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1.
Objective: To investigate the structural changes of aorta, and evaluate the effects of atorvastatin on the remodeling of thoracic aorta in spontaneously hypertensive rats (SHR). Methods: Twelve eight-week-old SHR were randomized into atorvastatin treated group (ATV group,n=6) and distilled water group (DW group,n=6); Wistar-Kyoto rats (WKY) were used as normal controls. Atorvastatin was administered to ATV group for 10 weeks by gavage in mixture with distilled water(1 ml); the latter two groups were given the same amount of distilled water by gavage for 10 weeks. Systolic blood pressure of caudal artery was examined before and after treatment, and serum concentrations of total cholesterol, triglycerides and HDL-C were measured. Wall thickness, media thickness, medial cross-sectional area and lumen diameter of thoracic aorta were assessed with computed video processing. Results: Systolic blood pressure in ATV group was markedly lower than that in DW group (P<0.01). Compared with DW group and WKY group, serum concentrations of total cholesterol, triglycerides and HDL-C in ATV group were significantly lower (P<0.01,P<0.05). Wall thickness, media thickness, and medial cross-sectional area to lumen ratio in DW group were significantly higher than those in WKY group and ATV group (P<0.01,P<0.05), but no such difference was found between WKY group and ATV group (P>0.05). Conclusion: Vascular structural changes of aorta are due to the alteration of the vessel wall in early stage of SHR. Atorvastatin can markedly improve vascular remodeling.  相似文献   

2.
目的：研究自发性高血压大鼠（SHR）膈肌功能的变化。方法：大鼠随机分成两组，SHR组和Wistar大鼠组，各8只，应用体外灌流大鼠膈肌条的方法，测量张力一频率曲线，疲劳指数的变化，同时测定膈肌组织中的超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮合酶（NOS）活性（总NOS和iN0s）和NO含量的变化。结果：与对照组相比，SHR组大鼠膈肌张力-频率曲线右移，疲劳指数下降明显（P〈0．01），组织中SOD、总NOS活性和NO含量显著降低（P〈0．01），iNOS、MDA含量显著增加（P＜0．01）。结论：自发性高血压大鼠膈肌功能受到损伤。  相似文献   

3.
对比研究无创尾套法与有创颈总动脉法测量健康大鼠血压的相关性。依次使用尾套法和颈总动脉法测量不同性别和年龄组的健康大鼠收缩压。各组无创血压值均高于有创血压值(P<0.001),两者呈显著直线相关(P<0.01)。清醒动物实验中使用无创血压可以有效,便捷地获取血压参数,减少动物创伤应激。  相似文献   

4.
目的:为探讨糖尿病患者易患动脉粥样硬化是否与结缔组织生长因子有关以及可能的干预药物.方法:建立大鼠糖尿病模型,随机分为正常对照组、糖尿病组、糖尿病盐酸氨基胍治疗组和糖尿病葛根素治疗组.应用逆转录聚合酶链式反应检测各组大鼠主动脉结缔组织生长因子mRNA表达水平.结果发现,糖尿病组大鼠主动脉结缔组织生长因子mRNA明显高于对照组(P＜0.01),葛根素治疗组和氨基胍治疗组结缔组织生长因子mRNA明显低于糖尿病组(P＜0.01),氨基胍治疗组、葛根素治疗组与对照组比较有显著差异(P＜0.05).结果:结缔组织生长因子过多表达与糖尿病患者易患动脉粥样硬化有关.结论:氨基胍、葛根素可降低糖尿病大鼠主动脉结缔组织生长因子mRNA过多表达.  相似文献   

5.
目的:探讨2型糖尿病病人内脏型肥胖和血管并发症的关系.方法:采用CT影像学检查方法对50例2型糖尿病病人进行内脏脂肪测定,根据有无内脏型肥胖将病人分为内脏肥胖组和非内脏肥胖组,观察两组血管并发症危险因子情况(血压、血脂).结果:内脏肥胖组的内脏脂肪平均值为127.12cm,非内脏肥胖组为7O.21cm;内脏肥胖组比非肥胖型组有更高的甘油三酯、血压(P<0.01).结论:内脏脂肪肥胖和心血管危险因子密切相关,是引起2型糖尿病血管并发症的重要危险因素.  相似文献   

