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Background: Our previous studies revealed cyclicity in the incidence rate of skin malignant melanoma (SMM; ICD9, Dx: 172) in the Czech Republic (period T=7.50～7.63 years), UK (T=11.00 years) and Bulgaria (T=12.20 years). Incidences com-pared with the sunspot index Rz (lag-period dT= 2, 4, 6, 10 or 12 years) have indicated that maximal rates are most likely to appear on descending slopes of the 11-year solar cycle, i.e., out of phase. We summarized and explored more deeply these cyclic variations and discussed their possible associations with heliogeophysical activity (HGA) components exhibiting similar cyclicity. Methods: Annual incidences of SMM from 5 countries (Czech Republic, UK, Bulgaria, USA and Canada) over various time spans during the years 1964～1992 were analyzed and their correlations with cyclic Rz (sunspot number) and aa (planetary geomagnetic activity) indices were summarized. Periodogram regression analysis with trigonometric approximation and phase-correlation analysis were applied. Results: Previous findings on SMM for the Czech Republic, UK and Bulgaria have been validated, and cyclic patterns have been revealed for USA (T=8.63 years, P<0.05) and Canada (Ontario, T=9.91 years, P<0.10). Also, various 'hypercycles' were established (T=45.5, 42.0, 48.25, 34.5 and 26.5 years, respectively) describing long-term cyclic incidence patterns. The association of SMM for USA and Canada with Rz (dT= 6 and 7 years, respectively) and aa (dT=-10 and 9 years, respectively) was described. Possible interactions of cyclic non-photic influences (UV irradiation, Schumann resonance signal, low-frequency geomagnetic fluctuations) with brain waves absorbance, neuronal calcium dynamics, neuro-endocrine axis modulation, melatonin/serotonin disbalance and skin neuro-immunity impairment as likely causal pathways in melanoma appearance, were also discussed. Conclusion: The above findings on cyclicity and temporal association of SMM with cyclic environmental factors could not only allow for better forecasting models but also lead to a better understanding of melanoma aetiology. 相似文献
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摘要：宇宙观是影响一个思想体系及社会制度的重要因素，传统武术体系的形成与发展也离不开对古代宇宙观的认识。为丰富武术哲学体系，揭示中国古代宇宙观与传统武术形成之间的哲学基础，主要采用文献资料法，在古文献史料的基础上阐述古人从对宇宙认识，从中提取传统武术哲学之精华，认为传统武术哲学的形成前提是对宇宙的认识，并超越了神论限制,走向发展的正途；中国古代气论、道论、太极发生论、宇宙生命整体论影响着传统武术哲学的本质观、修炼境界观、平衡观和武术哲学的基本理念。该研究不仅说明武学产生的思想基础，丰富了武学的认识论体系，而且揭示了传统武术哲学的发展过程与规律，对我们认识武学体系的内在精髓提供启示和借鉴。 相似文献
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Brain metastases of melanoma mechanisms of attack on their defence system by engineered stem cells in the microenvironment 总被引：1，自引：1，他引：0
This report gives a better emphasis on the role of targeted effectors （e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone） and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers. 相似文献
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GEJZA M. TIMČÁK PETER KOŠĆ JURAJ PAŇKO 《European Journal of Engineering Education》1996,21(3):245-253
Electronic mail entered the Technical University Ko?ice in 1990. Now, instead of the few tens of users at the beginning, the system hosts thousands of them. Interactive teaching programmes as well as teaching programmes that are supported by audio and visual channels have also been used since 1990. The paper presents a short account of past development, the present situation and perspectives within the area of Internet use and of tuition that employs multimedia related means of teaching. 相似文献
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