Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Recording the war effort: immigrant communities in Latin America and the memory of the Great War     

María Inés Tato 《档案与原稿》2020,48(2):200-215

ABSTRACT

This paper aims to analyse the initiatives undertaken by some immigrant communities residing in Latin America to record their mobilisation around the First World War. After the armistice, European communities in Argentina, Bolivia, Brazil, Chile, Mexico, Paraguay, Peru, Uruguay and other countries gathered detailed information about their activities during the conflict, published as profusely illustrated books of remembrance, offered to their governments as proof of their loyalty. The article intends to establish the peculiar nature of these publications as records of the war effort, and analyse the agents and processes of their elaboration, and their role as commemorative but also as archival documents.  相似文献   

The Clarke County (Alabama) War Memorial: Kairos and Chronos United in the Sacred Commemoration and Contemplation of Five Wars     

Alison I. English 《Journal of American culture (Malden, Mass. : 2003)》2004,27(4):384-405

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教练员与运动员关系的研究   总被引：7，自引：0，他引：7  

程云峰  姜丽  杨太胜  王阜存  李金珠  张晓蓬 《山西师大体育学院学报》2002,17(2):51-53

我国竞技体育,教练员与运动员关系好的不乏其人,他们努力训练,通力合作,为我国的竞技体育的腾飞作出了卓越的贡献,但也有些教练员与运动员关系不融洽,使运动员过早地离开运动场,失去了为国争光的机会。文章通过教练员和运动员关系的研究,旨在为提高竞技运动水平和教练员在选材、训练时提供参考。  相似文献   

健康——不可忽视的人力资本投资     

傅玲  白文飞 《首都体育学院学报》2002,14(3):27-28

健康作为一种人力资本投资对提高生产力、促进经济发展和个人发展有着重要的作用。它可以提高劳动者的生产效率，刺激教育方面的投资，使人具有更多的时间和能力利用其他资本要素，具有更大的财力（因减少医疗费用）用于其他方面的投资。所以进行人力资本投资时，不可忽视健康这一要素，它也是人力资本形成的重要途径，也对经济增长起着有力的推动作用。  相似文献   

Introduction: Scientific and Technological Textbooks in the European Periphery     

José Ramón Bertomeu-sánchez  Antonio García-Belmar  Anders Lundgren  Manolis Patiniotis 《Science & Education》2006,15(7-8):657-665

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Victor Mercante (1870–1934)     

Inés Dussel 《Prospects》1996,26(2):413-431

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The turning point in 1985. The history of appraisal and disposal of records in Iceland     

Kristjana Kristinsdóttir 《Archival Science》2003,3(2):199-204

The article sets off with a brief summary of the history of appraisal and disposal of records as processed at the National Archives of Iceland (NAI) since its establishment in 1882 to present times. Rules on appraisal and disposal of records introduced in 1900, 1911, and 1916 were ignored and all records were kept. Status quo remained until 1985 when a new National Archives Act was passed. The appraisal and disposal process adopted then is described and explained. It included the publication of instructions on records management as well as forms relating to records management. The influence of acts of law on the appraisal and disposal process is explained. Finally the experience with the arrangement of organised appraisal in Iceland is described.  相似文献   

Cerebral activity prior to motion task performance: an electroencephalographic study     

D Collins  G Powell  I Davies 《Journal of sports sciences》1991,9(3):313-324

Cerebral activity, as reflected by power in the alpha waveband (8-13 Hz), was examined prior to the performance of three tasks with different effort and accuracy requirements. The study aimed to further investigate changes in activity observed in an earlier study in which expert karate performers exhibited significant increases in alpha band power during preparation for a training task. In contrast to the earlier research, the high effort task produced a significant decrease in 'alpha' power prior to performance. 'Alpha' power prior to the high accuracy task showed significant differences mediated by the outcome. Successful performance was preceded by higher levels of 'alpha' power than unsuccessful attempts. The reported use of a cognitive strategy on the first task produced a significant difference in activity, lower alpha power being associated with the use of such a technique.  相似文献   

Court-dictated research: A new threat to academic freedom     

Herbert I. London 《Academic Questions》1988,2(1):7-9

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