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1.
Amitabha Ray Anil Kumar Bahadur S. L. Dayalu Naik Bhuvnesh Kumar Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(2):199-202
Endogenous oestrogens are thought to be involved in breast cancer, but few studies could show the direct relationship between
hormones and pathological process of the disease. In the present study, oestradiol was estimated in the serum of pre-and postmenopausal
breast cancer patients along with normal healthy controls and patients with carcinoma of the uterine cervix which is not dependent
on oestrogens. Premenopausal patients with breast cancer showed higher levels of oestradiol as compared to premenopausal control
women as well as cervical cancer patients. Whereas, no statistically significant differences were observed in serum oestradiol
levels amongst postmenopausal groups of breast cancer, cervical cancer and normal women. The result of the study reflects
the association of oestradiol as well as its difference in the pathological events of pre and postmenopausal breast cancer. 相似文献
2.
Sharmila Upadhya Subramanya Upadhya D. M. Vasudevan 《Indian journal of clinical biochemistry : IJCB》2003,18(1):46-51
The study was designed to evaluate the significance of tissue polypeptide specific antigen (TPS) in patients with histologically
proven ovarian and colorectal cancer following treatment along with CA125 (in ovarian cancer) and CEA (in colorectal cancer).
Patients were grouped as follows:
In patients with ovarian and colorectal cancer, the mean TPS levels were significantly higher in patients of group II compared
to group I. The percentage of patients above cut-off levels for TPS were 17.4% in group I and 95.5% in group II. Similar results
were observed with the mean levels of CA125. In colorectal cancer patients, the percentage of patients above cut-off levels
for CEA and TPS were 70% and 30% in group I and 100% in group II for both the markers. Our observations indicate that TPS
may be used as a common marker to indicate metastases in patients with ovarian and colorectal cancer. 相似文献
| Group I | : Patients with stable disease |
| Group II | : Patients with metastasis and relapse |
3.
4.
D. Jain A. Ray A. K. Bahadur K. U. Chaturvedi R. Sood S. Sharma S. L. D. Naik B. K. Sharma 《Indian journal of clinical biochemistry : IJCB》2001,16(1):42-51
There are numerous growing evidences of resemblance between carcinomas of the breast and prostate. A total of 45 cases of
these two hormone-dependent cancers along with appropriate controls were subjected for status of epidermal growth factor receptors
as well as serum lipid profile. Paraffin embedded tissue sections from aforesald tumours were analysed by immunohistochemical
staining for epidermal growth factor receptor (EGF-R), c-erbB-2 oncoprotein, estrogen receptor (ER) and progesterone receptor
(PgR). Sera from same individuals were studied for serum lipid profile analysis. The study revealed that immunoexpression
of all receptor proteins (EGF-R). c-erbB-2 was significantly higher in breast carcinoma. In addition, mean levels of triglycerides,
total cholesterol, LDL-cholesterol were found to be significantly elevated while the level of HDL-cholesterol was observed
to be lower among patients with breast cancer as compared to matched controls. Further, ER-positive breast cancer cases have
significantly higher mean level of HDL-cholesterol when compared with ER-negative breast cancer patients. Contrary to this,
no alteration in different serum lipid fractions was noticed among the patients with prostate cancer. However, a positive
relationship was noticed between immunoexpressions of EGF-R and c-erbB-2 in prostate cancer. 相似文献
5.
J. Pramanik A. N. Lodam C. M. Badole M. V. R. Reddy K. R. Patond B. C. Harinath 《Indian journal of clinical biochemistry : IJCB》2000,15(1):22-28
Trichloroacetic acid (TCA) solubilized and DEAE fractionatedMycobacterium tuberculosis H37Ra excretory-secretory (ES) antigen viz., Mtb EST DE1 and affinity purified goat antibodies to the TCA solubilized ES antigen
(Mtb EST) were explored in detecting tubercular antibody and antigen respectively in sera of bone and joint tuberculosis by
indirect and sandwich ELISA. Out of total 36 bone & joint tuberculosis cases, tubercular antibody was detected by indirect
ELISA in 30 patients (sensitivity 83%), while circulating tubercular antigen was detected by sandwich ELISA in 27 patients
(sensitivity 75%). Out of 34 non tubercular disease control cases, 10 patients showed positive reaction for antibody while
only 4 patients showed positive reaction for antigen. In another group of 34 healthy subjects who were screened, 4 individuals
showed positive reaction for tubercular antibody and 2 cases for antigen. This study shows that antigen detection assay using
affinity purified anti Mtb EST antigen antibody is superior with overall specificity of 91% as compared to antibody detection
assay with 75% specificity in bone & joint tuberculosis. 相似文献
6.
