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1.
Abstract

The aim of this study was to examine the effect of exercise intensity on coincidence anticipation timing [CAT] performance at different stimulus speeds. Fourteen young adults (11 males and 3 females) volunteered to participate in the study following ethical approval. After familiarisation, coincidence anticipation was measured using the Bassin Anticipation Timer under three conditions: rest, moderate-intensity and high-intensity exercise with stimulus speeds of 3, 5 and 8 mph, set using an incremental running protocol until the participants reached a steady state of 70% and 90% of heart rate reserve (HRR), respectively. Results indicated a significant exercise intensity×stimulus speed interaction (p=0.0001) for absolute error (AE). There were no significant differences in AE across exercise intensities at a stimulus speed of 3 mph (p>0.05). AE was poorer during high-intensity exercise (90% HRR) compared to rest (p=0.022), and moderate-intensity (70% HRR) exercise (all, p=0.004 or better) at 5 and 8 mph. Variable error (VE) was similar across exercise intensities at stimulus speeds of both 3 and 5 mph (p>0.05). At a stimulus speed of 8 mph, VE was significantly poorer during high-intensity exercise compared to rest (p=0.006) and moderate-intensity exercise (p=0.008). There were no significant differences for constant error (p>0.05) across exercise intensities or stimulus speeds. High-intensity exercise is associated with poorer CAT performance. However, stimulus speed plays a key role within this association where faster stimulus speeds were associated with a more marked decrease in coincidence anticipation performance.  相似文献   

2.
The purpose of this study was to examine the accuracy of the ePulse Personal Fitness Assistant, a forearm-worn device that provides measures of heart rate and estimates energy expenditure. Forty-six participants engaged in 4-minute periods of standing, 2.0 mph walking, 3.5 mph walking, 4.5 mph jogging, and 6.0 mph running. Heart rate and energy expenditure were simultaneously recorded at 60-second intervals using the ePulse, an electrocardiogram (EKG), and indirect calorimetry. The heart rates obtained from the ePulse were highly correlated (intraclass correlation coefficients [ICCs] ≥0.85) with those from the EKG during all conditions. The typical errors progressively increased with increasing exercise intensity but were <5 bpm only during rest and 2.0 mph. Energy expenditure from the ePulse was poorly correlated with indirect calorimetry (ICCs: 0.01-0.36) and the typical errors for energy expenditure ranged from 0.69-2.97 kcal · min(-1), progressively increasing with exercise intensity. These data suggest that the ePulse Personal Fitness Assistant is a valid device for monitoring heart rate at rest and low-intensity exercise, but becomes less accurate as exercise intensity increases. However, it does not appear to be a valid device to estimate energy expenditure during exercise.  相似文献   

3.
男子400m跑运动员气体代谢的适应性变化特征   总被引：1，自引：0，他引：1  
通过对男子400m跑运动员及普通男子大学生在递增负荷运动过程中气体代谢变化的比较研究发现,运动过程中400m跑运动员VO2和VO2/HR始终大于普通大学生,VEO2小于普通大学生;运动开始阶段运动员VO2、VCO2及VO2/HR指标增加速度相对较快;中等强度运动时,实验组RQ、VCO2增长速度略高于VO2增长速度,但无显著性差异;而对照组VCO2及RQ增加速度明显高于VO2;大负荷运动时,运动员VO2、VCO2、RQ及VO2/HR绝对值及增加速度明显大于对照组。  相似文献   

