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1.
Silvia Izquierdo álvarez Eva Barrio Ollero Francisco Miguel Llinares Sanjuan Fabiola Lorente Martínez María Teresa Calvo Martín 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2014,24(1):159-166
Introduction:
Additional nucleotide substitutions in the 3′-untranslated region of prothrombin gene could explain some thrombotic events and also adverse pregnancy outcomes. We describe the first case of a homozygous 20209C>T mutation as the cause of deep vein thrombosis in a Spanish patient.Case and methods:
The 56-year-old male patient with a partial tear of the Achilles tendon developed calf (tibial) deep vein thrombosis after immobilization and was treated with an anticoagulant. To determine if the deep vein thrombosis was of genetic origin, a peripheral blood DNA sample was analysed for the presence of the three most frequent mutations associated with thrombotic events: factor V Leiden (1691G>A), prothrombin (20210G>A) and methylene tetrahydrofolate reductase (677C>T). The presence or absence of the normal allele of prothrombin could not be determined using the PTH-FV-MTHFR StripAssay (Vienna Lab).Results:
Comprehensive analysis showed that the patient had a variant interfering with the polymerase chain reaction product, we sequenced the entire prothrombin gene and found that the patient had a homozygous C>T mutation at position 20209; this interfered with the polymerase chain reaction product, which needs a C at this position to be able to bind to the wild-type probe present in the test strip.Conclusion:
The homozygous 20209C>T mutation and the presence of the mutation 677C>T in heterozygosity explained the patient’s deep vein thrombosis because the combination of mutations would increase the risk of thrombosis. Suitable genetic counselling should be provided to the patient and first-degree relatives as it important to detect prothrombin gene variants that could increase risk for thrombotic events. 相似文献2.
The aim of this paper is to characterize the distribution of number of hits and spent time by web session. It also expects to find if there are significant differences between the length and the duration of a session with regard to the point of access–search engine, link or root. Web usage mining was used to analyse 17,174 web sessions that were identified from the webometrics.info web site. Results show that both distribution of length and duration follow an exponential decay. Significant differences between the different origins of the visits were also found, being the search engines’ users those who spent most time and did more clicks in their sessions. We conclude that a good SEO policy would be justified, because search engines are the principal intermediaries to this web site. 相似文献
3.
Susana Rojas Teresa Susinos Adelina Calvo 《International Journal of Inclusive Education》2013,17(2):156-173
This article seeks to illustrate how a research study that claims to be inclusive should incorporate into its development, decisions of methodological flexibility that enable voice to be given to all participants regardless of their personal conditions. The changes carried out in the techniques, procedures or in the kind of questions used in the research, illustrate how young persons can be involved in the building of scientific and academic knowledge that is being generated about them. This work forms part of a more extensive line of inquiry that started a number of years ago by two Spanish universities (Cantabria and Seville). 相似文献
4.
Elia Fernández-Díaz Carlos Rodríguez-Hoyos Adelina Calvo Salvador Gloria Braga Blanco Lorea Fernández-Olaskoaga Prudencia Gutiérrez-Esteban 《Educational Action Research》2019,27(3):362-378
ABSTRACTThis article focuses on the deconstruction of an inter-university action research project that has allowed us to rethink our teaching and research, questioning the social, political and ethical dimensions of the university. Following the pre-assembly proposal to promote participatory convergence, organized within the framework of the 1st Global Assembly for Knowledge Democracy (2017), an action research process was implemented in order to generate systematic inquiry around the current situation of the university and the need to act and rethink our commitment to promoting changes in this context. We have reflected on the meaning of democratization, rethinking the pedagogical relationship with our students and how we critically commit them to promote activism. We generated an environment where we look for the meaning of our practices by means of a visual narrative which has enabled us to weave and identify our own biography and become aware of where we are and why we act in one way or another. We have also focused on the search for the meaning of our actions in relation to the community we belong to and how to deal with the challenges of social justice, encouraging collaboration with other networks in a wider inter-university framework. 相似文献
5.
Sarah K. Howard Maryam Khosronejad Rafael A. Calvo 《European Journal of Engineering Education》2017,42(6):875-889
To be fully prepared for the professional workplace, Engineering students need to be able to effectively communicate. However, there has been a growing concern in the field about students’ preparedness for this aspect of their future work. It is argued that online writing tools, to engage numbers of students in the writing process, can support feedback on and development of writing in engineering on a larger scale. Through interviews and questionnaires, this study explores engineering academics’ perceptions of writing to better understand how online writing tools may be integrated into their teaching. Results suggest that writing is viewed positively in the discipline, but it is not believed to be essential to success in engineering. Online writing tools were believed to support a larger number of students, but low knowledge of the tools limited academics’ understanding of their usefulness in teaching and learning. Implications for innovation in undergraduate teaching are discussed. 相似文献
6.
