pre-operative serum potassium levels and peri-operative outcomes in patients undergoing cardiac surgery     

O. P. Sanjay 《Indian journal of clinical biochemistry : IJCB》2004,19(1):40-44

Although potassium is critical for normal electro physiology, the associations between pre-operative serum potassium level and peri-operative adverse events such as arrhythmias in cardiac surgery have not been examined in detail. The objective of this study was to determine the prevalence of abnormal pre-operative serum potassium levels and whether such levels were associated with adverse peri-operative events in 50 patients undergoing coronary artery bypass grafting. Intra-operative and post-operative arrhythmias, the need for cardio-pulmonary resuscitation, cardiac death and death due to any cause prior to discharge from the post-operative intensive care unit were studied. The incidence for adverse outcome was 0.5% for death, 0.5% for cardiac death and 2% for cardio pulmonary resuscitation in patients with hypokalemia (serum potassium level <3.5 meq. L⁻¹). Hypokalemia was found to be a predictor of serious peri-operative (OR:2.2; 95% Cl: 1.2–4.1) and post-operative arrhythmias (OR: 1.7;95%Cl: 1.0–2.7). Pre-operative potassium repletion is low cost and low risk treatment measure and the data from this study suggests that screening and repletion be considered in patients scheduled for cardiac surgery.  相似文献   

Refining Students’ Explanations of an Unfamiliar Physical Phenomenon-Microscopic Friction     

Corpuz  Edgar De Guzman  Rebello  N. Sanjay 《Research in Science Education》2019,49(5):1177-1211

Research in Science Education - The first phase of this multiphase study involves modeling of college students’ thinking of friction at the microscopic level. Diagnostic interviews were...  相似文献   

Effects of short-term hormone replacement on atherogenic indices in Indian postmenopausal women     

Sarika Arora  Anju Jain  R Chitra 《Indian journal of clinical biochemistry : IJCB》2006,21(1):41-47

Indian ethnicity by itself is a strong risk factor for development of CAD in Indian postmenopausal women due to lower HDL levels as compared to Whites and women of oriental origin. We evaluated and compared the short-term effects of menopause, estrogen replacement therapy and combined estrogen and progestin replacement therapy on various atherogenic indices. 40 postmenopausal women, both surgical and natural (20 each) were selected. 10 surgical postmenopausal women were given 0.625 mg conjugated estrogens daily for 6 months and 10 natural postmenopausal women were given 0.625 mg conjugated estrogen with 2.5 mg medroxyprogesterone acetate daily. 20 women were included in the control group and given placebo. Fasting venous blood samples were analyzed for extended lipid profile and calculated atherogenic indices before starting the therapy and after 1,3 and 6 months. LDL and Apolipoprotein B increased (p<0.05) and those of Apolipoprotein A1 and HDL decreased in the control groups. In both the study groups levels of serum cholesterol and LDL decreased (p<0.05) and those of HDL and Apolipoprotein A1 increased (p<0.01). LDL/HDL, Apo B/ApoA1, Total Cholesterol/HDL decreased significantly (p<0.05) in both the study groups compared to the control groups. The effect of estrogen alone was more significant as compared to combination therapy. Log Triglycerides (TG)/HDL ratio showed a decrease in women on estrogen alone but the difference was not significant. Our study confirms that short term HRT has a favorable effect on atherogenic indices in Indian postmenopausal women.  相似文献   

Unusual changes in colostrum composition in lactating Indian women having medical complications during pregnancy—A pilot study     

S. Kaushik  S. S. Trivedi  A. Jain  J. Bhattacharjee 《Indian journal of clinical biochemistry : IJCB》2002,17(2):68-73

Colostrum, the mammary secretion during first 2–4 days of lactation, provides all the essential components of nutrition and passive immunity required by the newborn. Pregnancy induced hypertension (PIH), glucose intolerance and anaemia are common medical complications observed during pregnancy in Indian women and their effects were studied on the composition of colostrum collected within 24 hours of delivery from lactating women included in the study. PIH during pregnancy significantly decreased colostrum IgA and total proteins, but showed a significant increase in K⁺ levels, where as women with glucose intolerance showed a significant decrease in total lipids and lactose and an increase in Na⁺ levels in colostrum compared to normal controls. The group with anaemia also showed a significant decrease in colostrum IgA and total protein levels when compared with the control group. Awareness about the changes that occur in the composition of colostrum during complicated pregnancies can be an important and useful tool for preventive and protective paediatrics.  相似文献   