4.
Abstract

The purpose of this study was to examine the accuracy of the ePulse Personal Fitness Assistant, a forearm-worn device that provides measures of heart rate and estimates energy expenditure. Forty-six participants engaged in 4-minute periods of standing, 2.0 mph walking, 3.5 mph walking, 4.5 mph jogging, and 6.0 mph running. Heart rate and energy expenditure were simultaneously recorded at 60-second intervals using the ePulse, an electrocardiogram (EKG), and indirect calorimetry. The heart rates obtained from the ePulse were highly correlated (intraclass correlation coefficients [ICCs] ≥0.85) with those from the EKG during all conditions. The typical errors progressively increased with increasing exercise intensity but were <5 bpm only during rest and 2.0 mph. Energy expenditure from the ePulse was poorly correlated with indirect calorimetry (ICCs: 0.01–0.36) and the typical errors for energy expenditure ranged from 0.69–2.97 kcal · min?1, progressively increasing with exercise intensity. These data suggest that the ePulse Personal Fitness Assistant is a valid device for monitoring heart rate at rest and low-intensity exercise, but becomes less accurate as exercise intensity increases. However, it does not appear to be a valid device to estimate energy expenditure during exercise.  相似文献   

5.
Sixteen female games players completed 15 min of intermittent exercise on a treadmill. The speed and incline of the treadmill were varied to elicit a similar heart rate response to that found during women's hockey match‐play. The mean heart rate response was 169 ± 8 beats min‐1 and the mean work:rest ratio was 1:1.7. Oxygen uptake was estimated by applying the oxygen cost determined from an individual's heart rate‐oxygen uptake regression equation to the average heart rate each 5 s during the intermittent exercise. A second esimation of oxygen uptake was made from a time‐motion analysis by assigning a specific oxygen cost to each discrete movement during the intermittent exercise protocol. The true oxygen cost was calculated from the analysis of the expired gas. The heart rate analysis overestimated the true cost by a mean of 4.3 ± 5.3% (0.09 ± 0.11 1 min‐1), and the time‐motion analysis underestimated the true value by a mean of 15.7 ± 6.3% (0.34 ± 0.15 1 min‐1). There was a significant difference (P < 0.01) between the true value and both the estimates. It was concluded that heart rate analysis gives a much better indication of oxygen uptake during intermittent activity than time‐motion analysis.  相似文献   

6.
In this study, we examined the effects of different work:rest durations during 20 min intermittent treadmill running and subsequent performance. Nine males (mean age 25.8 years, s = 6.8; body mass 73.9 kg, s = 8.8; stature 1.75 m, s = 0.05; VO(2max) 55.5 ml x kg(-1) x min(-1), s = 5.8) undertook repeated sprints at 120% of the speed at which VO(2max) was attained interspersed with passive recovery. The work:rest ratio was constant (1:1.5) with trials involving either short (6:9 s) or long (24:36 s) work:rest exercise protocols (total exercise time 8 min). Each trial was followed by a performance run to volitional exhaustion at the same running speed. Testing order was randomized and counterbalanced. Heart rate, oxygen consumption, respiratory exchange ratio, and blood glucose were similar between trials (P > 0.05). Blood lactate concentration was greater during the long than the short exercise protocol (P < 0.05), whereas blood pH was lower during the long than the short exercise protocol (7.28, s = 0.11 and 7.30, s = 0.03 at 20 min, respectively; P < 0.05). Perceptions of effort were greater throughout exercise for the long than the short exercise protocol (16.6, s = 1.4 and 15.1, s = 1.6 at 20 min, respectively; P < 0.05) and correlated with blood lactate (r = 0.43) and bicarbonate concentrations (r = 0.59; P < 0.05). Although blood lactate concentration at 20 min was related to performance time (r = - 0.56; P < 0.05), no differences were observed between trials for time to exhaustion (short exercise protocol: 95.8 s, s = 30.0; long exercise protocol: 92.0 s, s = 37.1) or physiological responses at exhaustion (P > 0.05). Our results demonstrate that 20 min of intermittent exercise involving a long work:rest duration elicits greater metabolic and perceptual strain than intermittent exercise undertaken with a short work:rest duration but does not affect subsequent run time to exhaustion.  相似文献   

7.
Abstract

Central core temperature, energy cost and pulmonary ventilation, heart rate, and sweat loss were measured on 5 football players while exercising on a motor driven treadmill at 6 mph for 20 min. Comparisons were made while subjects wore a football uniform and a hospital scrub suit. Core temperature was measured by a rectal thermistor inserted 4 in. into the rectum, energy cost and pulmonary ventilation by open circuit spirometry, heart rate by telemetry, and sweat loss by pre- and postexercise weight changes.

