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31.
32.
Dao-fa Tian Ying-chun He Fang-guo Lu Fa-qing Tang 《Journal of Zhejiang University. Science. B》2009,10(3):172-179
Objective To investigate the enhancive effect of N,N′-dinitrosopiperazine (DNP) on induced carcinogenesis in nasal and/or nasopharyngeal epithelia among TgN(p53mt-LMP1)/HT transgenic
mice to examine the underlying mechanism for the development of nasopharyngeal carcinoma (NPC).
Methods TgN(p53mt-LMP1)/HT transgenic mice and the same strain of C57BL/6J wild-type mice both at the age of 5 months were randomly divided into 2 groups in parallel, respectively, i.e., TgN(p53mt-LMP1)/HT
cancerous lesion-inducing group (TI), TgN(p53mt-LMP1)/HT control group (TC), C57BL/6J cancerous lesion-inducing group (CI), and C57BL/6J control group (CC). TI and CI mice were treated only with DNP for 16 weeks, twice each week, while TC and CC mice were
given the same volume of saline as controls. At the end of treatment, animals were sacrificed to collect epithelial tissue
samples from nasal cavity and nasopharynx for pathohistological evaluation by haematoxylin and eosin (HE) staining and for
determination on the expression of TRAF2, c-Jun, and p16 by immunohistochemistry.
Results Atypical hyperplasia was more significant in the samples of TI than in those of TC, CI, and CC, with the rates of lesions
being 90%, 10%, 0, and 0 (P<0.01) respectively, though DNP was used alone in a much shortened inducing period at less dosage and without the use of carcinogenic
promoter 12-O-tetradecanoylphorbol-13-acetate as usual. The expressions of tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2)
and c-Jun in these samples were significantly up-regulated in TI (P<0.01), while the expression of p16 was significantly lower in TI than in the other groups (P<0.01).
Conclusion TgN(p53mt-LMP1)/HT mice hold inherited constitutional defect in immune surveillance function, which can be aggravated by environmental
carcinogens, such as DNP used even though in a much less strength. The enhanced carcinogenesis-inducing effect of DNP on TgN(p53mt-LMP1)/HT
mice should be closely associated with abnormal signaling of activator protein-1 (AP-1) pathway, especially up-regulated expressions
of TRAF2 and c-Jun, and down-regulated expression of p16.
Project supported by the National Natural Science Foundation of China (Nos. 30672738, 30572455 and 30572408), Hunan Provincial
Natural Science Foundation for Distinguished Young Scholars (No. 03JJY1006) and for General Projects (Nos. 05JJ40029 and 07JJ6038),
the Research Foundation of Hunan Provincial Scientific and Technological Department for International Cooperative Academic
Projects (No. 06WK3016), and the Research Foundation of Hunan Provincial Education Department for Outstanding Young Scholars
(No. 06B070), China 相似文献
33.
Least squares support vector machines (LS-SVMs) are modified support vector machines (SVMs) that involve equality constraints and work with a least squares cost function, which simplifies the optimization procedure. In this paper, a novel training algorithm based on total least squares (TLS) for an LS-SVM is presented and applied to multifunctional sensor signal reconstruction. For three different nonlinearities of a multifunctional sensor model, the reconstruction accuracies of input signals are 0.00136%, 0.03184% and 0.504 80%, respectively. The experimental results demonstrate the higher reliability and accuracy of the proposed method for multifunctional sensor signal reconstruction than the original LS-SVM training algorithm, and verify the feasibility and stability of the proposed method. 相似文献
34.
35.
陈凤苏 《广东广播电视大学学报》2003,12(2):82-84
介绍了用软件和硬件相结合的方法识别电话信号音,为自动拨号远程控制系统电话音识别提供了实践电路和应用程序。 相似文献
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专网通信中的模拟中继电路的信号电平失调是一种常见的问题.通过分析信号电平调整的原理,提出了2种能够实现信号电平自动调整的改良性方法.一种为模拟式信号电平自动调节,以导频信号为基础,通过调节可控增益放大器白动调节话音信号的电平变化.另一种为数字式信号电平自动调节,先将导频信号进行A/D转换并生成一个基准数值,通过PC机程序改变该基准数值的变化,达到调整语号信号电平的目的. 相似文献
38.
基于LabVIEW的振动测试分析系统 总被引:4,自引:0,他引:4
基于LabVIEW的振动测试分析系统由系统硬件和振动测试分析软件两大部分组成.其中,振动测试分析软件是本系统的核心.振动测试分析软件的主要功能是控制数据采集板进行数据采集;根据信号处理的基本原理,对采集的数据进行幅值谱分析、自相关分析、互相关分析、自功率谱分析、互功率谱分析、相干函数分析等. 相似文献
39.
本文结合“数字信号处理”这门课程的特点,为使传统的课堂型教学逐渐过渡到探索型教学,从教学内容、教学方法以及教学实践等方面进行了实践和探讨。 相似文献
40.