41.3 (15.5); P < 0.0001) than in controls. These data suggest that the likelihood of becoming a football player depends on the carriage of a high number of “favourable” gene variants.  相似文献   

17.

Purpose

Following a cardiac event patients are at risk for deficits in mobility and function. However, measures of physical performance are not commonly used and have not been extensively studied in patients enrolled in cardiac rehabilitation. The purpose of this study was to determine the reliability and the minimal detectable change (MDC) of gait speed, 5 times sit to stand (5 STS) and hand grip strength for individuals enrolled in cardiac rehabilitation.

Methods

Forty-nine individuals enrolled in phase II or III cardiac rehabilitation participated in the study. Gait speed, 5 STS, and hand grip strength were measured over two sessions held on the same day. Intraclass correlation coefficient was used to determine reliability and MDC95 was calculated to measure responsiveness.

Results

All 3 measures showed high reliability (ICC for gait speed = 0.96, 5 STS = 0.87, right hand grip strength = 0.97, left hand grip strength = 0.97). The MDC95 for gait speed was 0.16 meters/second, 3.12 seconds for 5 STS, 5.2 kilograms for right and 5.1 kilograms for left hand grip strength.

Conclusion

Gait speed, 5 STS, and hand grip strength are reliable and responsive measures for patients in cardiac rehabilitation. Findings support their use in clinical practice and future cardiac rehabilitation studies.Key Words: cardiac rehabilitation, gait speed, sit to stand  相似文献   

18.
The aim of this study was to evaluate the utility of the RT3 accelerometer in young children, compare its accuracy with heart rate monitoring, and develop an equation to predict energy expenditure from RT3 output. Forty-two volunteers (mean age 12.2 years, s = 1.1) exercised at two horizontal and graded walking speeds (4 and 6 km.h(-1), 0% grade and 6% grade), and one horizontal running speed (8 km.h(-1), 0% grade), on a treadmill. Energy expenditure and oxygen consumption (VO2) served as the criterion measures. Comparison of RT3 estimates (counts and energy expenditure) demonstrated significant differences at 4, 6, and 8 km.h(-1) on level ground (P < 0.01), while no significant differences were noted between horizontal and graded walking at 4 and 6 km.h(-1). Correlation and regression analyses indicated no advantage of vector magnitude over the vertical plane (X) alone. A strong relationship between RT3 estimates and indirect calorimetry across all speeds was obtained (r = 0.633-0.850, P < 0.01). A child-specific prediction equation (adjusted R2 = 0.753) was derived and cross-validated that offered a valid energy expenditure estimate for walking/running activities. Despite recognized limitations, the RT3 may be a useful tool for the assessment of children's physical activity during walking and running.  相似文献   

19.
Worldwide, body weight has risen dramatically in recent decades, raising the question of whether there were concomitant changes in physical fitness. Past research with children and adolescents has shown that body weight and grip strength are positively correlated. Therefore, it was predicted that grip strength had increased on average in children and adolescents over the past four or five decades. To test this prediction, relevant data were extracted from 18 studies for males (N = 5676 in total) and 17 studies for females (N = 5489 in total). The studies were conducted in Canada and the United States from about 1966 on, with participants' ages ranging from 6 through 19 years. Weighted least squares regression analyses showed that grip strength was significantly predicted by age but not by country. Male grip strength decreased significantly over the period covered, but the change was very small, accounting for far less than 1% of the variance in male grip strength. Discussion focuses on potential explanations for why grip strength did not change over time as predicted.  相似文献   

20.
Abstract

The angiotensin converting enzyme (ACE) polymorphism is the most studied genetic marker in the field of human performance. There is a continuing debate in the literature regarding the possible association of ACE genotypes and elite athletic status. In fact, despite recent studies having identified no significant associations in athletes from mixed sporting disciplines, other researchers suggest that the insertion (I) variant may be associated with elite endurance performance, and the deletion (D) variant can be over-represented among elite sprinters. The purpose of the present study was to determine, for the first time, the association between the ACE genotypes and sprint athlete status among elite Italian gymnasts. To test this hypothesis, we assessed 33 elite Italian gymnasts (17 males, 16 females) and a control group of 53 (31 males, 22 females) unrelated sedentary individuals. DNA was extracted from each participant using a buccal swab and the ACE I/D polymorphism was determined using PCR while different amplified fragments were detected by electrophoresis using agarose gel and ethidium bromide staining. The ACE genotypes and allele frequencies among gymnasts (DD, ID, II=0.39, 0.48, 0.12, respectively; D allele=0.64) were not significantly different from those of Italian sedentary controls (DD, ID, II=0.39, 0.45, 0.15, respectively; D allele=0.62). However, the frequencies of our control group were similar to those observed in a sample of Italian sedentary individuals, and different to those of the general Caucasian population reported by other authors. Furthermore, the frequencies of our control group did not differ from those reported in other association studies involving elite sprint athletes. Our results suggest a lack of association between the ACE I/D polymorphism and elite gymnastics performance in Italians.  相似文献   

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