Core temperature, sweat loss, and peak exercise and end recovery heart rates while running in the uniform were significantly elevated compared to the scrub suit controls. Energy cost and pulmonary ventilation were greater (not significant) in the uniform primarily because of the added weight and, to a lesser degree, the reduction in available evaporative surface area.  相似文献   

8.
The aim of this study was to devise a laboratory-based protocol for a motorized treadmill that was representative of work rates observed during soccer match-play. Selected physiological responses to this soccer-specific intermittent exercise protocol were then compared with steady-rate exercise performed at the same average speed. Seven male university soccer players (mean +/- s: age 24 +/- 2 years, height 1.78 +/- 0.1 m, mass 72.2 +/- 5.0 kg, VO2max 57.8 +/- 4 ml x kg(-1) x min(-1)) completed a 45-min soccer-specific intermittent exercise protocol on a motorized treadmill. They also completed a continuous steady-rate exercise session for an identical period at the same average speed. The physiological responses to the laboratory-based soccer-specific protocol were similar to values previously observed for soccer match-play (oxygen consumption approximately 68% of maximum, heart rate 168 +/- 10 beats x min(-1)). No significant differences were observed in oxygen consumption, heart rate, rectal temperature or sweat production rate between the two conditions. Average minute ventilation was greater (P < 0.05) in intermittent exercise (81.3 +/- 0.2 l x min(-1)) than steady-rate exercise (72.4 +/- 11.4 l x min(-1)). The rating of perceived exertion for the session as a whole was 15 +/- 2 during soccer-specific intermittent exercise and 12 +/- 1 for continuous exercise (P < 0.05). The physiological strain associated with the laboratory-based soccer-specific intermittent protocol was similar to that associated with 45 min of soccer match-play, based on the variables measured, indicating the relevance of the simulation as a model of match-play work rates. Soccer-specific intermittent exercise did not increase the demands placed on the aerobic energy systems compared to continuous exercise performed at the same average speed, although the results indicate that anaerobic energy provision is more important during intermittent than during continuous exercise at the same average speed.  相似文献   

9.
The aim of this study was to devise a laboratory-based protocol for a motorized treadmill that was representative of work rates observed during soccer match-play. Selected physiological responses to this soccer-specific intermittent exercise protocol were then compared with steady-rate exercise performed at the same average speed. Seven male university soccer players (mean - s : age 24 - 2 years, height 1.78 - 0.1 m, mass 72.2 - 5.0 kg, VO 2max 57.8 - 4 ml·kg -1 ·min -1 ) completed a 45-min soccer-specific intermittent exercise protocol on a motorized treadmill. They also completed a continuous steady-rate exercise session for an identical period at the same average speed. The physiological responses to the laboratory-based soccer-specific protocol were similar to values previously observed for soccer match-play (oxygen consumption approximately 68% of maximum, heart rate 168 - 10 beats·min -1 ). No significant differences were observed in oxygen consumption, heart rate, rectal temperature or sweat production rate between the two conditions. Average minute ventilation was greater ( P ? 0.05) in intermittent exercise (81.3 - 0.2l·min -1 ) than steady-rate exercise (72.4 - 11.4l·min -1 ). The rating of perceived exertion for the session as a whole was 15 - 2 during soccer-specific intermittent exercise and 12 - 1 for continuous exercise ( P ? 0.05). The physiological strain associated with the laboratory-based soccer-specific intermittent protocol was similar to that associated with 45 min of soccer match-play, based on the variables measured, indicating the relevance of the simulation as a model of match-play work rates. Soccer-specific intermittent exercise did not increase the demands placed on the aerobic energy systems compared to continuous exercise performed at the same average speed, although the results indicate that anaerobic energy provision is more important during intermittent than during continuous exercise at the same average speed.  相似文献   