6.
目的:探讨辛伐他汀治疗脂肪肝的的临床疗效。方法:120例脂肪肝患者随机分为两组,辛伐他汀治疗组60例采用辛伐他汀20mg,每天1次口服;血脂康治疗组60例采用血脂康600mg,每天2次口服。8周为1个疗程,共3个疗程,观察辛伐他汀治疗组与血脂康治疗组的临床疗效、治疗前后血脂和B超变化情况,另选择同期体检证明为正常的健康者70人作为对照组。结果:辛伐他汀治疗组总有效率(93.1%)与血脂康组(90.3%)相似(P>0.05);辛伐他汀治疗组和血脂康治疗组治疗后与治疗前相比血总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)均明显改善(P<0.01),辛伐他汀治疗组改善优于血脂康组(P<0.05或P<0.01),辛伐他汀治疗组与血脂康治疗组两组治疗后肝功能与治疗前相比均明显改善(P<0.01),但辛伐他汀治疗组与血脂康治疗组两组治疗后相比无显著差异(P>0.05),未见严重不良反应。结论:辛伐他汀是治疗高血脂和脂肪肝的有效药物之一,且副作用少,安全性大,值得临床应用。  相似文献   

7.
目的:探讨心脑血管疾病患者脂蛋白(a)水平及其他脂类的关系,进一步阐明血浆高脂蛋白(a)水平为心脑血管疾病的独立危险因素,支持脂蛋白(a)的检测具有极为重要的意义.方法:采用ELISA法和酶法分别测定心肌梗塞、心绞痛、脑梗死等心脑血管疾病患者及健康对照者的Lp(a)、LDL-C、HDL-C、TG、TC含量.结果:心脑血管疾病患者血浆Lp(a)水平显著高于健康对照组(P＜0.01).血浆脂蛋白(a)水平变化与LDL-C、HDL-C、TG、TC含量无明显相关性.结论:Lp(a)是独立于其他血脂指标的心脑血管疾病的危险因子.  相似文献   

8.
选择体重、产蛋率相近的430日龄健康罗曼褐蛋鸡48只,随机分为2组,每组4个重复,每个重复6只鸡,对照组饲喂基础日粮,试验组在基础日粮中添加1%决明子粉,预试期1周,试验期6周。研究决明子对罗曼褐蛋鸡生产性能、鸡蛋胆固醇含量及血清生化指标的影响。结果表明,日粮中添加1%决明子鸡蛋中的蛋白质、脂肪含量分别比对照组提高10.54%(P0.05)和9.86%(P0.05);每克蛋黄胆固醇含量比对照组降低27.00%(P0.01),每枚鸡蛋胆固醇含量比对照组降低32.85%(P0.01);添加决明子对蛋鸡的生产性能没有显著影响(P0.05),但降低了蛋鸡血清中低密度脂蛋白胆固醇(LDL-C)(P0.01)、总胆固醇(TC)(P0.01)和甘油三酯(TG)(P0.05)的含量,增加了血清高密度脂蛋白胆固醇(HDL-C)(P0.01)的浓度量。说明决明子具有显著降低鸡蛋胆固醇含量,改善鸡蛋品质的作用。  相似文献   

9.
Objective: To assess the effect of angiotensin Ⅱ type 1 (AT1) receptor antagonist losartan on myocardium connexin43 (Cx43) gap junction (GJ) expression in spontaneously hypertensive rats (SHRs) and investigate possible mechanisms. Methods: Sixteen 9-week-old male SHRs and 8 age-matched male Wistar-Kyoto (WKY) rats were included in this study. SHRs were randomly divided into two groups to receive losartan at 30mg/(kg·d) by oral gavage once daily for 8 weeks (SHR-L) or vehicle (0.9% saline) to act as controls (SHR-V); WKY rats receiving vehicle for 8 weeks served as normotensive controls. At the end of the experiment, rats were sacrificed and the hearts were removed. Expressions of Cx43 and nuclear factor-kappaB p65 (NF-κB p65) proteins in all three groups were observed and further investigations on the effect of angiotensin Ⅱ type 1 receptor antagonist losartan (30mg/(kg·d), 8 weeks) on Cx43 expression were conducted with Western blot and immunohistochemistry. NF-κB p65 protein in nuclear extracts was determined by Western blot. Results: Left ventricular (LV) hypertrophy was prominent in SHRs, Cx43 and NF-κB p65 protein expressions were obviously upregulated and Cx43 distribution was dispersed over the cell surface. Treatment with losarton reduced the over-expressions of Cx43 and NF-κB p65 in LV myocardium. The distribution of Cx43 gap junction also became much regular and confined to intercalated disk after losartan treatment. Conclusion: Cx43 level was upregulated in LV myocardium of SHR during early stage of hypertrophy. Angiotensin Ⅱ type l receptor antagonist losartan prevented Cx43 gap junction remodeling in hypertrophied left ventricles, possibly through the NF-κB pathway.  相似文献   

