Education and community development: The quest for national unity in Malaysia     

Ibrahim Saad 《International Journal of Educational Development》1982,2(3):249-255

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Antineoplastic activity in L-Asparaginase of Cladosporium cladosporiodies     

S. S. Ali  V. Rai  K. Soni  P. Kulshrestha  S. K. Lal 《Indian journal of clinical biochemistry : IJCB》1993,8(1):68-70

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Application of real options analysis for pharmaceutical R&D project valuation—Empirical results from a survey     

Marcus Hartmann  Ali Hassan 《Research Policy》2006,35(3):343-354

Real options analysis was often recommended as an emerging valuation technique for high-risk investment projects. Former inter-sectoral surveys have drawn an ambivalent picture of real options usage in general. In addition, there is a lack of sector-specific investigations. In the following article the results of an in-depth analysis of collected empirical data regarding the application of this new tool in the pharmaceutical sector is presented by capturing the internal view from the pharmaceutical companies themselves and the external view from the health care departments of financial service firms. R&D stage specific modi of application, reasons for reluctance in the employment of real options and their assumed future prospects are elucidated.  相似文献   

Service learning in higher education: a systematic literature review     

Salam  Maimoona  Awang Iskandar  Dayang Nurfatimah  Ibrahim  Dayang Hanani Abang  Farooq  Muhammad Shoaib 《Asia Pacific Education Review》2019,20(4):573-593

Asia Pacific Education Review - In the last few years, adoption of service learning in higher educational institutions has emerged as a modern teaching and learning strategy. This study is aimed to...  相似文献   

Convergent genomic signatures of high-altitude adaptation among domestic mammals     

Dong-Dong Wu  Cui-Ping Yang  Ming-Shan Wang  Kun-Zhe Dong  Da-Wei Yan  Zi-Qian Hao  Song-Qing Fan  Shu-Zhou Chu  Qiu-Shuo Shen  Li-Ping Jiang  Yan Li  Lin Zeng  He-Qun Liu  Hai-Bing Xie  Yun-Fei Ma  Xiao-Yan Kong  Shu-Li Yang  Xin-Xing Dong  Ali Esmailizadeh  David M Irwin  Xiao Xiao  Ming Li  Yang Dong  Wen Wang  Peng Shi  Hai-Peng Li  Yue-Hui Ma  Xiao Gou  Yong-Bin Chen  Ya-Ping Zhang 《国家科学评论(英文版)》2020,7(6):952

Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence. Here, we used 327 genomes from horses, sheep, goats, cattle, pigs and dogs living at both high and low altitudes, including 73 genomes generated for this study, to disentangle the genetic mechanisms underlying local adaptation of domestic mammals. Although molecular convergence is comparatively rare at the DNA sequence level, we found convergent signature of positive selection at the gene level, particularly the EPAS1 gene in these Tibetan domestic mammals. We also reported a potential function in response to hypoxia for the gene C10orf67, which underwent positive selection in three of the domestic mammals. Our data provide an insight into adaptive evolution of high-altitude domestic mammals, and should facilitate the search for additional novel genes involved in the hypoxia response pathway.  相似文献   

Machine learning-enabled multiplexed microfluidic sensors     

Sajjad Rahmani Dabbagh  Fazle Rabbi  Zafer Doan  Ali Kemal Yetisen  Savas Tasoglu 《Biomicrofluidics》2020,14(6)

High-throughput, cost-effective, and portable devices can enhance the performance of point-of-care tests. Such devices are able to acquire images from samples at a high rate in combination with microfluidic chips in point-of-care applications. However, interpreting and analyzing the large amount of acquired data is not only a labor-intensive and time-consuming process, but also prone to the bias of the user and low accuracy. Integrating machine learning (ML) with the image acquisition capability of smartphones as well as increasing computing power could address the need for high-throughput, accurate, and automatized detection, data processing, and quantification of results. Here, ML-supported diagnostic technologies are presented. These technologies include quantification of colorimetric tests, classification of biological samples (cells and sperms), soft sensors, assay type detection, and recognition of the fluid properties. Challenges regarding the implementation of ML methods, including the required number of data points, image acquisition prerequisites, and execution of data-limited experiments are also discussed.  相似文献   

A comparison between two different automated total 25-hydroxyvitamin D immunoassay methods using liquid chromatography-tandem mass spectrometry     

Fatma Emel Kocak  Bahadir Ozturk  Ozben Ozden Isiklar  Ozlem Genc  Ali Unlu  Irfan Altuntas 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(3):430-438

Introduction

Total 25-hydroxyvitamin D [25(OH)D] is the most reliable indicator of vitamin D status. In this study, we compared two automated immunoassay methods, the Abbott Architect 25-OH Vitamin D assay and the Roche Cobas Vitamin D total assay, with the liquid chromatography-tandem mass spectrometry (LC-MS/MS).

