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1.
通过口服免疫药物后，对虾血清中溶菌酶、酚氧化酶（ＰＯ）活力及免疫保护率测定，来作为衡量对虾免疫状态的指标，并用弧菌疫苗浸泡法及口服免疫药物，提高虾体自身免疫能力，增强疾病抵抗力。 相似文献
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在国家自然科学基金委重点项目资助下,王金星课题组针对对虾养殖业中病害防控的实际需求,围绕着对虾免疫系统与细菌和病毒性两类重要病原(鳗弧菌和白斑综合征病毒)之间的相互作用开展研究,取得了系列创新性成果:(1)揭示了对虾抵御病原入侵的细胞和分子机制。主要阐释了不同的模式识别受体识别和防御病原的机理,包括FcLec4通过行使调理素的功能促进对病原的吞噬、Leulectin不同识别模块之间在抗细菌免疫中分工与协作的新机理、MjHeCL感知血淋巴菌群及参与菌群动态平衡调控的机理以及清道夫受体参与的抗病毒免疫的新途径等;(2)发现了病原侵入机体后宿主细胞抵御病原的信号途径及效应机制。主要揭示了对虾Toll和IMD信号途径的特点、调控机理及下游的效应分子,阐释了JAK/STAT途径激活的特征及调控的下游效应分子,并发现Toll途径的激活机制不同于果蝇而与哺乳动物相似;(3)阐明了胞内病原逃逸宿主免疫的分子机制。阐释了白斑综合征病毒利用宿主的C-型凝集素以胆固醇依赖的方式入侵宿主细胞的分子机理以及利用宿主的SUMO化系统促进自身复制的机理。该研究为对虾养殖的病害防治提供了新思路、新方法、新的候选药物以及对虾抗病品系培育的新靶标。 相似文献
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抗炎免疫药物主要用于多种伴有免疫功能障碍的慢性炎症性疾病。当前,在很大程度上是瞩目于对类风湿关节炎(RA)有针对性疗效药物的探寻。尽管新型药物不断出现,但就对治疗RA来说,未能取得有突破性的进展,这主要与RA病因和发病机理尚不清楚有关。因而深化对RA病因和发病机理的认识,不仅对于寻找新型有效的抗RA药物,而且对合理应用现有的药物均有重要意义。一、RA的病理生理学进展 RA是一种以关节滑膜炎为特征的、原因不完全明了的全身性疾病。血管炎病变可累及全身各个器官,故本病又称为类风湿病。RA的发病可能与患者遗传基因的变异有关。调查 相似文献
5.
本文对葱属植物对动物特异性免疫-细胞免疫和体液免疫及非特异性免疫-免疫器官、自然杀伤性细胞等方面的调节作用进行了综述, 为开发、应用新型免疫制剂及饲料添加剂提供了科学理论基础. 相似文献
6.
免疫应答的基本模式及其起源 总被引：3，自引：0，他引：3
免疫应答基本模式为体内存在静息免疫细胞库，抗原选择性激活其中特异性细胞，活化的有关细胞胺阶段发出和接受调控信号，增殖分化形成效应细胞和因子，主要诱使作用对象发生转化或清除。这揭示最初免疫应答与发育调控有关。 相似文献
7.
赵凡 《科技成果管理与研究》2010,(4):6-6
赵法箴院士是我国知名的水产养殖学家、“中国对虾”（又称对虾、明虾、东方对虾）养殖业的主要创始人之一。自1954年走进山东大学水产系后的那一刻他便与水产养殖业结下了不解之缘，并将自身全部的热情和精力投入了他为之奋斗一生并引以为豪的对虾养殖业。多年来他主持和承担完成的“对虾人工育苗及精养高产技术的研究”、“对虾工厂化全人工育苗技术”、“对虾人工配合饵料的研究”分获全国科学大会奖、国家科学技术进步一、二等奖。 相似文献
8.
生物效应调节剂(Biological Reoponse Modifiers, BRMs)是一类新药,此类药物是通过激发或调节非特异性的免疫应答过程,或通过纠正紊乱的生长和变异过程,从而达到修复机体本身的防御体系。BRMs包括免疫增强剂、免疫修复剂、细胞激活素(Cytokines)等。对于免疫缺陷引起的疾患,首先考虑应用此类药物。亦可作为癌症的治疗药物,因为它可通过提高宿主对癌细胞的非特异性免疫原而产生有效的反应,达到治疗目的。经过几年的努力,BRMs的研究有了很大进展,最引人注目的是淋巴细胞或巨噬细胞等的产物:细胞激活素。免疫反应的调节是通过各种淋巴细胞的亚单位相互作用进行的,这些相互作用又常常是通过细胞激活素的产生、分泌和特异性识别中介的。它是一类能调节免疫反应的激素样蛋白质。本文侧重对有治疗意义或治疗价值的细胞激活素加以简要综述。 相似文献
9.