10.
目的:为了研究高血压大鼠左室流出道电位的变化。方法:利用大鼠的离体心脏,采用常规玻璃微电极细胞内记录方法。观察静息电位(RP)、0相去极幅度(APA)、0相最大除极速度(Vmax)、复极时程(APD)以及复极50％(APD_(50))和复极90％(APD_(90))的时间。结果:高血压大鼠左室流出道诱发电位APD、APD_(50)、APD_(90)都明显高于正常同龄大鼠(P<0.01)。结论:高血压大鼠左室流出道动作电位复极时程延长。  相似文献   

11.
This study was aimed to investigate the level of sEGF in CAG with different therapies of either Chinese traditional medicine or western medicine. Patients were divided into spleen-reinforcingⅠ, spleen-reinforcing Ⅱ,dampness-resolving and western medicine group by Differentiation Syndrome. Healthy volunteers acted as controls. The sEGF was investigated before and after treatment. The level of sEGF in CAG was higher than that in control group(P<0.01). In patients of spleen-reinforcingⅠgroup and spleen-reinforcing Ⅱgroup, the symptoms and pathological manifestations were improved dramatically (P<0.01) and sEGF dropped markedly after treatment(P<0.01 and P<0.05).The level of sEGF in the dampness-resolving group increased after treatment (P<0.05). But the level of sEGF in the western-medicine group dropped a little after treatment (P>0.05). The inflammation of gastric mucosa may cause the elevation of sEGF in CAG reflectively. After being effectively treated with Chinese traditional medicine, the symptoms of CAG improved simultaneously with the return of sEGF. SEGF is a sensitive index to prognosis of CAG.  相似文献   

12.
目的：探讨土茯苓中药复方制剂和大蒜油的排铅效果,为铅中毒的防治提供一定的理论依据。方法：以40mg／L的醋酸铅溶液,按0．01mug体重剂量连续15d灌胃造模,造模成功后将48只雄性成年小鼠随机分成4组,即土茯苓中药复方制剂组、大蒜油组、乙二胺四乙酸组和中毒不治疗组,连续15d驱铅治疗。在造模前、第16天、第31天分别测定各组小鼠的体重及抽取小鼠尾部全血并用石墨炉原子吸收法直接测定小鼠的血铅含量,对实验结果进行统计学分析。结果：①血铅含量：统计学意义驱铅治疗后,土茯苓中药复方制剂组、大蒜油组、乙二胺四乙酸组分别与中毒不治疗组的血铅含量比较,差异均有统计学意义（P〈0．01）;土茯苓中药复方制剂组、大蒜油组、乙二胺四乙酸组的血铅含量两两比较,差异有统计学意义（P〈0．01）。驱铅治疗后各组的血铅含量为：土茯苓中药复方制剂组〈EDTA组〈大蒜油组〈中毒不治疗组。（参体重：土茯苓中药复方制剂组、大蒜油组分别与中毒不治疗组的体重比较,差异有统计学意义（P〈0．05）;土茯苓中药复方制剂组与大蒜油组的体重比较,差异有统计学意义（P〈0．05）。土茯苓中药复方制剂组的体重〉大蒜油组的体重。③存活率：土茯苓中药复方制剂组、大蒜油组分别与中毒不治疗组的存活率比较,差异有统计学意义（P〈0．01）;土茯苓中药复方制剂组与大蒜油组的存活率比较,差异无统计学意义（P〉O．05）。结论：土茯苓中药复方制剂、大蒜油对血铅均有促排作用;驱铅功效为：土茯苓中药复方制剂〉大蒜油。  相似文献   

13.
目的:观察中药"病毒克"颗粒剂对人工感染鸡新城疫病防治的肝功指标的影响.方法:试验用75只1日龄罗曼鸡人工感染NDV后,分每千克体重给"病毒克"颗粒剂0.5g、1g治疗组和0.5g预防组,并设阳性对照组和健康对照组,测定各组肝功能指标.结果:血清总蛋白(TP)0.5 g治疗组极显著高于阳性对照组(P＜0.01);白蛋白各治疗组极显著高于阳性对照组,预防组显著高于阳性对照组;r-谷氨酰转移酶(GGT)和胆固醇(CHO)阳性对照组显著低于治疗组;乳酸脱氢酶(HDBH)阳性对照组显著高于各治疗组和预防组等.结论:中药"病毒克"颗粒剂对肝功能有较好的保护作用.  相似文献   