Role of yoga in control of hyperglycemia in middle aged patients of non-insulin dependent diabetes mellitus     

Suresh Chander Jain  Bandana Talukdar 《Indian journal of clinical biochemistry : IJCB》1995,10(2):62-65

The effect of 40 days yoga training in 30 hospitalized non-insulin dependent diabetes mellitus (NIDDM) patients has been investigated after stopping the medication. Blood glucose response to oral glucose load measured as area index total (AIT), glycated haemoglobin (GHb) plasma lipids and lipoproteins measurements before and after yoga training have been compared. Yoga training resulted in a significant improvement in AIT, GHb and plasma triglycerides and cholesterol levels. The data suggest that yoga training along with diet and medical management provides an important metabolic control in NIDDM and may have a role in primary prevention of diabetes mellitus.  相似文献   

The racialized surveillant assemblage: Islam and the fear of terrorism     

Sanjay Sharma  Jasbinder Nijjar 《Popular Communication》2018,16(1):72-85

ABSTRACT

Increasingly intense, multifaceted, and integrated forms of surveillance are a central feature of Western national security attempts to counter the violence of “Islamic terrorism.” However, there has been a lack of research examining contemporary regimes of surveillance as profoundly racialized. This study examines how counterterrorism efforts are underpinned by ill-conceived accounts of radicalization that preemptively construct Muslim migrants as a threat to national security, thereby justifying practices of mass surveillance that further propagate racist discourses of uncertainty and risk. We advance an analysis of a racialized surveillant assemblage, which is generative of mutable, algorithmically determined profiles of the Muslim-as-terrorist. Such a regime of mass surveillance effectively puts all Muslims under suspicion. We highlight that, paradoxically, mass data-mining operations stifle, rather than aid, the identification of actual terrorist threats. This conditions a paranoid surveillant racism, through which Muslim populations become modulated as an unknowable threat of death and destruction.  相似文献   

An inexpensive microfluidic device for three-dimensional hydrodynamic focusing in imaging flow cytometry     

Yogesh M. Patel  Sanidhya Jain  Abhishek Kumar Singh  Kedar Khare  Sarita Ahlawat  Supreet Singh Bahga 《Biomicrofluidics》2020,14(6)

We present design, characterization, and testing of an inexpensive, sheath-flow based microfluidic device for three-dimensional (3D) hydrodynamic focusing of cells in imaging flow cytometry. In contrast to other 3D sheathing devices, our device hydrodynamically focuses the cells in a single-file near the bottom wall of the microchannel that allows imaging cells with high magnification and low working distance objectives, without the need for small device dimensions. The relatively large dimensions of the microchannels enable easy fabrication using less-precise fabrication techniques, and the simplicity of the device design avoids the need for tedious alignment of various layers. We have characterized the performance of the device with 3D numerical simulations and validated these simulations with experiments of hydrodynamic focusing of a fluorescently dyed sample fluid. The simulations show that the width and the height of the 3D focused sample stream can be controlled independently by varying the heights of main and side channels of the device, and the flow rates of sample and sheath fluids. Based on simulations, we also provide useful guidelines for choosing the device dimensions and flow rates for focusing cells of a particular size. Thereafter, we demonstrate the applicability of our device for imaging a large number of RBCs using brightfield microscopy. We also discuss the choice of the region of interest and camera frame rate so as to image each cell individually in our device. The design of our microfluidic device makes it equally applicable for imaging cells of different sizes using various other imaging techniques such as phase-contrast and fluorescence microscopy.  相似文献   

Exploratory Analysis to Identify Concepts,Skills, Knowledge,and Tools to Educate Business Analytics Practitioners     

Marina E. Johnson  Abdullah Albizri  Rashmi Jain 《Decision Sciences Journal of Innovative Education》2020,18(1):90-118

