Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

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教练员与运动员关系的研究   总被引：7，自引：0，他引：7  

程云峰  姜丽  杨太胜  王阜存  李金珠  张晓蓬 《山西师大体育学院学报》2002,17(2):51-53

我国竞技体育,教练员与运动员关系好的不乏其人,他们努力训练,通力合作,为我国的竞技体育的腾飞作出了卓越的贡献,但也有些教练员与运动员关系不融洽,使运动员过早地离开运动场,失去了为国争光的机会。文章通过教练员和运动员关系的研究,旨在为提高竞技运动水平和教练员在选材、训练时提供参考。  相似文献   

健康——不可忽视的人力资本投资     

傅玲  白文飞 《首都体育学院学报》2002,14(3):27-28

健康作为一种人力资本投资对提高生产力、促进经济发展和个人发展有着重要的作用。它可以提高劳动者的生产效率，刺激教育方面的投资，使人具有更多的时间和能力利用其他资本要素，具有更大的财力（因减少医疗费用）用于其他方面的投资。所以进行人力资本投资时，不可忽视健康这一要素，它也是人力资本形成的重要途径，也对经济增长起着有力的推动作用。  相似文献   

A comparison of the anthropometric, strength, endurance and flexibility characteristics of female elite and recreational climbers and non-climbers.     

S Grant  T Hasler  C Davies  T C Aitchison  J Wilson  A Whittaker 《Journal of sports sciences》2001,19(7):499-505

There is limited information on the anthropometry, strength, endurance and flexibility of female rock climbers. The aim of this study was to compare these characteristics in three groups of females: Group 1 comprised 10 elite climbers aged 31.3 +/- 5.0 years (mean +/- s) who had led to a standard of 'hard very severe'; Group 2 consisted of 10 recreational climbers aged 24.1 +/- 4.0 years who had led to a standard of 'severe'; and Group 3 comprised 10 physically active individuals aged 28.5 +/- 5.0 years who had not previously rock-climbed. The tests included finger strength (grip strength, finger strength measured on climbing-specific apparatus), flexibility, bent arm hang and pull-ups. Regression procedures (analysis of covariance) were used to examine the influence of body mass, leg length, height and age. For finger strength, the elite climbers recorded significantly higher values (P < 0.05) than the recreational climbers and non-climbers (four fingers, right hand: elite 321 +/- 18 N, recreational 251 +/- 14 N, non-climbers 256 +/- 15 N; four fingers, left hand: elite 307 +/- 14 N, recreational 248 +/- 12 N, non-climbers 243 +/- 11 N). For grip strength of the right hand, the elite climbers recorded significantly higher values than the recreational climbers only (elite 338 +/- 12 N, recreational 289 +/- 10 N, non-climbers 307 +/- 11 N). The results suggest that elite climbers have greater finger strength than recreational climbers and non-climbers.  相似文献   

Cerebral activity prior to motion task performance: an electroencephalographic study     

D Collins  G Powell  I Davies 《Journal of sports sciences》1991,9(3):313-324

Cerebral activity, as reflected by power in the alpha waveband (8-13 Hz), was examined prior to the performance of three tasks with different effort and accuracy requirements. The study aimed to further investigate changes in activity observed in an earlier study in which expert karate performers exhibited significant increases in alpha band power during preparation for a training task. In contrast to the earlier research, the high effort task produced a significant decrease in 'alpha' power prior to performance. 'Alpha' power prior to the high accuracy task showed significant differences mediated by the outcome. Successful performance was preceded by higher levels of 'alpha' power than unsuccessful attempts. The reported use of a cognitive strategy on the first task produced a significant difference in activity, lower alpha power being associated with the use of such a technique.  相似文献   

Court-dictated research: A new threat to academic freedom     

Herbert I. London 《Academic Questions》1988,2(1):7-9

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Until Proven Innocent: Political Correctness and the Shameful Injustices of the Duke Lacrosse Rape Case, by Stuart Taylor, Jr., and KC Johnson. New York: Thomas Dunne Books, 2007, 432 pp., $26.95 hardbound.     

Michael I. Krauss 《Academic Questions》2008,21(1):114-121

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The great fires of 1871 in the Northwest     

I.A. Lapham 《Journal of The Franklin Institute》1872,93(6):413-417

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The road to educational reform in the USSR     

Mikhail I. Kondakov 《Prospects》1987,17(1):27-35

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