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高原地区由于独特的地理环境和气候条件,从而引起各种高原疾病。尿酸增高在临床上比较常见,为了给诊断和治疗提供理论指导,本文对尿酸增高患者进行了原因分析,现分析报道如下。 相似文献
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直播密度对富锌水稻锌含量及生理生化特性的影响 总被引：1，自引：0，他引：1
研究了不同直播密度对富锌水稻籽粒中锌含量及茎、叶、籽粒内在生理生化特性(如超氧化物歧化酶(SOD)、苯丙氨酸解氨酶(PAL)、多酚氧化酶(PPO)、过氧化氢酶(CAT)的活性及叶绿素含量等)的影响。试验结果表明,直播密度对富锌水稻籽粒的锌含量有一定影响,随着直播密度的增加,锌含量呈下降趋势,而对各种酶的酶活影响不大。试验还发现,叶中各种酶的活性最高,茎次之,籽粒中最低。从总体来看,富锌水稻以播种量7500-8250 kg/km2为宜,此时富锌水稻植株中各种酶的活性、叶绿素和锌含量都较大。 相似文献
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在科学技术的发展引导下,自动化控制系统已经和现代化电力控制结合,在自动控制系统的应用下,实现了弱电控制强电。但是由于自动化系统自身的应用较为繁琐,应该按照系统应用中的要求,对整个系统应用控制中的方法应用分析,保障在方法应用控制分析中,能够为整个控制技术的实施提供保障。鉴于此,针对自动化控制中弱电控制强电的方法分析进行了研究,首先,针对本文研究的自动化控制弱电、强电定义进行了分析,其次,就本文研究的自动化控制中弱电控制强电环节分析做出了研究,最后,就本文研究中自动化控制中弱电控制强电的方法应用给出了分析。希望在本文的研究帮助下,能够为自动化控制中弱电控制强电的方法应用提供参考。 相似文献
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随着我们生活水平提高,居民膳食结构提高、同时生活习惯发生改变。随之而来的高血压的患病率也大大增加,同时高血压引起肾损害导致尿酸升高都是显而易见的,但同时与其相关的高尿酸血症也是导致高血压的一个独立危险因素,尿酸是高血压发病的中介体,高尿酸血症在高血压发病以及预后过程中起着非常重要的作用,高血压的危险性会随着尿酸水平的增加而增加。在干预尿酸水平对治疗高血压有着举足轻重的意义,据统计,有20%的高尿酸血症患者同时患有高血压,而高血压患者中有大概三分之一患有高尿酸血症。很多人都把这两种病单独看待,而事实是,高血压和高尿酸血症的病情变化和治疗是相互影响的。下来就高尿酸与高血压的关系做一个粗浅的简述。 相似文献
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痛风(gout)是长期嘌呤代谢障碍和(或)尿酸排泄减少所致血尿酸增高的一组临床综合征.了解与嘌呤代谢有关酶活性的改变,与编码转运尿酸相关蛋白基因的突变以及尿酸盐结晶诱导的炙性反应机制,对痛风的诊断治疗具有重要意义. 相似文献
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Uric acid in urine was analyzed using porcine liver uricase and horseradish peroxidase immobilized on alkylamine and arylamine
glass beads (pore diameter 55nm) respectively. The minimum detection limit was 5.0mg/0.1 ml urine. The recovery of added uric
acid was 92%. Within and between assay CVS were <1.3% and <5.3% respectively. A good correlation (r=0.93) was found between
urinary urate values obtained by a commercial kit method and the present method. The uric acid in 24hr urine of apparently
healthy adults and person sufering from various diseases was found to be 450 to 900mg/24hr, 659mg/24hr (range, mean) and 910–1400mg/24hr,
1145 mg/24hr (range, mean) respectively with the present method. 相似文献
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Pasalic D Marinkovic N Feher-Turkovic L 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2012,22(1):63-75
With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms. 相似文献
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Mridula Mahajan Sukhraj Kaur Shruti Mahajan Ravi Kant 《Indian journal of clinical biochemistry : IJCB》2009,24(2):205-207
Uric acid an endogenous aqueous antioxidant in normal humans is present in much higher concentrations than vitamin C and has
been known to cover 2/3rd of the free radical scavenging capacity in plasma. In the present study average uric acid levels of patients of rheumatoid
arthritis were found to be close to the normal individuals. A unique feature was observed after classifying the patients on
the basis of the duration of suffering, the patients having longer duration of disease had least uric acid levels as compared
to those suffering from relatively lesser period, similar trend was observed in the ascorbic acid estimations. The decline
in uric acid values with progression of the disease was much more than what was observed in case of ascorbic acid suggesting
the significant role of uric acid in scavenging of free radicals. Too much lowering of Uric Acid should be checked and vitamin
C should be supplemented in diet for maintaining the balance between pro oxidant and antioxidant forces to check pro oxidant
insult in rheumatoid arthritis. 相似文献
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Kiran Chaudhari S. Khanzode S. Khanzode G. Dakhale A. Saoji S. Sarode 《Indian journal of clinical biochemistry : IJCB》2010,25(1):77-81
Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective
Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined.
