青春雨     

a.com@qq.com 《初中生》2009,(7)

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Advances in urinary protein biomarkers for urogenital and non-urogenital pathologies     

Johanna Pedroza-Díaz  Sarah R?thlisberger 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(1):22-35

The discovery of protein biomarkers that reflect the biological state of the body is of vital importance to disease management. Urine is an ideal source of biomarkers that provides a non-invasive approach to diagnosis, prognosis and prediction of diseases. Consequently, the study of the human urinary proteome has increased dramatically over the last 10 years, with many studies being published. This review focuses on urinary protein biomarkers that have shown potential, in initial studies, for diseases affecting the urogenital tract, specifically chronic kidney disease and prostate cancer, as well as other non-urogenital pathologies such as breast cancer, diabetes, atherosclerosis and osteoarthritis. PubMed was searched for peer-reviewed literature on the subject, published in the last 10 years. The keywords used were “urine, biomarker, protein, and/or prostate cancer/breast cancer/chronic kidney disease/diabetes/atherosclerosis/osteoarthritis”. Original studies on the subject, as well as a small number of reviews, were analysed including the strengths and weaknesses, and we summarized the performance of biomarkers that demonstrated potential. One of the biggest challenges found is that biomarkers are often shared by several pathologies so are not specific to one disease. Therefore, the trend is shifting towards implementing a panel of biomarkers, which may increase specificity. Although there have been many advances in urinary proteomics, these have not resulted in similar advancements in clinical practice due to high costs and the lack of large data sets. In order to translate these potential biomarkers to clinical practice, vigorous validation is needed, with input from industry or large collaborative studies.Key words: urine, protein, biomarker  相似文献   

Physicochemical and Functional Properties of Vegetable and Cereal Proteins as Potential Sources of Novel Food Ingredients     

Cintya Soria-Hernández  Sergio Serna-Saldívar  Cristina Chuck-Hernández 《Food Technology and Biotechnology》2015,53(3):269-277

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The relevance of intellectual capital disclosure: empirical evidence from Spanish universities     

Yolanda?Ramírez-CórcolesEmail author  Montserrat?Manzaneque-Lizano 《知识管理研究与实践》2015,13(1):31-44

The reporting of intellectual capital (IC) in higher education institutions is of vital importance, mainly owing to the fact that knowledge is the main output and input in these institutions. Furthermore, the increasing social concern about establishing procedures of accountability and ensuring information transparency in public universities prompted us to consider the need to disclose information on their IC. In this study, we developed a questionnaire that was sent to members of the Social Councils of Spanish public universities in order to identify the intangible elements about which university stakeholders demand most information. It was also used to see which groups of universities have stakeholders who are more proactive to the disclosure of IC. Our results represent a starting point for public universities to identify the most commonly requested information about IC. Universities can then develop an IC report that fits their own characteristics and environment.  相似文献   

Effect of Tara (Caesalpinia spinosa) Pod Powder on the Oxidation and Colour Stability of Pork Meat Batter During Chilled Storage     

Monika Skowyra  Urszula Janiewicz  Anna Marietta Salejda  Gra?yna Krasnowska  María Pilar Almajano 《Food Technology and Biotechnology》2015,53(4):419-427

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Concentration and Purification of Yacon?(Smallanthus sonchifolius) Root Fructooligosaccharides?Using Membrane Technology     

Maria Julia Ledur Alles  Isabel Cristina Tessaro  Caciano Pelayo Zapata Nore?a 《Food Technology and Biotechnology》2015,53(2):190-200

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Pawns in a Chess Game     

Gloria García González 《Media History》2015,21(4):412-425

The Spanish Service was established in June 1939, two months after the end of the civil war in Spain and shortly before the start of the Second World War. Its implementation was strongly affected by these conflicts in the context of new international relations. Therefore, this study of the Spanish Service during 1939–1945 allows not only a better understanding of the communicational strategies developed by the BBC, but also of the complex Anglo-Spanish relations and the important role played by the Spanish-language broadcasts therein. The study is mainly based on archival documents from the National Archives in London and memoirs.  相似文献   

德国应用科技大学的办学特点及启示     

韩伏彬  董建梅 《衡水学院学报》2011,13(6):114-116

应用型大学办学模式的探讨需要广开思路,洋为中用。德国应用科技大学办学经验启示我们找准人才培养定位,实施灵活多样的人才培养模式,加大人才培养的实践力度,提高教师专业实践技能,突出科研的应用与转化等。  相似文献   

User experience of government documents: A framework for informing design decisions     

Leonardo Madariaga  Miguel Nussbaum  Faustino Marañón  Cristóbal Alarcón  María Alicia Naranjo 《Government Information Quarterly》2019,36(2):179-195

People still use documents in many everyday government processes. From tax payments to passport requests, citizens have to interact with low-interactivity information artifacts such as reports, maps and datasets, among many others. Despite efforts to improve information delivery in the public sector, effective information usage remains a critical topic of action and research. The user experience of government documents has rarely been assessed, despite them being regularly published and frequently used. Considering this, the two following research questions arise: 1) How can government documents be classified (or grouped) in terms of user experience? 2) How can the user experience of government documents be monitored over time in order to inform design decisions? Working with a public agency in Chile, we develop and test a classification and monitoring framework based on two online surveys (N?=?338 and N?=?298). We then propose a framework for understanding user experience of government documents in these three dimensions: interaction goal, volume of information and ease of understanding. Using a graphical representation to classify user experience provides greater visibility of the current status of information produced by a public organization. Furthermore, by monitoring the user experience of a government document at different times, organizations can understand the effect of their design decisions and improve their service quality by implementing user-centered processes.  相似文献   

Temporary Book Storage Using a Document Management Company     

Meredith Giffin  Kirsten Huhn  Andréa Harland 《资料收集管理》2019,44(1):46-68

Finding an appropriate temporary storage location for books and providing access to them is a significant challenge for libraries undergoing renovations. The current article describes the use of a document management company by an academic library to store 430,000 books for 8 months and provide a retrieval-on-demand service. Aspects covered include the selection of a commercial storage provider with its own retrieval service; details of the move to and from offsite storage; the integration of the service with library processes; communications and user feedback; book usage during the storage period; overall costs; and lessons learned from the experience.  相似文献