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1.
Physical inactivity is a major contributor to low-grade systemic inflammation. Most of the studies characterizing interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) release from exercising legs have been done in young, healthy men, but studies on inactivity in older people are lacking. The impact of 14 days of one-leg immobilization (IM) on IL-6 and TNF-α release during exercise in comparison to the contralateral control (CON) leg was investigated. Fifteen healthy men (age 68.1?±?1.1?year (mean?±?SEM); BMI 27.0?±?0.4 kg·m2; VO2max 33.3?±?1.6 ml·kg?1·min?1) performed 45?min of two-leg dynamic knee extensor exercise at 19.5?±?0.9 W. Arterial and femoral venous blood samples from the CON and the IM legs were collected every 15?min during exercise, and thigh blood flow was measured with ultrasound Doppler. Arterial plasma IL-6 concentration increased with exercise (rest vs. 45?min, main effect p?p?p?=?.085, effect size 0.28) higher in the IM leg compared to the CON leg (288 (95% CI: 213–373) vs. 220 (95% CI: 152–299) pg·min?1, respectively). There was no release of TNF-α in either leg and arterial concentrations remained unchanged during exercise (p?>?.05). In conclusion, exercise induces more pronounced IL-6 secretion in healthy older men. Two weeks of unilateral immobilization on the other hand had only a minor influence on IL-6 release. Neither immobilization nor exercise had an effect on TNF-α release across the working legs in older men.  相似文献   

2.
The effectiveness of a nap as a recovery strategy for endurance exercise is unknown and therefore the present study investigated the effect of napping on endurance exercise performance. Eleven trained male runners completed this randomised crossover study. On two occasions, runners completed treadmill running for 30?min at 75% ?O2max in the morning, returning that evening to run for 20?min at 60% ?O2max, and then to exhaustion at 90% ?O2max. On one trial, runners had an afternoon nap approximately 90?min before the evening exercise (NAP) whilst on the other, runners did not (CON). All runners napped (20?±?10?min), but time to exhaustion (TTE) was not improved in all runners (NAP 596?±?148?s vs. CON 589?±?216?s, P?=?.83). Runners that improved TTE after the nap slept less at night than those that did not improve TTE (night-time sleep 6.4?±?0.7?h vs. 7.5?±?0.4?h, P?r2 ? =??0.76, P?=?.001). In runners that improved TTE, ratings of perceived exertion (RPE) were lower during the TTE on NAP than CON compared to runners that did not improve (?0.4?±?0.6 vs. 0?±?0, P?=?.05). Reduced exercising sense of effort (RPE) may account for the improved TTE after the nap. In conclusion, a short afternoon nap improves endurance performance in runners that obtain less than 7?h night-time sleep.  相似文献   

3.
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4.
In recent years, prevalence of obesity in children and adolescents has increased. A strategy for prevention and management of obesity is aerobic training (AT) due to its effectiveness to decrease fat mass. AT increases the content of SIRT3, a mitochondrial protein that increases the expression of PGC-1α and NFR1, thereby enhances mitochondrial function and metabolic health. Resistance training (RT) provides metabolic benefits but its effect on SIRT3 content is unknown. To compare the effect of AT and RT on SIRT3, PGC-1α and NRF-1 protein levels in skeletal muscle of sedentary obese adolescents. Twenty-seven sedentary obese male adolescents (age: 16.7?±?0.9 years; BMI: 33.7?±?4.3?kg/m2) completed a 1-month control period prior to randomization to one of two supervised exercise protocols: AT (3 days/week, 40 min/day, 70–80% peak heart rate) or RT (3 days/week, 11 exercises, 2 sets/exercise, 12 repetitions/set) for 12 weeks. Biopsies were obtained from the vastus lateralis muscle before and after 12 weeks to analyse SIRT3, PGC-1α and NRF-1 proteins content. Peak oxygen consumption (VO2peak) and anthropometric variables were evaluated before and after training. AT increased SIRT3 content, which was associated with improvements in PGC-1α content and body fat percentage. RT did not affect SIRT3 or PGC-1α. VO2peak increased only in AT. The increase in muscle mitochondrial SIRT3 was observed only following AT. In contrast, RT increased muscle mass without improving SIRT3 in obese male adolescents.  相似文献   