This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale
for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects
before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly
diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more
significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant
and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= −0.864,
P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid
and improves Hamilton Rating Scale for Depression score in major depressive disorder. 相似文献
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Hanaa B. Atya Sahar A. Ali Mohamed I. Hegazy Fathia Z. El Sharkawi 《Indian journal of clinical biochemistry : IJCB》2018,33(2):163-170
Urine is a proven source of metabolite biomarkers and has the potential to be a rapid, noninvasive, inexpensive, and efficient diagnostic tool for various human diseases. Despite these advantages, urine is an under-investigated source of biomarkers for multiple sclerosis (MS). The objective was to investigate the level of some urinary metabolites (urea, uric acid and hippuric acid) in patients with MS and correlate their levels to the severity of the disease, MS subtypes and MS treatment. The urine samples were collected from 73 MS patients-48 with RRMS and 25 with SPMS- and age matched 75 healthy controls. The values of urinary urea, uric acid and hippuric acid in MS patients were significantly decreased, and these metabolites in SPMS pattern showed significantly decrease than RRMS pattern. Also showed significant inverse correlation with expanded disability status scale and number of relapses. Accordingly, they may act as a potential urinary biomarkers for MS, and correlate to disease progression. 相似文献
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Serum CRP and uric acid levels were estimated in twenty-five patients with psoriasis (group III) before and after 12 weeks
of treatment. Results were compared with a group of 25 normal subjects (group I) and a group of 25 patients of various skin
diseases other than psoriatic lesion (group II). Mean value for CRP was found to be increased by more than 20 folds in patients
with psoriasis, which was subsequently reduced to nearly 50% of the initial value after 12 weeks of treatment. These patients
also showed hyperuricemia. Nearly 25% of these patients also exhibited arthritis. It is thus suggested that both CRP and uric
acid levels should be monitored in patients with psoriasis. 相似文献
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Urinary abnormalities were evaluated in 100 renal stone patients with first episode of renal stone having age 22 to 45 years
from both sex and compared to 100 normal healthy control group having same age group from both sex. Twenty-four hours urinary
oxalate, calcium, uric acid, sodium, magnesium, phosphorus and citrate were estimated. The urinary pH was also determined.
In stone formers urinary oxalate, calcium, sodium and uric acid excretions were significantly higher when compared with control
group. Whereas citrate, phosphate and magnesium excretion were significantly lower in stone formers when compared with control.
The pH of urine in stone formers was lower than the controls. High dietary intake of purine rich diet causes elevated excretion
of uric acid, which leads to calcium oxalate crystal formation and precipitation. Other risk factors such as urinary oxalate,
calcium also related to formation of renal calculi.
Hypocitraturia is the main cause of renal calculi along with hypomagnesiuria and hypophosphaturia in the patient of Marathwada
region. On the basis of urinary abnormalities further stone formation in the patient can be prevented by dietary modifications. 相似文献
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K. Poornima M. Cariappa K. Asha H. P. Kedilaya M. Nandini 《Indian journal of clinical biochemistry : IJCB》2003,18(2):197-205
An adequate antioxidant reserve which is usually present in a vegetarian diet is associated with higher life expectancy. On
the other hand habitual consumption of fish is associated with lower risk of cardiovascular diseases which is attributed to
the polyunsaturated fatty acids (PUFA) present in it. However the PUFA are readily susceptible to oxidation leading to the
formation of free radicals which is known to be involved in the causation of several diseases.
The oxidant-antioxidant status of 23 vegetarians and 22 fish eaters was studied by determining the plasma lipid peroxides
measured as malondialdehyde (MDA) and the antioxidants, viz. glutathione (GSH), ascorbic acid, ceruloplasmin and uric acid.
Results show that the ascorbic acid values were significantly higher in vegetarians. In addition, MDA correlated negatively
with ascorbic acid only in vegetarians. However, correlation of MDA with glutathione showed a significant negative correlation
only in fish eaters. There was no statistically significant difference in the MDA, GSH, ceruloplasmin and uric acid levels.
The mechanism behind these findings are not clear and needs to be explored. 相似文献
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Benedicta D’Souza Vivian D’Souza S. Sowmya G. Seema C. N. Hemalatha M. Anu G. Sajana 《Indian journal of clinical biochemistry : IJCB》2008,23(3):218-222
The study was conducted to find out the extent of lipid peroxidation and antioxidant status in ischemic stroke patients (ISPs)
with and without diabetes. Malondialdehyde (MDA) was studied as a marker of lipid peroxidation. Glutathione (GSH), uric acid
and ceruloplasmin were estimated to study the antioxidant potential of ISPs. Significantly higher levels of MDA were found
in both the groups of ISPs and the increase in MDA was more in ISPs without diabetes. GSH levels were decreased significantly
in both the groups of ISPs and maximum decline was found in ISPs with diabetes. Uric acid levels were significantly increased
in both the groups of ISPs. Ceruloplasmin levels were increased significantly in ISPs without diabetes, whereas its levels
were slightly decreased in ISPs with diabetes. A negative correlation was found between MDA and the antioxidants GSH, uric
acid and ceruloplasmin in ISPs with diabetes. This study suggests that there is an association between ischemic stroke and
increased oxidative stress and the antioxidant potential is impaired in both the groups of ISPs with and without diabetes. 相似文献
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Pallab Basu Sabyasachi Som Nabendu Choudhuri Harendranath Das 《Indian journal of clinical biochemistry : IJCB》2008,23(4):361-364
A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to
see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis
by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls.
A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found
that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients,
a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = −0.857,
P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same
time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of
asphyxia by Apgar score. 相似文献