10.
Abstract

The present study attempted to determine whether the nature of training experiences influences the development of coincident timing skill in young children. The task involved visual tracking of a moving light sequence and a 43 cm arm movement to a padded target. Subjects attempted to tap the target coincident with the completion of the light sequence. Sixty first grade children were randomly assigned to one of five groups, with an equal number of males and females in each group. Subjects assigned to the training groups received 48 trials on each of two days, with stimulus speeds that were either slow (179 cm/sec or 4 mph), fast (313 cm/sec or 7 mph), varied-random (179, 224, 268, 313 cm/sec or 4, 5, 6, 7 mph), or varied-blocked (i.e., 6 consecutive trials with one speed before changing to another). Control subjects performed a neutral coloring activity during the training phase of the experiment. All subjects were then given 10 trials on a third day with each of two stimulus speeds not experienced previously; one slow (134 cm/sec or 3 mph) and one fast (358 cm/sec or 8 mph). During transfer trials all groups were more accurate with the fast than with the slow speed stimulus. Training method mattered most during slow speed transfer trials, with the most accurate performance demonstrated by the group receiving varied-blocked speeds during training. The least effective methods were fast speed training, especially for males, and varied-random speed training. It was concluded that training sessions for the development of coincident timing skill in young children should emphasize slower speed stimuli and blocking of additional speeds which are more rapid.  相似文献   

11.
Walking is a safe, accessible and low cost activity, amenable to change and known to have great potential to increase physical activity levels in sedentary individuals. The objective of this study is to estimate the proportion of the 2009 adult population of England who would attain or exceed vigorous intensity activity (>70% maximum heart rate [HR(max)]) by walking at 3 mph. We conducted predictive impact modelling using participants' (n = 1741, aged 25-64 years) cardiovascular fitness data from treadmill walking tests. We combined this data with English population estimates adjusted for age and sex to estimate the numbers of individuals that would exceed 70% HR(max) (an intensity considered sufficient for fitness gains) when walking at 3 mph (4.8 km · h(-1)). We estimate 1.5 million men (95% confidence interval [CI] 0.9-2.2 million) (from 13.4 million corresponding to 11.6% (95% CI 7.0-16.2%)) and 3.9 million women (95% CI 3.0-4.8 million) (from 13.6 million corresponding to 28.6% (95% CI 22.0-35.1%)) in England aged 25-64 years would benefit from regularly walking at 3 mph. In total, a projected 5.4 million individuals (95% CI 3.9-6.9 million) aged 25-64 (from 26.97 million corresponding to 20.1% (95% CI 14.6-25.7%)) could benefit from walking at 3 mph. Our estimates suggest a considerable number of individuals in the English population could receive fitness and health benefits by walking regularly at 3 mph. Physical activity messages that promote walking at this speed may therefore have the potential to significantly impact national fitness levels and health in England.  相似文献   

12.
马继政  孙飙  牛洁  韩峰 《体育学刊》2004,11(2):132-135
采用脉冲多谱勒超声心动图观察运动中和运动后左室舒张功能的变化。研究结果显示运动时随强度的增加舒张早期最大的峰值速度E峰峰值流速、舒张晚期最大的峰值速度A峰峰值流速，舒张早期最大瞬时压差(PPGE)、舒张末期最大瞬时压差(PPGA)增加，但vE／vA值下降。其动力来源可能与运动时左室的收缩功能提高有关。运动后恢复期E峰、A峰峰值流速，PPGE、PPGA逐渐减少，vE／vA值逐渐增大，并很快恢复到安静状态。  相似文献   