5.
Many physically active individuals have undertaken intermittent fasting to reduce their daily caloric intake. However, abstaining from meals for a specific length of time may lead to the acute disturbance of highly carbohydrate-dependent exercise performance. The purpose of this study was to observe the effect of 10 days of intermittent fasting on high-intensity type exercises, Wingate anaerobic (WT) and prolonged high-intensity time-to-exhaustion (HIT) cycling test. Twenty participants were randomised into an intermittent fasting (FAS) and a control group (CON). One day after baseline data collection on Day-0 where participants consumed their recommended daily caloric intake (FAS?=?2500?±?143?kcal?day?1; CON?=?2492?±?20?kcal?day?1) served over a course of five meals, the FAS group consumed only four meals where 40% was restricted by the omission of lunch (FAS?=?1500?±?55?kcal?day?1). This diet was then continued for 10 days. Data on exercise performance and other dependent variables were collected on Day-2, -4, -6, -8 and -10. A reduction in WT power in the FAS group was observed on Day-2 (821.74?±?66.07?W) compared to Day-0 (847.63?±?95.94?W) with a moderate effect size (p?p?p?相似文献   

6.
Mouth rinsing using a carbohydrate (CHO) solution has been suggested to improve physical performance in fasting participants. This study examined the effects of CHO mouth rinsing during Ramadan fasting on running time to exhaustion and on peak treadmill speed (Vpeak). In a counterbalanced crossover design, 18 sub-elite male runners (Age: 21?±?2 years, Weight: 68.1?±?5.7?kg, VO2max: 55.4?±?4.8?ml/kg/min) who observed Ramadan completed a familiarization trial and three experimental trials. The three trials included rinsing and expectorating a 25?mL bolus of either a 7.5% sucrose solution (CHO), a flavour and taste matched placebo solution (PLA) for 10?s, or no rinse (CON). The treatments were performed prior to an incremental treadmill test to exhaustion. Three-day dietary and exercise records were obtained on two occasions and analysed. Anthropometric characteristics were obtained and recorded for all participants. A main effect for mouth rinse on peak velocity (Vpeak) (CHO: 17.6?±?1.5?km/h; PLA: 17.1?±?1.4?km/h; CON: 16.7?±?1.2?km/h; P?ηp2?=?0.49) and time to exhaustion (CHO: 1282.0?±?121.3?s; PLA: 1258.1?±?113.4?s; CON: 1228.7?±?98.5?s; P?=?.002, ηp2?=?0.41) was detected, with CHO significantly higher than PLA (P?P?P?>?.05). Energy availability from dietary analysis, body weight, and fat-free mass did not change during the last two weeks of Ramadan (P?>?.05). This study concludes that carbohydrate mouth rinsing improves running time to exhaustion and peak treadmill speed under Ramadan fasting conditions.  相似文献   

7.
Abstract

Post exercise hypotension (PEH) is primarily attributed to post-exercise vasodilation via central and peripheral mechanisms. However, the specific contribution of metabolic cost during exercise, independent of force production, is less clear. This study aimed to use isolated concentric and eccentric exercise to examine the role of metabolic activity in eliciting PEH, independent of total work. Twelve participants (6 male) completed upper and lower body concentric (CONC), eccentric (ECC), and traditional (TRAD) exercise sessions matched for work (3?×?10 in TRAD and 3?×?20 in CONC and ECC; all at 65% 1RM). Blood pressure was collected at baseline and every 15?min after exercise for 120?min. Brachial blood flow and vascular conductance were also assessed at baseline, immediately after exercise, and every 30?min after exercise. ?O2 was lower during ECC compared to CONC and TRAD (?2.7?mL/Kg/min?±?0.4 and ?2.2?mL/Kg/min?±?0.4, respectively p?<?0.001). CONC augmented the PEH response (Peak ΔMAP ?3.3?mmHg?±?0.9 [mean?±?SE], p?=?0.006) through 75?min of recovery and ECC elicited a post-exercise hypertensive response through 120?min of recovery (Peak ΔMAP +4.5?mmHg?±?0.8, p?<?0.001). CONC and TRAD elicited greater increases in brachial blood flow post exercise than ECC (Peak Δ brachial flow +190.4?mL/min?±?32.3, +202.3?mL/min?±?39.2, and 69.6?mL/min?±?19.8, respectively, p?≤?0.005), while conductance increased immediately post exercise in all conditions and then decreased throughout recovery following ECC (?32.9?mL/min/mmHg?±?9.3, p?=?0.005). These data suggest that more metabolically demanding concentric exercise augments PEH compared to work-matched eccentric exercise.  相似文献   