Sharmila Upadhya Subramanya Upadhya K. S. Prabhu 《Indian journal of clinical biochemistry : IJCB》2002,17(1):20-24
The present study was done to assess the levels of glycoconjugates and ceruloplasmin in sera of patients with cervical cancer.
Serum hexoses, hexosamines, sialic acid and fucose are elevated in a variety of inflammatory and neoplastic conditions. All
the glycoconjugates, except fucose were increased in serum of patients compared to controls. Also, hexoses and sialic acid
levels were high in patients with later stages of cancer compared to patients with early stage disease (P=<0.0001, P=0.03).
Serum ceruloplasmin was increased in patients with early stage cancer (51.5mg/dl) and with late stage cancer (61mg/dl) compared
to controls (38mg/dl). The elevated glycoconjugates may be the result of inflammatory reaction associated with neoplasia,
as serum ceruloplasmin (an acute phase reactant) is also increased in these patients. 相似文献
7.
R. L. Gupta K. Ramachandran Monika J. S. Chowhan 《Indian journal of clinical biochemistry : IJCB》1996,11(1):59-61
Urinary excretion of beta-aminoisobutyric acid (BAIB), was determined in 28 active and 12 inactive bladder cancer patients.
Mean excretion of BAIB was higher in active cancer patients-187.8 mg/24 hours whereas it was 120.4 mg/24 hours in inactive
cancer patients. The increased BAIB excretion in both disease groups was independent of tumour stage. BAIB appears to be a
useful diagnositic aid in the assessment of bladder cancer patients. 相似文献
8.
Y. P. Singh O. P. Sachdeva S. K. Aggarwal K. Chugh Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2008,23(3):290-292
Blood glutathione was estimated in fifty patients of head and neck cancer in the age group of 18–76 years and the results
were compared with a group of normal healthy controls. Mean blood glutathione level was found to be significantly lowered
in patients than the controls. Irrespective of the site, TNM classification, histopathology, and character of lesion, fall
in blood glutathione was nearly same in all the patients. The mean level was significantly increased after radiotherapy when
compared with the levels before radiotherapy. The decreased levels of GSH in-patients with head and neck cancer, observed
in the present study, may be due to its increased utilization by the cells. The results suggest that patients with head and
neck cancer have increased oxidative stress. 相似文献
9.
The present study was undertaken to investigate the relation of retinol with lipid profile of patients with cancers of breast,
stomach, oesophagus, colon, gallbladder, pancreas, lung and cervix. Serum retinol was assayed in 120 patients and 40 healthy
normal control by reverse phase HPLC using CLC-ODS C-18 columns and retinyl acetate as an internal standard.
Significant decease in serum cholesterol and LDL was observed in patients with cancers of esophagus, colon, stomach, pancreas
and gallbladder respectively.
Retinol was reduced in all forms of cancers but pronounced decrease was observed in oesophagus, gallbladder, pancreas, stomach
and colon. Serum Retinol in all patients was directly correlated with total cholesterol and LDL. These findings suggest that
therapeutic modalities of this vitamin could be planned for these patients, as vitamin A is known to act as an antioxidant
for prevention of certain cancers. 相似文献
10.
目的：观察心理干预对癌症患者生活质量的影响。方法：将72例癌症患者随机分为两组,对照组采用常规治疗,干预组在常规治疗基础上进行心理干预;干预后进行生活质量核心量表（EORTC QLQ-C30）测定。结果：干预后两组患者QLQ-C30评分比较差异有统计学意义（P〈0.05）;干预组患者评分均明显优于对照组（P〈0.05）。结论：心理干预对癌症患者生活质量的提高有重要意义。 相似文献
11.