Materials and methods

One hundred venous blood samples were randomly selected from routine vitamin D tests. Two of the serum aliquots were analyzed at the Abbott Architect i2000 and the Roche Cobas 6000’s module e601 in our laboratory within the same day. The other serum aliquots were analyzed at the LC-MS/MS in different laboratory. Passing-Bablok regression analysis and Bland-Altman plot were used to compare methods. Inter-rater agreement was analyzed using kappa (κ) analysis.

Results

The Roche assay showed acceptable agreement with the LC-MS/MS based on Passing-Bablok analysis (intercept: -5.23 nmol/L, 95% CI: -8.73 to 0.19; slope: 0.97, 95% CI: 0.77 to 1.15). The Abbott assay showed proportional (slope: 0.77, 95% CI: 0.67 to 0.85) and constant differences (intercept: 17.08 nmol/L; 95% CI: 12.98 to 21.39). A mean bias of 15.1% was observed for the Abbott and a mean bias of -14.1% was observed for the Roche based on the Bland-Altman plots. We found strong to nearly perfect agreement in vitamin D status between the immunoassays and LC-MS/MS. (κ: 0.83 for Abbott, κ: 0.93 for Roche) using kappa analysis.

Conclusion

Both immunoassays demonstrated acceptable performance, but the Roche Cobas assay demonstrated better performance than the Abbott Architect in the studied samples.Key words: 25-Hydroxyvitamin D, chromatography, immunoassay, methods, tandem mass spectrometry  相似文献   

Repulsion-based model for contact angle saturation in electrowetting     

Hassan Abdelmoumen Abdellah Ali  Hany Ahmed Mohamed  Mohamed Abdelgawad 《Biomicrofluidics》2015,9(1)

We introduce a new model for contact angle saturation phenomenon in electrowetting on dielectric systems. This new model attributes contact angle saturation to repulsion between trapped charges on the cap and base surfaces of the droplet in the vicinity of the three-phase contact line, which prevents these surfaces from converging during contact angle reduction. This repulsion-based saturation is similar to repulsion between charges accumulated on the surfaces of conducting droplets which causes the well known Coulombic fission and Taylor cone formation phenomena. In our model, both the droplet and dielectric coating were treated as lossy dielectric media (i.e., having finite electrical conductivities and permittivities) contrary to the more common assumption of a perfectly conducting droplet and perfectly insulating dielectric. We used theoretical analysis and numerical simulations to find actual charge distribution on droplet surface, calculate repulsion energy, and minimize energy of the total system as a function of droplet contact angle. Resulting saturation curves were in good agreement with previously reported experimental results. We used this proposed model to predict effect of changing liquid properties, such as electrical conductivity, and system parameters, such as thickness of the dielectric layer, on the saturation angle, which also matched experimental results.  相似文献   

Effect of perceived ease of use on librarians' e-skills: Basis for library technology acceptance intention     

Roland Izuagbe  Nurudeen Ademola Ibrahim  Lilofa Osamienfa Ogiamien  Olajumoke Rebecca Olawoyin  Nwanne Mary Nwokeoma  Promise Ifeoma Ilo  Odaro Osayande 《Library & information science research》2019,41(3):100969

Despite the widespread application of technology in the 21st century, making informed decisions regarding its acceptance in organisations is a function of several factors, particularly in developing countries, due to factors such as rising cost of the information technology infrastructure and low technological exposure. A model that incorporated perceived ease of use (PEOU) and e-Skills to examine librarians' intention for actual library technology acceptance was tested. The correlational research design, along with a multistage sampling procedure, was applied to select samples to reduce the sample to a manageable proportion. Professional librarians and library officers in four university libraries provided the data for the study. Results showed that e-Skill is the model's strongest determinant of technology acceptance intention among librarians. Also, PEOU will significantly moderate librarians' intention towards library technology acceptance when e-Skills are insufficient. From these outcomes, the understanding of the determinants of behavioural intention captured in the Technology Acceptance Model (TAM) and the Unified Theory of Acceptance and Use of Technology (UTAT) is extended and refined.  相似文献   

Palestinian media landscape: Experiences,narratives, and agendas of journalists under restrictions     

Ibrahim Hazboun  Ifat Maoz  Menahem Blondheim 《The Communication Review》2019,22(1):1-25

This study aims to increase our understanding of the dynamics of the Palestinian media and the conditions and circumstances in which they work, including both the conflict with Israel and the internal political strife within Palestinian society. It is based on the use of qualitative research methods and was conducted in two stages. First, we performed a mapping of Palestinian media outlets. Data on these Palestinian media outlets were collected online from the West Bank-based Palestinian Authority’s Ministry of Information website, the Gaza-based Hamas government’s Ministry of Information website, and statements published by Palestinian media outlets on their websites describing their affiliation and ownership. Second, to gain a more in-depth understanding of the dynamics and experience of practicing journalism in a situation of asymmetrical conflict, semistructured in-depth interviews were conducted with 25 professional local Palestinian journalists working for local media outlets in the Gaza Strip, the West Bank, and East Jerusalem. Through this study we aim to learn more about how groups shape and express their narratives and agendas through the media when restricted by the conditions, pressures, and limitations of asymmetrical conflict.  相似文献