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In the whole world, the internet is exercised by millions of people every day for information retrieval. Even for a small to smaller task like fixing a fan, to cook food or even to iron clothes persons opt to search the web. To fulfill the information needs of people, there are billions of web pages, each having a different degree of relevance to the topic of interest (TOI), scattered throughout the web but this huge size makes manual information retrieval impossible. The page ranking algorithm is an integral part of search engines as it arranges web pages associated with a queried TOI in order of their relevance level. It, therefore, plays an important role in regulating the search quality and user experience for information retrieval. PageRank, HITS, and SALSA are well-known page ranking algorithm based on link structure analysis of a seed set, but ranking given by them has not yet been efficient. In this paper, we propose a variant of SALSA to give sNorm(p) for the efficient ranking of web pages. Our approach relies on a p-Norm from Vector Norm family in a novel way for the ranking of web pages as Vector Norms can reduce the impact of low authority weight in hub weight calculation in an efficient way. Our study, then compares the rankings given by PageRank, HITS, SALSA, and sNorm(p) to the same pages in the same query. The effectiveness of the proposed approach over state of the art methods has been shown using performance measurement technique, Mean Reciprocal Rank (MRR), Precision, Mean Average Precision (MAP), Discounted Cumulative Gain (DCG) and Normalized DCG (NDCG). The experimentation is performed on a dataset acquired after pre-processing of the results collected from initial few pages retrieved for a query by the Google search engine. Based on the type and amount of in-hand domain expertise 30 queries are designed. The extensive evaluation and result analysis are performed using MRR, [email protected], MAP, DCG, and NDCG as the performance measuring statistical metrics. Furthermore, results are statistically verified using a significance test. Findings show that our approach outperforms state of the art methods by attaining 0.8666 as MRR value, 0.7957 as MAP value. Thus contributing to the improvement in the ranking of web pages more efficiently as compared to its counterparts.  相似文献   
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Hyperferritinemia (>10,000 ng/ml) is an important hallmark used as an indicator of infection triggered macrophage activation syndrome leading to hemophagocytic lympho histiocytosis (HLH). Measurement of serum ferritin can be used in diagnosis as well as disease monitoring indicator and prognosis related to HLH, cAPS, sepsis, neoplasm and inflammatory conditions. It is a major contributor to manage critically ill patients as predicting and monitoring indicator. It can be used as acute phase response in conditions of MAS, AOSD, cAPS etc. A case study in our hospital showed extremely high ferritin values along with low hemoglobin, elevated LDH and triglycerides with positive MRSA in sputum culture and macrophage proliferation and hemophagocytosis in the bone marrow examination. Patient showed definite inverse relation with steroid therapy and serum ferritin levels.  相似文献   
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The “free” in “free software” refers to a cluster of four specific freedoms identified by the Free Software Definition. The first freedom, termed “Freedom Zero,” intends to protect the right of the user to deploy software in whatever fashion, towards whatever end, he or she sees fit. But software may be used to achieve ethically questionable ends. This highlights a tension in the provision of software freedoms: while the definition explicitly forbids direct restrictions on users’ freedoms, it does not address other means by which software may indirectly restrict freedoms. In particular, ethically-inflected debate has featured prominently in the discussion of restrictions on digital rights management and privacy-violating code in version 3 of the GPL (GPLv3). The discussion of this proposed language revealed the spectrum of ethical positions and valuations held by members of the free software community. In our analysis, we will provide arguments for upholding Freedom Zero; we embed the problem of possible uses of software in the broader context of the uses of scientific knowledge, and go on to argue that the provision of Freedom Zero mitigates against too great a moral burden—of anticipating possible uses of software—being placed on the programmer and that, most importantly, it facilitates deliberative discourse in the free software community.  相似文献   
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Osteoarthritis of knee joints is a disease of old age in both sex. It is very common after the age of 40 years in elderly females or in postmenopausal phase of females. It is characterized by narrowing of space in joints due to inflammation. The exact mechanism of inflammation in this disease is not yet clear. Tumor necrosis factor alpha (TNF-α) may involve in onset of disease. The present study is being carried out in 130 female subject of age group 40–60 years suffering from osteoarthritis of knee joints and 50 normal healthy control female subjects. A correlation is made between TNF-α and estrogen and found significant inverse correlation (r<0.001), between TNF-α and estrogen hormone in osteoarthritic female patients as compared to normal healthy control female group.  相似文献   
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The burden of disease in patients with congestive heart failure is high. The future of BNP looks promising as it may be a better diagnostic tool for the diagnosis of CHF in developing countries in new millennium. Natriuretic peptide hormones, a family of vasoactive peptides with many favourable physiological properties, have emerged as important contenders for development of diagnostic tools and therapeutic agents in cardiovascular disease. Measurement of B-type natriuretic peptide has become as an easy-to-perform bedside test. The clinical and diagnostic significance of the measurement of plasma Nt-proBNP in the diseases of the cardiovascular system with particular emphasis on the assessment of patients with heart failure and their effects on predicting survival rate. The plasma levels of Nt-proBrain Natriuretic peptide responds more vigorously after myocardial infarction than those of other natriuretic peptides. This article is an attempt to give a short overview on the utility of BNP-blood levels for the diagnosis and treatment of heart failure  相似文献   
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Early years is the period of rapid physical and mental growth wherein the foundation for the child's development is laid and therefore, these years are considered extremely critical for the overall development of the child. Given the critical significance of these early childhood years, it is imperative for every child to get the opportunity to develop in a stimulating environment. The early childhood programmes provide this stimulating environment to the children. Extensive research evidence indicates towards the positive impact of early intervention and both short-term and long-term gains of an early childhood programme. However, mere participation in an early childhood programme is not sufficient. The quality of the programme attended by the children at this stage is also crucial. The various provisions provided by the programme to the children determine the quality of an early childhood programme. Curriculum seems to be the basic variable that influences the provisions provided to children in an Early Childhood Care and Education programme and in turn determines the quality of the programmes for children. This article is an attempt to study the variability of provisions provided and curriculum implemented in different early childhood programmes.  相似文献   
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