8.
This investigation examined the oxidative stress (F2-Isoprostane; F2-IsoP) and inflammatory (interleukin-6; IL-6) responses to repeat-sprint training in hypoxia (RSH). Ten trained male team sport athletes performed 3(sets)*9(repetitions)*5?s cycling sprints in simulated altitude (3000?m) and sea-level conditions. Mean and peak sprint power output (MPO and PPO) were recorded, and blood samples were collected pre-exercise, and again at 8 and 60?min post-exercise. Both MPO and PPO were significantly reduced in hypoxia (compared to sea-level) in the second (MPO: 855?±?89 vs. 739?±?95?W, p?=?.006; PPO: 1024?±?114 vs. 895?±?112?W, p?=?.010) and third (MPO: 819?±?105 vs. 686?±?83?W, p?=?.008; PPO: 985?±?125 vs. 834?±?99?W, p?=?.008) sets, respectively. IL-6 was significantly increased from pre- to 1?h post-exercise in both hypoxia (0.7?±?0.2 vs. 2.4?±?1.4?pg/mL, p?=?.004) and sea-level conditions (0.7?±?0.2 vs. 1.6?±?0.3?pg/mL, p?d?=?0.80) suggesting higher IL-6 levels of post-hypoxia. F2-IsoP was significantly lower 1?h post-exercise in both the hypoxic (p?=?.005) and sea-level (p?=?.002) conditions, with no differences between trials. While hypoxia can impact on exercise intensity and may result in greater post-exercise inflammation, it appears to have little effect on oxidative stress. These results indicate that team sport organisations with ready access to hypoxic training facilities could confidently administer RSH without significantly increasing the post-exercise inflammatory or oxidative stress response.  相似文献   

9.
VO2 fluctuations are argued to be an important mechanism underpinning chronic adaptations following interval training. We compared the effect of exercise modality, continuous vs. intermittent realized at a same intensity, on electrical muscular activity, muscular oxygenation and on whole body oxygen uptake. Twelve participants (24?±?5 years; VO2peak: 43?±?6?mL·?min?1·kg?1) performed (i) an incremental test to exhaustion to determine peak work rate (WRpeak); two randomized isocaloric exercises at 70%WRpeak; (ii) 1 bout of 30 min; (iii) 30 bouts of 1?min work intercepted with 1?min passive recovery. For electromyography, only the CON exercise showed change for the vastus lateralis root-mean-square (+6.4?±?5.1%, P?P?vs. 2.32?±?1.21?mM, respectively, for the CON and INT, P?vs. 356?±?301?sec, respectively, for the CON and INT, P?相似文献   

10.
目的:研究运动后不同时间大鼠骨骼肌CaMKⅡ磷酸化水平及核内PGC-1、HDAC5蛋白含量的变化,以探讨运动后PGC -1α基因表达时相性变化的调节机制.方法:9周龄的雄性Wistar大鼠(167±4) g48只,随机分成安静对照组(C)和跑台运动后0h、3h、6h、12 h、24h取材组,共6组,每组8只.大鼠进行0坡度的1h跑台运动,跑台速度34 m/min.Western blot法测定蛋白含量及磷酸化水平,RT-PCR法测定基因表达.结果:PGC-1α mRNA含量,运动后即刻变化不显著,运动后3h、6h显著增加,12h虽仍高于对照组,但与6h相比显著降低,24h恢复至安静水平.核内PGC-1 α蛋白含量运动后各取材点均无显著变化.核内HDAC5蛋白含量则在运动后3h、6h下降显著,12h虽仍低于对照组,但与6h相比显著增加,24 h恢复到安静组水平.CaMKⅡ磷酸化水平,运动后0h,3h显著升高,6h虽仍高于对照组,但与3h相比显著降低,12h恢复至安静水平.结论:运动后PGC-1α基因表达的时相性变化可能是由对应时相变化规律的CaMKⅡ通过调节核内HDAC5含量,解除了转录因子对PGC-1α基因转录的抑制而实现.  相似文献   