13.
The aim of this study was to establish a graded exercise test protocol for determining the peak physiological responses of female outrigger canoeists. Seventeen trained female outrigger canoeists completed two outrigger ergometer graded exercise test protocols in random order: (1) 25 W power output for 2 min increasing by 7.5 W every minute until exhaustion; and (2) 25 W power output for 2 min increasing by 15 W every 2 min to exhaustion. Heart rate and power output were recorded every 15 s. Expired air was collected continuously and sampled for analysis at 15-s intervals, while blood lactate concentration was measured immediately after and 3, 5, and 7 min after exercise. The peak physiological and performance variables examined included peak oxygen uptake (VO2peak), minute ventilation, tidal volume, ventilatory thresholds 1 and 2, respiratory rate, respiratory exchange ratio, heart rate, blood lactate concentration, power output, performance time, and time to VO2peak. There were no significant differences in peak physiological responses, ventilatory thresholds or performance variables between the two graded exercise test protocols. Despite no significant differences between protocols, due to the large limits of agreement evident between protocols for the peak physiological responses, it is recommended that the same protocol be used for all comparison testing to minimize intra-individual variability of results.  相似文献   

14.
Abstract

Walking is a safe, accessible and low cost activity, amenable to change and known to have great potential to increase physical activity levels in sedentary individuals. The objective of this study is to estimate the proportion of the 2009 adult population of England who would attain or exceed vigorous intensity activity (>70% maximum heart rate [HRmax]) by walking at 3 mph. We conducted predictive impact modelling using participants' (n = 1741, aged 25–64 years) cardiovascular fitness data from treadmill walking tests. We combined this data with English population estimates adjusted for age and sex to estimate the numbers of individuals that would exceed 70% HRmax (an intensity considered sufficient for fitness gains) when walking at 3 mph (4.8 km · h?1). We estimate 1.5 million men (95% confidence interval [CI] 0.9–2.2 million) (from 13.4 million corresponding to 11.6% (95% CI 7.0–16.2%)) and 3.9 million women (95% CI 3.0–4.8 million) (from 13.6 million corresponding to 28.6% (95% CI 22.0–35.1%)) in England aged 25–64 years would benefit from regularly walking at 3 mph. In total, a projected 5.4 million individuals (95% CI 3.9–6.9 million) aged 25–64 (from 26.97 million corresponding to 20.1% (95% CI 14.6–25.7%)) could benefit from walking at 3 mph. Our estimates suggest a considerable number of individuals in the English population could receive fitness and health benefits by walking regularly at 3 mph. Physical activity messages that promote walking at this speed may therefore have the potential to significantly impact national fitness levels and health in England.  相似文献   

15.
采用脉冲多谱勒超声心动图观察恒定运动中和运动后左室舒张功能的变化,研究结果显示100w强度运动时舒张早期最大峰值速度E峰峰值流速、舒张晚期最大峰值速度A峰峰值流速、舒张早期最大瞬时压差PPGE、舒张末期最大瞬时压差PPGA显著大于50w,100w强度运动时E/A值显著小于50w.运动后恢复期E峰、A峰、PPGE、PPGA逐渐减少,E/A值逐渐增大,并很快恢复到安静状态.结论:其动力来源和运动时左室的收缩功能提高有关.  相似文献   

16.
The aims of this study were: (1) to identify the exercise intensity that corresponds to the maximal lactate steady state in adolescent endurance-trained runners; (2) to identify any differences between the sexes; and (3) to compare the maximal lactate steady state with commonly cited fixed blood lactate reference parameters. Sixteen boys and nine girls volunteered to participate in the study. They were first tested using a stepwise incremental treadmill protocol to establish the blood lactate profile and peak oxygen uptake (VO2). Running speeds corresponding to fixed whole blood lactate concentrations of 2.0, 2.5 and 4.0 mmol x l(-1) were calculated using linear interpolation. The maximal lactate steady state was determined from four separate 20-min constant-speed treadmill runs. The maximal lactate steady state was defined as the fastest running speed, to the nearest 0.5 km x h(-1), where the change in blood lactate concentration between 10 and 20 min was < 0.5 mmol x l(-1). Although the boys had to run faster than the girls to elicit the maximal lactate steady state (15.7 vs 14.3 km x h(-1), P < 0.01), once the data were expressed relative to percent peak VO2 (85 and 85%, respectively) and percent peak heart rate (92 and 94%, respectively), there were no differences between the sexes (P > 0.05). The running speed and percent peak VO2 at the maximal lactate steady state were not different to those corresponding to the fixed blood lactate concentrations of 2.0 and 2.5 mmol x l(-1) (P > 0.05), but were both lower than those at the 4.0 mmol x l(-1) concentration (P < 0.05). In conclusion, the maximal lactate steady state corresponded to a similar relative exercise intensity as that reported in adult athletes. The running speed, percent peak VO2 and percent peak heart rate at the maximal lactate steady state are approximated by the fixed blood lactate concentration of 2.5 mmol x l(-1) measured during an incremental treadmill test in boys and girls.  相似文献   