14.
用免疫组织化学PAP法观察33例人阑尾肌层生长抑素(SS)样免疫反应(-IR)神经。阑尾炎组25例(单纯组7例,慢性组6例,化脓组7例,坏疽组5例);对照组8例。结果:各组阑尾肌层中均有SS-IR神经分布,环肌层较多,各阑尾炎组SS-IR神经丛及神经细胞数密度均较对照组减少(P<0.05,P<0.01),坏疽组SS-IR神经丛数密度较单纯组、慢性组减少(P<0.05)。本文结果提示:阑尾肌层SS-IR神经参与了阑尾炎的神经调理。  相似文献   

15.
目的:观察护肝醒脾汤治疗酒精性脂肪肝的疗效。方法:将72例酒精性脂肪肝患者随机分为两组,治疗组服用护肝醒脾汤,对照组口服硫普罗宁片治疗,比较两组疗效及肝功能、血脂变化。结果:治疗组总有效率88.89%,对照组总有效率58.33%,两组比较有显著性差异(P<0.01)。治疗组肝功能、血脂治疗后较治疗前显著改善(P<0.01),并优于对照组。结论:护肝醒脾汤对酒精性脂肪肝有良好的治疗作用。  相似文献   

16.
Study on the neurotoxic effects of low-level lead exposure in rats   总被引：10，自引：0，他引：10  
Objective: To investigate effects of developmental lead exposure on nitric oxide synthase (NOS) activity in different brain regions and on N-methyl-D-aspartate (NMDA) receptor mRNA expression in the hippocampus of rats. On the basis of these observations, we explored possible mechanisms by which lead exposure leads to impaired learning and memorizing abilities in children. Methods: A series of rat animal models exposed to low levels of lead during the developing period was established (drinking water containing 0.025%, 0.05% and 0.075% lead acetate). NOS activities in the hippocampus, the cerebral cortex, the cerebellum and the brain stem were determined with fluorescence measurement and levels of mRNA expression of the NMDA receptor 2A (NR2A) subunit and NMDA receptor 2B (NR2B) subunit in the rat hippocampus were measured with Retro-translation (RT-PCR). Results: There were no differences in the body weight of rat pups between any of the groups at any given time (P>0.05). The blood lead level of Pb-exposed rat pups showed a systematic pattern of change: at 14 d of age, it was lower than that at 7 d of age, then rising to the peak level at 21 d and finally falling to lower levels at 28 d. The hippocampal NOS activities of lead-exposed groups were all lower than that of the control group on the 21st and 28th day (P<0.01). NOS activities in the cerebellum of lead-exposed groups were all lower than that of the control group on the 21st and 28th day (P<0.001) and the NOS activity of the 0.025% group was significantly lower than that of the 0.05% and 0.075% groups on the 28th day (P<0.05). NOS activity in the cerebral cortex of the 0.075% group was significantly lower than that of the control, 0.025% and 0.05% groups on the four day spans (P<0.001). There was no significant difference of NOS activity in the brain stem between any lead-exposed group and the control group on the four day spans. In the 0.05% and the 0.075% groups, the level of NR2A mRNA expression was higher than that in the control group at 7 d and 14 d of age (P<0.05). In the 0.025% group, the level of NR2A was found to be higher than that in the control group at 7 d of age only (P<0.05). No significant differences were found for the levels of NR2B mRNA expression between any of the groups at any given time. Conclusions: NOS activity in the hippocampus, the cerebral cortex and the cerebellum are inhibited by lead exposure. The degree of the inhibitory effect depends on the time span of exposure and the lead concentration. Developmental low-level lead exposure was found to raise the level of NR2A mRNA expression in the hippocampus of rats. Developmental low-level lead exposure does not affect the level of NR2B mRNA expression in the hippocampus.  相似文献   