11.
The protective action of remote ischaemic preconditioning (RIPC) has been demonstrated in the context of surgical interventions in cardiology. Application of RIPC to sports performance has been proposed, but its effect on the electrocardiogram (ECG) during exercise remains unknown. This exploratory study aims to measure the changes in ventricular repolarization observed during exercise following RIPC in healthy subjects. In an experimental randomized crossover study, 17 subjects underwent two bouts of constant load exercise tests at 75% and 115% of gas exchange threshold (GET). Prior to exercise, they were allocated to either control or RIPC intervention with four cycles of 5?min of ischaemia followed by 5?min of reperfusion. ECG was continuously recorded during the protocol. QT and RR intervals were measured every 30?s (on an average tracing of the preceding 10?s). Although the time course of RR intervals did not differ between the two interventions (p?=?.56 at 75% GET and p?=?.74 at 115% GET), a significant shortening of QT intervals (measured from Q onset to T end) was observed during exercise (mean?±?standard deviation of RIPC vs. control: ?32?±?19?ms at 75% GET (p?p?p?p?相似文献   

12.
Objectives: This study was designed to investigate the association of gender, fibre type composition, and anaerobic performance with the basal skeletal muscle signalling cascades regulating muscle phenotype. Design: Muscle biopsies were obtained from 25 men and 10 women all young and healthy. Methods. Protein phosphorylation of Thr172AMPKα, Ser221ACCβ, Thr286CaMKII as well as total protein abundance of PGC-1α, SIRT1, and CnA were measured by Western blot and anaerobic performance by the Wingate test. Results: Percent type I myosin heavy chain (MHC I) was lower in men (37.1?±?10.4 vs. 58.5?±?12.5, P?P?P?221ACCβ and Thr286CaMKII fractional phosphorylation tended to be higher in men (P?=?.1). PGC1-α and SIRT1 total protein expression was similar in men and women, whereas CnA tended to be higher in men (P?=?.1). Basal AMPKα phosphorylation was linearly related to the percentage of MHC I in men (r?=?0.56; P?Conclusion: In summary, skeletal muscle basal AMPKα phosphorylation is higher in men compared to women, with no apparent effect on anaerobic performance.  相似文献   

13.
The aim of this study was to compare the impact of continuous (CON) and intermittent (INT) heat acclimation protocols on repeat-sprint performance, and to also assess the degree of performance decay following acclimation. Using a pair-matched, between subjects design, 16 trained male team sport athletes were allocated to either INT (8 sessions over 15 days) or CON acclimation (8 sessions over 8 days) groups. Participants performed a heat tolerance test (HTT) involving 60-min of repeat-sprint cycling with a 10-min half time break (in 35.3?±?0.7°C, 60.1?±?4.0%; RH) two days pre- (pre-HTT) and post-acclimation (post-HTT1). Decay was investigated with two further HTT's completed over the next two weeks (post-HTT2 and post-HTT3). Results showed the post-HTT1 performance variables [mean power (pre-HTT; INT?=?1002.07?±?173.74, CON?=?1057.10?±?180.07 / post-HTT1; INT?=?1097.11?±?186.85, CON?=?1163.77?±?184.65 W), mean power (W.kg?1), total work (kJ) and work (J.kg?1)] were greater than pre-HHT (p?p?相似文献   

14.
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15.
Aims: Exercise combined with adipose tissue lipolytic inhibition augments intramuscular lipid and glycogen use in type 2 diabetes patients. The present study investigates the impact of adipose tissue lipolytic inhibition during exercise on subsequent postprandial glycemic control in type 2 diabetes patients.

Methods: Fourteen male type 2 diabetes patients (age 65?±?2 years, HbA1c 6.7?±?0.1% (50?±?2?mmol/mol)) participated in a double-blind placebo-controlled randomized cross-over study in which subjects performed endurance-type exercise after being administered 250?mg of a nicotinic acid analogue (acipimox; ACP) or a placebo (PLA). A control experiment was included in which no exercise was performed (CON).