17.
The aim of this study was to assess the validity (Study 1) and reliability (Study 2) of a novel intermittent running test (Carminatti's test) for physiological assessment of soccer players. In Study 1, 28 players performed Carminatti's test, a repeated sprint ability test, and an intermittent treadmill test. In Study 2, 24 players performed Carminatti's test twice within 72 h to determine test-retest reliability. Carminatti's test required the participants to complete repeated bouts of 5 × 12 s shuttle running at progressively faster speeds until volitional exhaustion. The 12 s bouts were separated by 6 s recovery periods, making each stage 90 s in duration. The initial running distance was set at 15 m and was increased by 1 m at each stage (90 s). The repeated sprint ability test required the participants to perform 7 × 34.2 m maximal effort sprints separated by 25 s recovery. During the intermittent treadmill test, the initial velocity of 9.0 km · h(-1) was increased by 1.2 km · h(-1) every 3 min until volitional exhaustion. No significant difference (P > 0.05) was observed between Carminatti's test peak running velocity and speed at VO(2max) (v-VO(2max)). Peak running velocity in Carminatti's test was strongly correlated with v-VO(2max) (r = 0.74, P < 0.01), and highly associated with velocity at the onset of blood lactate accumulation (r = 0.63, P < 0.01). Mean sprint time was strongly associated with peak running velocity in Carminatti's test (r = -0.71, P < 0.01). The intraclass correlation was 0.94 with a coefficient of variation of 1.4%. In conclusion, Carminatti's test appears to be avalid and reliable measure of physical fitness and of the ability to perform intermittent high-intensity exercise in soccer players.  相似文献   

18.
ABSTRACT

Purpose: Badminton is a sport characterized by high-intensity activity interspersed with short rests requiring specific physiological fitness, skills and game tactics. This study aimed to develop, describe and establish the reliability of a novel badminton intermittent exercise protocol, to simulate singles match-play (Part A) and assess match-fitness (Part B). Method: Twelve well-trained male badminton players performed a two-part protocol, mimicking the demands and activity of match-play, on two occasions with at least 72-h recovery. Part A imitated match-play and consisted of 40 stages alternating between 20 s work – receiving shuttlecocks from a launcher and ghosting (simulated) actions – and 40 s rest. Part B was an open-ended period, challenging match-fitness, designed to exhaust participants within 10 min. Physiological responses (heart rate, blood lactate and ratings of perceived exertion) (Part A and B) and time to exhaustion (Part B) were determined both times. Results: There were no differences in performance and physiological responses between trials (p > .05). The protocol demonstrated excellent reliability (intraclass correlation coefficient > 0.89) for all variables. Time to exhaustion (Part B) was 198 ± 98 s and 194 ± 82 s, respectively. Mean (Part A) and peak (Part B) heart rates were 166 ± 9; 191 ± 8 b?min?1 and 166 ± 9; 191 ± 7 b?min?1 and blood lactate concentrations (Part B) 11.8 ± 2.3 and 11.5 ± 2.1 mmol?l?1 for trials 1 and 2, respectively. Conclusion: The protocol reliably induces match-like responses and can be used to assess match-fitness for training/research purposes.  相似文献   