17.
Objective:Atherosclerotic plaques and neovascularization play an important role in the course of coronary atherosclerosis.This study evaluated the effect of recombinant endostatin on experimental atherosclerotic plaques and neovascularization in rabbits.Methods:Eighteen healthy male rabbits were divided into three groups:control group,atherosclerotic model group,and recombinant endostatin treated group.The atherosclerotic model was established via a high-cholesterol diet after balloon catheter injury.The subject weights,serum total cholesterol,creatine kinase-myocardial band fraction(CKMB),and matrix metalloproteinase-2(MMP-2)were measured.Six weeks after treatment,the aortic roots were taken for pathological assay.The thickness ratio of the intima to media was measured by hematoxylin and eosin(HE)staining,and the number of neovessels was measured by immunohistochemistry via monoclonal antibody CD31 staining.Results:The weight,plasma total cholesterol,and CKMB were not significantly different between the atherosclerotic model group and the recombinant endostatin treated group,but much higher than those of the control group(P<0.05).The thickness ratio of the intima to media in the recombinant endostatin treated group was distinctly less than that in the atherosclerotic model group(P<0.05).The number of neovessels decreased dramatically(P<0.05)and the content of MMP-2 decreased slightly without statistical difference(P>0.05)in the recombinant endostatin treated group,compared to the atherosclerotic model group.Conclusions:Recombinant endostatin is able to inhibit the growth of neovascularization in the atherosclerotic plaque and the development of plaque.  相似文献   

18.
目的研究不同年龄自发性高血压大鼠血管平滑肌Ca2+/CaM-PP活性变化.方法应用酶活性测定方法,对12周、16周SHR大鼠和Wistar大鼠的A、MA、CA血管平滑肌Ca2+/CaM-PP进行活性比较.结果Wistar大鼠随年龄增长,Ca2+/CaM-PP活性呈上升趋势,而SHR鼠其阻力血管该酶活性降低,但随年龄变化不明显.结论①自发性高血压使阻力血管平滑肌Ca2+/CaM-PP下降,但12周与16周间无显著差异.②不同种鼠血管平滑肌该酶活性变化不同.  相似文献   

19.
Objective:The aim of this study is to investigate if dual-source computed tomography(DSCT) could guide the percutaneous coronary intervention(PCI) of chronic total occlusion(CTO).Methods:We enrolled patients who were confirmed to have at least one native coronary artery CTO by DSCT before they underwent selective PCI in the period from December 2007 to October 2008.A CTO was defined as an obstruction of a native coronary artery with no luminal continuity.The CT-guided PCI procedure involved placing CT and fluoroscopic images side-by-side on the screen.DSCT images were analyzed for location,segment,plaque characteristics,calcification,and proximal lumen diameter of the CTO before PCI.The guidewire was advanced and manipulated under CT guidance.The PCI was carried out and the results were compared.Results:Seventy-four CTOs were assessed.PCI was successful in 57 cases of CTOs(77.0%).According to the results,CTOs were divided into two groups:successful-PCI and failed-PCI.All coronary artery paths of CTOs were clearly recognized by DSCT.In the successful-PCI group,soft plaques were detected much more often than those in the failed-PCI group,but fibrous and calcified plaques were seen more often in the failed-PCI group.Calcification severity in CTO segments showed a significant difference between the groups(P=0.014).Calcified plaques were detected in 20(35.1%) lesions in the successful-PCI group.More than 70% of the failures were calcified plaques,of which there were two arc-calcified and one circular-calcified lesions.Occlusions were longer in the failed-PCI group than those in the successful-PCI group [(38.8±25.0) vs.(18.0±15.3) mm,respectively,P0.01].Fewer guidewires were used in the successful-PCI group compared with the failed-PCI group(1.7±1.0 vs.2.5±0.9,respectively,P0.01).The logistic regression analysis indicated that predictors of recanalization of CTOs included occlusion length(P=0.0035,risk ratio(RR)=0.93) and calcification severity(P=0.05,RR=0.27).Multi-linear trends analysis showed that the factors affecting procedural time were CTO location(P=0.0141) and occlusion length(P=0.0035).Conclusions:DSCT could delineate the path of CTOs and characterize plaques.The outcomes of PCI were related to thrombolysis in myocardial infarction(TIMI) flow grade,CTO characteristics,severity of calcified plaques,and the length of occlusive segments.Occlusion length and calcification severity were independent predictors of CTOs.Occlusion length and CTO segments could also help to estimate the duration of interventional procedures.  相似文献   

20.
INTRODUCTION Bronchioloalveolar carcinoma (BAC) is a par-ticular subtype of pulmonary adenocarcinoma de-rived from clara cell and type II pneumocyte. BAC cells grow along and within alveolar spaces while the alveolar framework of the lung is preserved. The incidence of BAC appears to be rising recently. The etiology and pathogenesis of this unique neoplastic disease are still unclear; many studies of oncogene and tumor suppressor gene expression include BAC with all adenocarcinoma o…  相似文献   

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