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61.
Daniel Muise 《亚洲交流杂志》2019,29(3):217-234
ABSTRACTChanges in information communication technology across the Asian region have altered our field substantively and methodologically. The rapid growth of digitized communications allows us to find new purchase in examining questions fundamental to our understanding of communication theories, norms, and practices across Asia. While methods such as text mining and user analytics are increasingly popular among computational scholars, here, we focus on online field experiments, an approach to studying communication that has the potential to overcome many existing obstacles to social scientific inquiry but one that has been used relatively rarely in Asia. In this paper, we discuss what online field experiments are and how they differ from traditional experiments as well as online lab and survey experiments. We show how researchers can go about designing and implementing online field experiments, focusing on issues where online field experiments differ from their traditional counterparts – legal and ethical considerations, construct validity, randomization and spillover, and statistical analyses. Finally we discuss how online field experiments can advance our understanding of communication in Asia by helping researchers to gain insight and make causal inferences on attitudes, behaviors, and interactions that were previously unobservable ?. 相似文献
62.
结合本校的实际情况,对目前药物分析实验教学中存在的问题进行分析,讨论了仿真实验在实验教学中的作用、弊端及对策。 相似文献
63.
随着幕课在中国教育界的迅猛发展,其已经受到了高校教师的重视。什么是好的幕课,如何制作一门好的幕课,如何在大规模在线教学领域占一席之地,已经成为每一个高校教师必须要思考的问题。基于此,就幕课的起源发展和特性进行综述,剖析理想幕课的模式和在幕课建设中应注意的问题,以期为高等院校幕课建设提供参考和借鉴。 相似文献
64.
Gururao Hariprasad Divya Kota Sundararajan Baskar Singh Alagiri Srinivasan Souparno Adhikary 《Indian journal of clinical biochemistry : IJCB》2014,29(4):430-441
Clonorchis sinensis or the Chinese liver fluke is one of the most prevalent parasites affecting a major population in the oriental countries. The parasite lacks lipid generating mechanisms but is exposed to fatty acid rich bile in the liver. A secretory phospholipase A2, an enzyme that breaks down complex lipids, is important for the growth of the parasite. The enzyme is also implicated in the pathogenesis leading up to the hepatic fibrosis and its complications including cancer. The five isoforms of this particular enzyme from the parasite therefore qualify as potential drug targets. In this study, a detailed structural and ligand binding analysis of the isoforms has been done by modeling. The overall three dimensional structures of the isoforms are well conserved with three helices and a β-wing stabilized by four disulfide bonds. There are characteristic differences at the calcium binding loop, hydrophobic channel and the C-terminal domain that can potentially be exploited for drug binding. But the most significant feature pertains to the catalytic site where the isoforms exhibit three variations of either a histidine-aspartate-tyrosine or histidine-glutamate-tyrosine or histidine-aspartate-phenylalanine. Molecular docking studies show that isoform specific residues and their conformations in the substrate binding hydrophobic channel make unique interactions with certain inhibitor molecules resulting in a perfect tight fit. The proposed ligand molecules have a predicted affinity in micro-molar to nano-molar range. Interestingly, few of the ligand binding interaction patterns is in accordance to the phylogenetic studies to thereby establish the usefulness of evolutionary mechanisms in aiding ligand design. The molecular diversity of the parasitic PLA2 described in this study provides a platform for personalized medicine in the therapeutics of clonorchiasis.
Electronic supplementary material
The online version of this article (doi:10.1007/s12291-013-0377-1) contains supplementary material, which is available to authorized users. 相似文献65.
实验课对天然药物化学教学有着关键性影响,在其中引入设计性实验教学是对现有实验课程的一次探索性改革。设计性实验教学方案的构建和实施需要从课题选择、方案设计、实验准备、实验实施及结果分析等多个环节入手,在教学实践中这种教学方式取得了良好的效果。 相似文献
66.
物理是一门实验学科,在高中物理教学中,实验一直贯穿于物理教学的始终。随着近年来我国教育体系的不断改革,在新课标体系下,学校和老师越来越重视高中物理实验。物理实验不仅仅体现在平时的教学中,在高考物理中占据的分数比例也非常大。因此,学校应该加强高中物理实验教学,培养学生的实验意识,提高学生的实验能力水平,从而在高考中取得优异的成绩,为国家人才培养和高等学校录取人才提供强有力的保证。 相似文献
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68.
说课是教师在备课的基础上,口头向同行和专家叙述具体课题的教学设计及其依据的一种教学研究活动。它能集中体现和反映教师的教育教学观念、教学能力和教学水平。文章以“定积分的应用”(2学时)为例,根据高职教育和学生特点,从大纲及教材、学情、教法、教学过程以及自我评价等几个方面进行阐述,以期与各位同行共勉。 相似文献
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70.
实验室制取NO2、NO的反应,由于其毒性,实验装置的改良备受关注,笔者进行了进一步的改进,旨在减少试剂用量、减轻尾气毒害,人人有机会动手实践,这一点符合绿色化学的发展理念。 相似文献