对平衡的m阶相关免疫函数进行了研究，得到了两个重要结果：一个是平衡函数满足m相关免疫的充要条件，另一个是当m≥2/3n时，f（x）都是平衡的布尔函数。 相似文献
10.
正专家简介:周联,教授,博士生导师,广州中医药大学中药学院副院长,中国免疫学会理事,中国免疫学会中医药免疫分会主任委员,广东省免疫学会副理事长,无限极中草药免疫研究中心首席研究员。长期从事中西医结合基础研究,主要研究方向是中医药免疫,以及中药免疫药理及毒理,一直进行相关研究和教学工作,尤其关注中医药免疫与人类健康。曾参与国家 相似文献
11.
给出了多连接查询优化问题的计算模型,分析了免疫遗传算法的基本原理,提出将免疫遗传算法应用于多连接查询优化问题。针对多连接查询优化问题的具体特点,给出了免疫遗传算法的设计,包括亲和度、适应度函数的设计,基于抗体浓度的选择算子、交叉算子、变异算子的设计,免疫算子的设计。 相似文献
12.
揭示了信用与利率双重风险免疫原理,建立了基于信用与利率双重风险免疫的资产组合优化模型,解决了传统利率免疫条件不能反映信用等级迁移风险的问题。本文的创新与特色是建立了同时控制利率风险和信用等级迁移风险的优化模型。通过揭示市场利率的变化和信用等级迁移的变化共同引起贷款等资产现值的变化的规律性联系,建立了同时反映利率风险免疫和信用等级迁移风险免疫的双重风险免疫条件,同时控制了利率风险和贷款的信用风险,避免了在企业信用等级迁移和市场利率发生变化时银行净值的波动,克服了传统免疫条件忽略信用风险的不足,开辟了资产优化配置研究的新思路,保证了市场利率波动时银行股东权益不受损失。 相似文献
13.
M. H. Meshkibaf A. Ebrahimi R. Ghodsi A. Ahmadi 《Indian journal of clinical biochemistry : IJCB》2006,21(1):161-164
A number of newly developed antiepileptic drugs are currently in use, among them Lamotrigine (LTG) is more common. Despite
the extensive use of this drug, it has not been possible to predict the side effects especially the hepatotoxic reactions
after long-term treatment. The present study was designed to find out alterations in the activities of liver enzymes after
chronic exposure of rats to different dose of LTG. Adults male (Wistar) rats were treated orally with LTG [5 mg/kg body weight
or 25 mg/kg body wt.] for 60 days. After the experimental period, auto analyzer carried out liver function tests. The liver
histopathology was obtained after scarifying the rats. There was a significant increase in the level of ALP, AST, ALT and
bilirubin at therapeutic dose of LTG. The increase level of these enzymes and bilirubin at toxic dose were much higher and
significant. However, the total protein and albumin significantly decreased at toxic dose of LTG. Elevation of liver enzymes
and bilirubin after chronic exposure of rats to high dose of LTG reflects hepatocellular damage that may lead to hepatitis.
It is concluded that regular liver function and drug monitoring should follow the treatment with LTG. 相似文献
14.
M. Maneesh Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):138-142
Infertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this
condition. The study was conducted to determine the effects of alpha tocopherol on ethanol induced testicular injuries in
male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily
1.6g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6g ethanol+80mg alpha tocopherol/kg body weight/day
for four weeks orally. Group IV received 1.6g ethanol/kg body weight for/day 4 weeks and followed by 80mg alpha tocopherol/kg
body weight/day for four weeks orally. Group V received 1.6g ethanol/kg body weight/day orally for 4 weeks, followed by 4
weeks abstinence. Twently-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were
removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes.
Alpha tocopherol treatment increased the activities of testicularΔ
5, 3β-HSD. Moreover, the treatment was also associated with significant decrease in testicular oxidative stress. Ethanol-induced
oxidative stress and decreased steroidogenesis can be reversed by treatment with alpha tocopherol. 相似文献
15.