Results: Sixty minutes of endurance-type exercise (at 45% Wpeak) did not significantly lower circulating plasma glucose and insulin excursions in PLA when compared with CON (P?=?.300). Acipimox administration strongly reduced circulating plasma FFA concentrations during exercise (P?i.e. postprandial) in ACP when compared with either CON (P?=?.041 and P?=?.002, respectively) or PLA (P?=?.009 and P?=?.001, respectively).

Conclusions: Collectively, exercise with adipose tissue lipolytic inhibition reduces postprandial blood glucose and insulin excursions and, as such, further improves glycemic control in male type 2 diabetes patients.  相似文献   

16.
ABSTRACT

Purpose: The purpose of this study was to identify whether post-resistance exercise (REx) blood flow restriction (BFR) can elicit a similar acute training stimulus to that offered by either heavy REx or traditional low-load BFR REx. Method: Ten men completed trials with 30% one-repetition maximum (1RM) for 5 sets of 15 repetitions without BFR (30%), with BFR during exercise (30% RD), and with postexercise BFR (30% RP) and at 75% 1RM for 3 sets of 10 repetitions. Lactate and cortisol were measured before and up to 60 min after exercise. Thigh circumference, ratings of perceived exertion (RPE), and pain were measured before and after exercise. Surface electromyography was measured during exercise. Results: All conditions had a large effect (effect size [ES] > 0.8) on lactate, with the largest effects observed with the 75% condition; no differences were observed between the 30% conditions. All conditions had a moderate effect (ES > 0.25 ≤ 0.4) on increasing thigh circumference. This effect was maintained (ES = 0.35) with the application of BFR after REx (30% RP). Change in RPE, from the first to last set, was significantly greater with 30% RD compared with other conditions (all p < .05). Electromyography amplitude was higher and percentage change was greater for the 75% condition compared with the other conditions (both p < .05). Conclusions: The application of BFR immediately post-REx altered several of the responses associated with REx that is aimed at inducing muscular hypertrophy. Additionally, these changes occurred with less pain and perceived exertion suggesting that this form of REx may offer an alternative, tolerable method of REx.  相似文献   

17.
The potential effect of fatigue on stroke production in tennis players is still controversial. The aim of this study was to analyse the tennis serve speed and accuracy in prolonged male professional matches played on grass courts. We analysed tennis serve statistics from five-set Wimbledon matches (n?=?15; 30 players). Results showed that match duration averaged 208.3?±?28.3?min. The overall serve speed was 177.0?±?10.2?km/h in the first set and 176.1?±?11.7?km/h in the fifth set (p?=?.34). The difference of all accuracy values of first set serves was not significantly different from those of the fifth set: percentage of valid first serves, 63.1?±?11.1% vs. 62.3?±?11.8%, respectively (p?=?.78); percentage of “aces”, 11.2?±?9.1% vs. 10.0?±?8.9%, respectively (p?=?.39); percentage of “winners”, 2.6?±?7.6% vs. 1.2?±?2.2%, respectively (p?=?.36); percentage of “double faults”, 2.8?±?3.0% vs. 2.8?±?3.4% (p?=?.97). In conclusion, tennis players were able to maintain constant serve speed and accuracy over five-set matches played on grass courts. Professional tennis players are capable of overcoming fatigue and/or make movement adjustments to effectively perform complex technical strokes like the serve throughout matches played on grass courts lasting more than 3?h in average.  相似文献   

