Expression of TGF-β1 and TGF-β R II in colorectal adenomas of varying stages     

Wang Da  He Chao  Ding Wei  Wang Hui-ping 《浙江大学学报(A卷英文版)》2001,2(1):107-110

To study the function of transforming growth factor β₁ (TGF-β₁) and transforming growth factor-β type II receptor (TGF-βR II) in varying stages of colorectal adenoma during neoplastic transformation, fiftyfive cases of resected colorectal adenomas were examined immunohistochemically. Our results showed that the expression of TGF-β₁ ranged from high to low, with the progression of low-grade to high-grade dysplasia of adenomas to carcinoma. And there was significantly different expression of TGF-β₁ between moderate and high dysplasia adenomas (P<0.05), but no significantly different expression of TGF-β R II was found among varying stages of adenomas. Our results suggested that the quantities of TGF-β₁ secreted by adenoma cells decrease dramatically in moderate to severe dysplasia colorectal adenomas. It is the decreased secretion of TGF-β₁, rather than the mutated TGF-βR II that may play an important role in transforming colorectal adenomas to adenocarcinomas.  相似文献   

铜(Ⅱ)-头孢唑啉钠络合物吸附波的研究与应用     

孟召辉 《南阳师范学院学报》2003,2(6):47-50

在pHl0的NH3-NH4C1缓冲溶液中，Cu(Ⅱ)-头孢唑啉钠络合物在单扫描示波极谱仪上产生一灵敏的还原峰，其一次导数峰电位为-0．30V(vs．SCE)，峰电流与铜浓度在0．005—0．3mg／L范围内呈线性关系，检出限为0．0025mg／L。将该波用于人发及硫酸镍中铜含量的测定，并就极谱波的性质进行了探讨。  相似文献   

Rose Blanche in Translation     

Susan Stan 《Children‘s Literature in Education》2004,35(1):21-33

This comparative study focuses on three editions of Rose Blanche, Roberto Innocenti's picturebook portrayal of a young girl who discovers a Nazi concentration camp on the outskirts of her German city. The original text, written in French by Christophe Gallaz to accompany Innocenti's illustrations, was translated into English and published in the United States; this text is compared with the British text, rewritten by Ian McEwan, and the German text, translated by Abraham Teuter. An examination of differences in the three texts demonstrates some of the ways in which cultural, aesthetic, national, ideological, pedagogical, and economic issues influence the translation of a children's book.  相似文献   

Risk factors for coronary heart disease in type II diabetes mellitus     

H. Surekha Rani  G. Madhavi  V. Ramachandra Rao  B. K. Sahay  A. Jyothy 《Indian journal of clinical biochemistry : IJCB》2005,20(2):75-80

Cardiovascular complications are the major cause of morbidity and mortality in diabetic patients. An attempt has been made to evaluate the risk factors for coronary heart disease in type II diabetics. In the present study the levels of fasting and postprandial plasma glucose, total cholesterol, low density lipoproteins, triglycerides were high and the levels of high density lipoproteins were low in the type II diabetics compared to controls. The markers of free radical induced injury i.e. malondialdehyde and nitrite/nitrate were high while total antioxidant status a marker for antioxidant protection against reactive oxygen species was low in diabetics compared to controls. The study therefore suggests the importance of assessing these markers of oxidative stress and antioxidant capacity along with the other routine investigations in diabetic patients for initiating antioxidant therapy in addition to primary and secondary preventive measures to mitigate the devastating consequences of diabetes leading to coronary heart disease.  相似文献   

抗坏血酸存在下六氮杂铜配合物修饰金电极对多巴胺的分析测定     

吴海霞  董树清  康敬万  冯文成  杨西萍  高兰玲 《兰州石化职业技术学院学报》2009,9(2):1-5

利用自组装的方法制备了一种新型六氮杂铜配合物修饰的金电极。采用循环伏安法和电化学隧道扫描显微镜对该电极进行了表征。计算了该电极电子转移系数为0.42,标准速率常数为38S^-1。该电极可以有效地催化氧化多巴胺,当抗坏血酸浓度为1-5mmol/L时,可用于多巴胺的分析测定,检测限低至1.8×10^-8mol/L。  相似文献   

从俾斯麦到威廉二世——德意志第二帝国外交政策的转变及其影响     

沈劼 《黄石理工学院学报(人文社科版)》2009,26(5):66-70

本文着重考察了德意志第二帝国外交政策的转变过程,分析了导致其转变发生的国际、国内和个人因素,并进一步探讨了德国外交政策的转变对当时国际政治关系所产生的影响。德国作为一个中欧大国,在转向争取世界霸权的过程中,其外交政策的得失是值得我们深思的。  相似文献   

Extent of type I and type II errors in editorial decisions: A case study on Angewandte Chemie International Edition     

Lutz Bornmann  Hans-Dieter Daniel   《Journal of Informetrics》2009,3(4):348-352

  相似文献   

威廉二世时代德国的战略困境及其成因分析     

胡杰 《信阳师范学院学报(哲学社会科学版)》2010,30(2):153-156

威廉二世时代德国的战略困境主要表现为：在地缘政治上,同英、俄两大洲际强国的战略矛盾难以调和;在经济与社会环境上,工业化时代欧洲社会的转型,使极端民族主义情绪甚嚣尘上,矛盾与斗争成为主旋律,加剧了协调的困难;在决策层面上,德国政治精英刻板蛮横、一味强硬的思维模式构成了决策层面的战略困境。这种困境的形成,既有国际环境和德国社会发展的原因,也受到德国决策者个人因素的影响。  相似文献   

国外机构知识库研究的可视化分析     

武同雁 《现代情报》2017,37(8):161-166

本文以CiteSpace Ⅱ为工具,以Web of Science中的相关文献为信息源,采用可视化分析方法,对国外机构知识库研究领域的经典文献、重要作者、重要期刊和研究热点进行了定量分析与可视化呈现,以期能对我国机构知识库的研究有所启发。  相似文献   

双核铜(II)配合物[Cu(α-Furoicacid)_2(H_2O)]_2·(H_2O)_2的合成、晶体结构及电化学研究     

李薇  陈志敏  杨颖群  徐伟箭 《衡阳师范学院学报》2006,(3)

在甲醇水混合溶剂中合成了标题配合物Cu2(-αfuroic acid)4(H2O)4,测定了其晶体结构,晶体属单斜晶系,空间群P2(1)/c,晶胞参数:a=1.0106(4)nm,b=1.046(6)nm,c=2.00790nm;β=91.118(8)°,V=2.646(2)nm3,Dc=1.619g/cm3,Z=4,F(000)=1306.最终偏离因子R1=0.0567,wR2=0.1676,两个Cu(II)由四个呋喃甲酸根桥联且其端位各有一个水分子配位,形成一个具有畸变的四角锥形配位环境。配合物中Cu(II)-Cu(II)间具有一对称中心,其Cu(II)-Cu(II)的间距为0.2637nm,结合晶体结构对配合物进行了电化学性质研究。  相似文献