Sarika Amdekar Vinod Singh Avnish Kumar Poonam Sharma Rambir Singh 《Indian journal of clinical biochemistry : IJCB》2014,29(4):471-478
Arthritis is an inflammatory disease of joints. Exact etiology of the disease is not understood yet; but histopathological examination of vital organs like liver, kidney, ovary and knee joint can anticipate immune mediated damage. In this study, Lactobacillus acidophilus was administered orally by both prophylactic and curative protocol in freund’s complete adjuvant induced arthritic rats. Indomethacin was used as standard anti-arthritic drug. Histopathology of liver, kidney, ovary and right hind knee joint were done. Cytokine concentrations were determined by using ELISA. Effects shown by L. acidophilus were comparable with indomethacin. Histopathological analysis of liver, kidney, ovaries and knee joints of L. acidophilus fed groups revealed significantly less damage as compared with other counterparts. Lactobacillus treatment has down-regulated pro-inflammatory level and up-regulated anti-inflammatory cytokines level in serum samples. L. acidophilus managed organs damage associated with arthritis. It has significantly down regulated the pro-inflammatory cytokines. 相似文献
16.
Swati Banerjee E Raji Nair Satish Kumar M. V. R. Reddy Bhaskar C. Harinath 《Indian journal of clinical biochemistry : IJCB》2001,16(2):203-206
Analysis of tubercular antibody, circulating free and immune complexed antigen (CIC-Ag) was done in confimed pulmonary tuberculosis
sera by ELISA, using ES-31 antigen and affinity purified anti ES-31 antibody. Twenty three of 25 (92%) tuberculosis sera were
positive for IgG antibody to ES-31 antigen. Using anti ES-31 antibody, free tubercular antigen could be detected in 20 of
25 (80%) cases whereas circulating immune complexed antigen (CIC-Ag) in 18 of 25 (72%) cases by sandwich ELISA. Of the two
sera showing absence of antibody, one showed presence of free and CIC-Ag whereas the other showed the presence of free antigen.
Thus antigen assay may be used as an adjunct tool for confirmation of pulmonary tuberculosis. 相似文献
17.
Increased oxidative stress is a widely accepted participant in the development and progression of diabetes and its complications.
The present study has been undertaken to evaluate oxidative stress in type 2 diabetes mellitus and effect of vitamin E supplementation
on oxidative stress. In all 120 subjects were enrolled in the present study, 40 subjects are age and sex matched controls.
Test group comprised of clinically diagnosed (n = 80) type 2 diabetic patients. Biochemical parameters like serum MDA, nitric oxide, superoxide dismutase, erythrocyte reduced
glutathione and platelet aggregation were analyzed in control and diabetic group. Test group is further categorized as Group
I (n = 40) diabetics were treated by only hypoglycemic drugs and Group II (n = 40) diabetics were treated by hypoglycemic drugs with vitamin E supplementation. All above biochemical parameters were
again reassessed after 3 months follow-up in both group and its values were compared with its respective baseline levels.
The study shows, reduction of oxidative stress, improvement in antioxidant enzymes and endothelial dysfunction in group II,
those were on treatment of hypoglycemic drugs along with vitamin E supplementation. Hence the present study may conclude that
vitamin E supplementation along with hypoglycemic drugs may be beneficial to type 2 DM patients to minimize vascular complications. 相似文献
18.
采用不同剂量的天然防腐保鲜剂给小鼠灌胃，造成小鼠急性中毒。用组织病理学及组织化学方法观察小鼠肝组织的结构变化。实验结果表明用药组小鼠肝细胞明显变性，肝血窦扩张变窄，肝细胞肿胀，呈明显的空泡状。ＰＡＳ反应显示肝细胞内有超常量的肝糖原累积。 相似文献
19.
Three orally active hypoglycemic compounds Kakara Ib, IIIa1 and IIIb1 were purified from the unripe fruits ofMomordica charantia Linn (bitter gourd). Powder of the dried fruits was extracted with benzene and the extract was purified further by sillicic acid column chromatography. They were homogeneous by HPLC. Kakara Ib (400 mg/kg), IIIa1 (100 mg/kg) and IIIb1 (300 mg/kg) improved glucose tolerance in subdiabetic (alloxan recovered) rabbits in acute (single dose) and subacute (10 days) studies. When compared with tolbutamide, Kakara Ib was less active, IIIa1 was more potent and IIIb1 was equal in activity. Two hyperglycemic compounds were also present. 相似文献
20.
Sherman S 《Endeavour》2004,28(4):156-160
The English translation of Pierre Pomet's A Compleat History of Druggs (1712) demonstrates how the expansion of print culture altered the way that scientific ideas were communicated. Although it makes utilitarian claims, the text of the History departs from the style of contemporary British pharmacopoeias by emphasizing the exotic aspects of drugs. In this sense, the text exemplifies how Enlightenment science could be sold to a cross-over audience interested as much in the fantastical as in the quality and operation of drugs. 相似文献