18.
Abstract

The purpose of this study was to examine the effect of fatiguing exercise on sex-related differences in the function of hamstring and quadriceps muscles at several angular velocities and joint angles. Physically active participants (50 male: 28.7?±?4.5y, 1.82?±?0.07 m, 82.3?±?6.87?kg; 50 female: 27.0?±?5.8y, 1.61?±?0.08 m, 68.75?±?9.24?kg) carried out an isokinetic assessment to determine concentric and eccentric torques during knee extension and flexion actions at three different angular velocities (60/180/300°/s). The H/QFUNCT was calculated using peak torque (PT) values at 3 different joint-angle-specific (15°, 30° and 45° of knee flexion). A repeated measures analysis of variance (ANOVA) was used to compare within group results. Between group comparisons of sex-related differences were assessed by independent T-tests. Fatiguing exercise in males resulted in a decrease in H/QFUNCT ratios for each angle of knee flexion at both 60°/s and 300°/s angular velocities (p?<?0.05). In females, significant decreases in H/QFUNCT ratios were observed following fatiguing exercise for each angle of knee flexion and angular velocity (p?<?0.01). Significant differences in H/QFUNCT ratios following fatiguing exercise were evident between males and females at each joint angle and angular velocity (p?<?0.01). These findings indicate sex related differences in H/QFUNCT ratios following fatiguing exercise. Females have greater reductions in torque and H/QFUNCT ratios following fatigue than their male counterparts. This potentially exposes females to higher risks of injury, particularly when fatigued. Practitioners should attend to the imbalance in fatigue resistance of hamstring and quadriceps function, particularly in female athletes.  相似文献   

19.
ABSTRACT

This study examined the effects of lower-body compression garments on perceived recovery and subsequent performance in basketball athletes. In a parallel-group design, 30 recreational, male basketball athletes were randomly allocated to either a control (CON, n = 15, loose-fitting clothing) or experimental group (COMP, n = 15, compression garments) for 15 h following fatigue-inducing, basketball-specific exercise in the evening (1600-1800 h). Perceptual measures of fatigue and muscle soreness, as well as physical performance tests (sprints, jumps and agility), were performed pre-exercise, post-exercise, and post-recovery (15 h following exercise). Subjective and objective measures of sleep were recorded following the exercise trial. There were non-significant (p > 0.05), unclear-trivial differences between groups for all performance measures. Perceived post-recovery fatigue (d = ?1.27, large) and muscle soreness (d = ?1.61, large) were significantly lower in COMP compared to CON (p < 0.05). COMP exhibited better perceived sleep quality (d = 0.42, small, p = 0.18) than CON, with an unclear difference in sleep duration between groups (p > 0.05). Wearing lower-body compression garments overnight improved perceived fatigue and muscle soreness, but had negligible effects on subsequent physical performance in basketball athletes. Future research should focus on longer periods of compression wear following fatiguing exercise.  相似文献   

20.
The aim of this study was to compare the effect of low-load resistance exercise (LLRE) with continuous and intermittent blood flow restriction (BFR) on the creatine kinase (CK), lactate dehydrogenase (LDH), protein carbonyl (PC), thiobarbituric acid-reactive substance (TBARS) and uric acid (UA) levels in military men. The study included 10 recreationally trained men aged 19 ± 0.82 years who underwent the following experimental protocols in random order on separate days (72–96 h): 4 LLRE sessions at a 20% 1RM (one-repetition maximum [1RM]) with continuous BFR (LLRE + CBFR); 4 LLRE sessions at 20% 1RM with intermittent BFR (LLRE + IBFR) and 4 high-intensity resistance exercise (HIRE) sessions at 80% 1RM. The CK and LDH (markers of muscle damage) levels were measured before exercise (BE), 24 h post-exercise and 48 h post-exercise, and the PC, TBARS and UA (markers of oxidative stress) levels were measured BE and immediately after each exercise session. There was a significant increase in CK in the HIRE 24 post-exercise samples compared with the LLRE + CBFR and LLRE + IBFR (P = 0.035, P = 0.036, respectively), as well as between HIRE 48 post-exercise and LLRE + CBFR (P = 0.049). Additionally, there was a significant increase in CK in the LLRE + CBFR samples BE and immediately after each exercise (Δ = 21.9%) and in the HIRE samples BE and immediately after each exercise, BE and 24 post-exercise, and BE and 48 post-exercise (Δ values of 35%, 177.6%, and 177.6%, respectively). However, there were no significant changes in LDH, PC, TBARS, and UA between the protocols (P > 0.05). Therefore, a physical exercise session with continuous or intermittent BFR did not promote muscle damage; moreover, neither protocol seemed to affect the oxidative stress markers.  相似文献   

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