Recent technological advancements in data storage and processing have changed how companies conduct their business. An increasing number of firms have started putting their efforts in extracting information from their databases to improve profitability and reduce costs using quantitative approaches. Thus, the job market has been experiencing a rapidly growing demand for business analytics (BA) practitioners, and universities across the globe are increasingly responding to this newly emerged field by offering both undergraduate and graduate level degrees as well as certificate programs. Thus, this research aims to provide a framework for academic institutions to develop a state‐of‐the‐art master's in business analytics (MSBA) curriculum by identifying concepts, skills, knowledge, and tools (CSKT) that industry seeks in BA practitioners. Our data‐driven methodology utilizes peer institution analysis, indeed.com web scraping, and focus group analysis with mid‐ and senior‐level analytics leaders from major companies. Our contribution to the literature and recommendations to institutions developing MSBA programs are offered at the end.  相似文献   

Association of Cholesteryl Ester Transfer Protein (CETP) Gene -629C/A Polymorphism with Angiographically Proven Atherosclerosis     

Anita Devi  Ritu Singh  Rajni Dawar  Sanjay Tyagi 《Indian journal of clinical biochemistry : IJCB》2017,32(2):235-238

Association of cholesteryl ester transfer protein (CETP) Gene -629C/A Polymorphism with angiographically proven atherosclerosis CETP gene has been linked to CAD risk via its role in HDL and LDL metabolism. There is no agreement of whether CETP is atherogenic or not. Furthermore, various genotypes of CETP gene have been associated with CETP levels and thus with atherosclerosis risk. Our aim was to study the association of CETP -629C/A gene polymorphism with CETP and HDL levels and their association if any with atherosclerosis. Study population consisted of angiographically documented 50 cases with coronary artery atherosclerosis and 50 controls negative for atherosclerosis of coronary artery. Serum lipid profile was measured on SYNCHRON CX-9 using standard kits. Serum CETP levels were measured by ELISA method. CETP -629C/A gene polymorphism was studied using PCR–RFLP method. There was no significant difference in lipid profile of the two groups. However, serum CETP level was significantly higher (46.44 ± 21.75 ng/ml) in cases than controls (37.10 ± 21.92 ng/ml) with p value =0.035. The frequency of -629A allele was higher (0.85) in cases than that of controls (0.81). Homozygosity of A allele was more in subjects with atherosclerosis of coronary artery. We conclude that CETP is atherogenic and could be used as atherogenic risk predictor in angiographically proven atherosclerosis. Also A allele of -629C/A polymorphism is more prevalent in cases; indicating its effect on expression of CETP gene.  相似文献   

A Microarray Immunoassay for Serum Thyrotropin and Thyroglobulin Using Antibodies Immobilized on Track-Etched Membranes     

Bharti Jain  J. Kumarasamy  Chandrakala Gholve  Savita Kulkarni  M. G. R. Rajan 《Indian journal of clinical biochemistry : IJCB》2017,32(2):193-199

Serum thyroglobulin (Tg) and thyroid stimulating hormone (TSH) measurements have evolved as important analytes for monitoring the prognosis of patients with differentiated thyroid cancer, post-thyroidectomy. Individual analyte immunoassay is the current practice in clinical pathology, but the simultaneous assay for all relevant analytes for a given disease, can reduce assay costs, improve patient compliance and give the clinician more information for an unequivocal diagnosis. Microarray immunoassay (MI) can achieve this goal and, hence, we have developed and validated a immuno-radiometric MI for quantitation of serum TSH and Tg by using highly micro-porous polycarbonate (PC) track-etched membranes (TEM) to immobilize the monoclonal anti-TSH and polyclonal anti-Tg antibodies in ~1 mm diameter spots. Non-competitive immunoassays were performed using mixture of ¹²⁵I labeled monoclonal anti-TSH and anti-Tg antibodies. Phosphorimager was used to quantify the bound radioactivity. TSH and Tg were detected with detection limit of 0.07 µIU/ml and 0.13 ng/ml respectively, which is lower than the clinically required cut-off level. The assay showed: acceptable intra-assay precision within 20 % and recovery in the range of 76–111.2 %. MI compared well with the established immunoradiometric assay (IRMA) with r = 0.98, p < 0.01 (n = 41). No cross-reactivity was seen between the immobilized antibodies. Although two hormones are addressed in this report, MI using PC TEM and isotopic/non-isotopic tracers has the potential for highly automated multiplexed analysis.  相似文献