Benedetto Lepori Vitaliano Barberio Marco Seeber Isidro Aguillo 《Journal of Informetrics》2013,7(3):622-634
This paper presents a comparative analysis of the structure of national higher education networks in six European countries using interlinking data. We show that national HE systems display a common core–periphery structure, which we explain by the lasting reputational differences in science, as well as the process of expansion and integration of HE systems. Furthermore, we demonstrate that centrality in national networks (coreness) is associated with organizational characteristics, reflecting that interlinking is motivated by access to resources and the status of the organizations concerned, and that national policies impact network structures by influencing the level of inequality in the distribution of resources and status. Finally, we show that, as an outcome of the core–periphery structure, the strength of ties between two HEIs is largely determined by their individual coreness, while the impact of distance is too small-scale to alter the network structure generated by organizational attributes. 相似文献
7.
The aim of this paper is to study the link relationships in the Nordic academic web space – comprised of 23 Finnish, 11 Danish and 28 Swedish academic web domains with the European one. Through social networks analysis we intend to detect sub-networks within the Nordic network, the position and role of the different university web domains and to understand the structural topology of this web space. Co-link analysis, with asymmetrical matrices and cosine measure, is used to identify thematic clusters. Results show that the Nordic network is a cohesive network, set up by three well-defined sub-networks and it rests on the Finnish and Swedish sub-networks. We conclude that the Danish network has less visibility than other Nordic countries. The Swedish one is the principal Nordic sub-network and the Finland network is a slightly isolated from Europe, with the exception of the University of Helsinki. 相似文献
8.
Peter McSweeney Joaquin Calvo Michael Santhanam‐Martin Helen Billman‐Jacobe 《Journal of Food Science Education》2017,16(3):77-80
Project work and work placements can help prepare tertiary food science students for the workplace. Programs in the curriculum should support the development of transferable skills such as communication, problem‐solving, and planning. This paper describes a case study of a new capstone project for Masters of Food Science students based on a work integrated learning model. Students were engaged to develop a HACCP plan for a cheesemaker. They interacted with a peer group, academics, and with professionals from the food industry. Two iterations of the project were completed. Staff and student feedback from the first iteration informed modifications in the subsequent iteration. Industry partners and an authentic work task were key components of the project. The model could apply to a broad range of programs that require a capstone project in the curriculum. 相似文献
9.
Mirian Calvo Madeleine Sclater 《The International Journal of Art & Design Education》2021,40(1):232-250
Urgent societal challenges have led to unease in our socio‐cultural interactions and the production systems that underpin our lives. To confront such challenges, collaboration stands out as an essential approach in accomplishing joint goals and producing new knowledge. It calls for interdisciplinary methodologies such as co‐design, an approach capable of bridging multiple expertise. The core activities of co‐design are based on the premise of collaboration and on developing creative social environments. Yet achieving collaboration through co‐design is challenging as people need to understand each other, and develop trust and rapport. We argue that ‘informal‐mutual learning’ is central to building mutual understanding. This article explores how we create spaces for collaboration through co‐design by examining the social environments supporting them. It examines the value of collaboration and its impact upon participants within an action research project conducted in Scotland. We identified Cultural‐Historical Activity Theory (CHAT) as a suitable theoretical framework. It offers support for holistic inquiry into participation and learning. Its strength was in the attention that it pays to multi‐dimensional human interactions within the social environment. This led to an understanding of the concepts of boundary‐crossing and boundary space examined through a CHAT lens. The findings shed light on four designerly conditions supporting informal‐mutual learning when engaged in collaboration during co‐design situations: choreography and orchestration, aesthetics, playfulness, and quality and quantity of participation. The findings enable us to elaborate on the theorisation of boundary space, a theoretical space for the assemblage of multiple levels of expertise to achieve collaboration. 相似文献
10.
Silvia Cobo Serrano Rosario Arquero Avilés Gonzalo Marco Cuenca Brenda Siso Calvo 《The Journal of Academic Librarianship》2019,45(1):58-65
Currently, libraries and other information services are facing new professional challenges in relation to digitization policies and orphan works after the publication of European Directive 2012/28/EU on certain permitted uses of orphan works and Spanish Royal Decree 224/2016. This paper aims to analyse how Spanish library and information centres specialising in theatre and performing arts meet users' textual and non-textual information needs, by respecting copyright issues and being involved in a dynamic and digital environment. For this purpose, an online questionnaire, which was used as a methodological tool, was sent to library directors in February 2018. At the same time, some research questions based on orphan works and digitisation approaches are discussed in the paper, specifically in reference to graphic and audiovisual materials. 相似文献