Lakshmi Krishnamoorthy Elizabeth Zachariah P. G. Ramaswamy N. Anantha 《Indian journal of clinical biochemistry : IJCB》1994,9(1):37-39
Circulating levels of gonadotropins (FSH,LH), prolactin (PRL), estradiol and progesterone were measured by radioimmunoassay
in the sera of 60 patients with histopathologically proven breast cancer. 30 patients belonged to the post and 30 to the premenopausal
group. 30 healthy women, 15 each in the pre and post menopausal groups served as controls for the study.
Prolactin was elevated in 33% and 26% of pre and post menopausal breast cancer patients respectively. Lower levels of estradiol
and progesterone were observed during the luteal phase of the menstrual cycle in premenopausal breast cancer patients. Among
postmenopausal patients with breast cancer, LH was elevated in 32%, FSH in 15% and estradiol in 30% of the patients studied. 相似文献
12.
VEGF、PTN在肺癌患者外周血及胸腔积液中表达及其意义 总被引：1，自引：0，他引：1
目的:以45名肺癌伴胸腔积液患者,50名肺癌组不伴胸腔积液患者,以及19名健康人为研究对象,探讨VEGF、PTN在肺癌患者外周血及胸腔积液中表达及其意义.方法:以ELISA法测定胸腔积液中VEGF及PTN表达水平.结果:肺癌伴胸腔积液组患者胸腔积液及外周血中VEGF、PTN表达水平明显高于肺癌不伴胸腔积液组和健康对照组外周血.差异有统计学意义(P＜0.05).结论:肺癌患者胸腔积液及外周血中VEGF、PTN表达明显升高,可能通过某一共同机制促进肿瘤转移、恶化. 相似文献
13.
Fasting blood sample of 50 normal subjects (control) and 100 patients of breast cancer were investigated for serum total cholesterol,
high density lipoprotein cholesterol, low density lipoprotein cholesterol, very low density lipoprotein, high density lipoprotein
cholesterol:low density lipoprotein cholesterol ratio and total cholesterol:high density lipoprotein cholesterol ratio during
breast cancer of women. Five cancer stages, types, age groups, parity and menopausal status were undertaken for the study.
It was observed that there was a significant rise in serum total cholesterol and low density lipoprotein cholesterol whereas
high density lipoprotein cholesterol and very low density lipoprotein cholesterol were not significant. The ratio of high
density lipoprotein cholesterol:low density lipoprotein cholesterol and total cholesterol:high density lipoprotein cholesterol
values increased significantly in breast cancer patients. 相似文献
14.
Rani James K. Thriveni Girija Ramaswamy Lakshmi Krishnamoorthy Geetashree Mukherjee P. P. Vijayalaxmi Deshmane P. P. Bapsy 《Indian journal of clinical biochemistry : IJCB》2008,23(4):345-351
HER-2 is overexpressed in approximately 20–30% of invasive Breast Cancer. ECD of the HER-2 protein is frequently cleaved and
released into the circulation, where it can be detected by ELISA in up to 45% of patients with metastatic breast cancer. The
objective of our study was to compare the current methods for the detection of HER-2 protein. Tissue HER-2 levels were studied
in 100 breast cancer patients by IHC and compared with serum HER-2 levels by ELISA. IHC frequency was 29%. Serum HER-2 ECD
was positive in 42% of patients. A statistically significant correlation was observed. HER-2 detected by IHC correlates significantly
with serum HER-2 levels detected by ELISA. Thus, ELISA is a reliable and economical tool to assess the HER-2 status in tumors,
when breast tissue sample is not available. 相似文献
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16.
The case control study was conducted to quantify the amount of the carcinogenic tobacco specific nitrosamine in smokeless tobacco users and smokers in patients with oral leukoplakia and also to emphasize the role of tobacco-specific nitrosamine in the incidence of oral leukoplakia. The study was conducted on 30 patients. The urine samples were obtained from smokeless tobacco users with oral leukoplakia, smokers with oral leukoplakia and non-tobacco users (i.e. people who do not use tobacco in any form). The collected samples were processed by gas chromatography-mass spectrometry. A highly significant difference of NNAL[4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol] in smokeless tobacco users than tobacco smokers P = 0.0002 (Table 1) was obtained. This significant difference shows smokeless tobacco is more carcinogenic than smoked tobacco. This study confirmed that NNAL is a potent biomarker for calculating the risk of occurrence of carcinoma in smokeless tobacco users and smokers, and that smokeless tobacco is more harmful than smoked tobacco. 相似文献
17.