19.
Oxygen uptake (VO2) during treadmill exercise is directly related to the speed and grade, as well as the participant's body weight. To determine whether body composition also affects VO2 (ml.kg-1.min-1) during exercise, we studied 14 male body builders (M weight = 99 kg, SD = 7; M height = 180 cm, SD = 8; M body fat = 8%, SD = 3; M fat free mass = 91 kg, SD = 7) and 14 weight-matched men (M weight = 99 kg, SD = 9; M height = 179 cm, SD = 5; M body fat = 24%, SD = 5; M fat free mass = 73 kg, SD = 9). Percentage of body fat, t(13) = 8.185, p < .0001, and fat free mass, t(13) = 5.723, p < .0001, were significantly different between groups. VO2 was measured by respiratory gas analysis at rest and during three different submaximal workrates while walking on the treadmill without using the handrails for support. VO2 was significantly greater for the lean, highly muscular men at rest: 5.6 +/- 1 vs. 4.0 +/- 1 ml.kg-1.min-1, F(1, 26) = 21.185, p < .001; Stage 1: 1.7 mph/10%, 18.5 +/- 2 vs. 16.1 +/- 2 ml.kg-1.min-1, F(1, 26) = 6.002, p < .05; Stage 2: 2.5 mph/12%, 26.6 +/- 3 vs. 23.1 +/- 2 ml.kg-1.min-1, F(1, 26) = 7.991, p < .01; and Stage 3:3.4 mph/14%, 39.3 +/- 5 vs. 33.5 +/- 5 ml.kg-1.min-1, F(1, 26) = 7.682, p < .01, body builders versus weight-matched men, respectively. However, net VO2 (i.e., exercise VO2 - rest VO2) was not significantly different between the two groups at any of the matched exercise stages. The findings from this study indicate that VO2 during weight-bearing exercise performed at the same submaximal workrate is higher for male body builders compared to that measured in weight-matched men and that which is predicted by standard equations. These observed differences in exercise VO2 appear to be due to the higher resting VO2 in highly muscular participants.  相似文献   

20.
BackgroundDelirium is a neurocognitive disorder characterized by an abrupt decline in attention, awareness, and cognition after surgical/illness-induced stressors on the brain. There is now an increasing focus on how cardiovascular health interacts with neurocognitive disorders given their overlapping risk factors and links to subsequent dementia and mortality. One common indicator for cardiovascular health is the heart rate response/recovery (HRR) to exercise, but how this relates to future delirium is unknown.MethodsElectrocardiogram data were examined in 38,740 middle- to older-aged UK Biobank participants (mean age = 58.1 years, range: 40–72 years; 47.3% males) who completed a standardized submaximal exercise stress test (15-s baseline, 6-min exercise, and 1-min recovery) and required hospitalization during follow-up. An HRR index was derived as the product of the heart rate (HR) responses during exercise (peak/resting HRs) and recovery (peak/recovery HRs) and categorized into low/average/high groups as the bottom quartile/middle 2 quartiles/top quartile, respectively. Associations between 3 HRR groups and new-onset delirium were investigated using Cox proportional hazards models and a 2-year landmark analysis to minimize reverse causation. Sociodemographic factors, lifestyle factors/physical activity, cardiovascular risk, comorbidities, cognition, and maximal workload achieved were included as covariates.ResultsDuring a median follow-up period of 11 years, 348 participants (9/1000) newly developed delirium. Compared with the high HRR group (16/1000), the risk for delirium was almost doubled in those with low HRR (hazard ratio = 1.90, 95% confidence interval (95%CI): 1.30–2.79, p = 0.001) and average HRR (hazard ratio = 1.54, 95%CI: 1.07–2.22, p = 0.020)). Low HRR was equivalent to being 6 years older, a current smoker, or ≥3 additional cardiovascular disease risks. Results were robust in sensitivity analysis, but the risk appeared larger in those with better cognition and when only postoperative delirium was considered (n = 147; hazard ratio = 2.66, 95%CI: 1.46–4.85, p = 0.001).ConclusionHRR during submaximal exercise is associated with future risk for delirium. Given that HRR is potentially modifiable, it may prove useful for neurological risk stratification alongside traditional cardiovascular risk factors.  相似文献   

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