Roland Einarsson 《Indian journal of clinical biochemistry : IJCB》1999,14(2):109-116
Tissue polypeptide specific antigen (TPS) measures an antigenic determinant associated with human cytokeratin 18. TPS is a
marker of tumor cell activity in contrast to markers related to tumor burden. The value of detecting circulating TPS lies
in the early detection of recurrence by serial determinations and in the rapid assessment of the efficacy of the treatment.
Pretreatment levels of TPS in patients with metastatic breast cancer are related with prognosis. Decreasing TPS levels during
therapy monitoring indicate response and a fast response is correlated to favourable prognosis. Increasing TPS levels, in
the presence of clinically stable disease or partial remission, predict disease progression with a considerable lead-time.
Improved effectiveness in breast cancer management can be seen when TPS is used in combination with CA 15-3. When tumor marker
determinations are applied in a proper way in the appropriate situation, the results can assist the oncologist. Thus monitoring
of therapy in patients with metastatic breast cancer should be based upon serial TPS and CA 15-3 determinations in serum.
The use of tumor marker determinations in the early follow-up interval following surgery to detect early tumor recurrence
may be simpler, more sensitive and less expensive than imaging methods. 相似文献
18.
Orathai Tangvarasittichai Watchiravut Jaiwang Surapon Tangvarasittichai 《Indian journal of clinical biochemistry : IJCB》2015,30(1):55-58
Increased levels of plasma DNA have frequently been noticed in the blood plasma of cancer patients. The possibility of using plasma DNA level as the indicator of tumor stage in breast cancer was investigated in plasma samples obtained from 100 breast cancer patients and 100 healthy women who were included as controls. Circulatory plasma free DNA was extracted from plasma samples and quantified by fluorometer. The median concentration of plasma DNA in the plasma samples from breast cancer patients classified by TNM staging system as stage I, II, III, IV and breast surgical patients were 0.5, 235, 422, 1,280 and 0.5 ng/ml, respectively. The level of plasma DNA in the stage II- IV group was significantly higher than those in the surgical group with breast cancer and control group (P value < 0.001). The plasma DNA concentration in stage II, III and IV of breast cancer were higher when compared with healthy group. These tumor size, TNM stage and metastasis were significantly correlated with plasma DNA. The cut point of 120 ng/ml was early screening and treatment follow up breast cancer. 相似文献
19.
K. Thriveni Lakshmi Krishnamoorthy Girija Ramaswamy 《Indian journal of clinical biochemistry : IJCB》2007,22(1):57-60
Carcino Embryonic Antigen (CEA) and Cancer Antigen 15.3 (CA15.3) are the most common tumor markers in breast cancer patients.
Measurement of circulating tumor markers is a non-invasive quantitative method. Serum levels of CEA and CA 15.3 were studied
in female breast cancer patients prior to treatment. To evaluate the utility of these markers, 207 Breast carcinoma patients
belonging to all the stages were considered. Healthy age matched 75 female individuals formed the control group. The serum
levels of CEA and CA 15.3 were analyzed by Enzyme Linked Immunosorbent Assay (ELISA). Results were taken and compared with
stages, tumor size, node and grade. The serum CA 15.3 levels were significant in all the study parameters whereas serum CEA
levels showed no significant changes with any of the parameters. Measurement of serum CA 15.3 levels showed significant correlation
(24.8%) with advanced stages and larger tumor sizes, whereas serum CEA levels did not show any significant correlation in
breast cancer patients prior to treatment. 相似文献
20.
目的 了解TP和CP治疗卵巢癌的效果。方法 回顾性分析我院2000年5月“2005年10月收治的40例卵巢癌病例资料。结果 两组疗效及生存率比较有显著性差异。（P〈0．05）。结论 以TAX为主的联合化疗方案对卵巢癌的疗效较好，尤其是对常规治疗后复发的患者。 相似文献