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Suparna Dhara Anindya Dasgupta Jayanta Kumar Rout Ushasi Banerjee Sayantan Dasgupta Arindam Ghosh 《Indian journal of clinical biochemistry : IJCB》2015,30(1):99-103
Psoriasis is a chronic inflammatory disease associated with an increased insulin resistance, obesity and cardiovascular risk. The present study was aimed to assess insulin resistance and pattern of body fat deposition in psoriasis. Body mass index (BMI) and waist circumference (WC) were measured in 40 psoriatic patients and 46 age- and sex-matched control subjects. Fasting blood glucose (FBG) and serum insulin level were measured by standard photometric method and ELISA respectively. HOMA-IR (homeostatic model of insulin resistance) was calculated by appropriate software. The results indicated that case and control groups were comparable in terms of age and sex (p = 0.934) with an increased prevalence of psoriasis among male subjects (60 %). FBG and mean WC between the two groups were statistically not significant (p value = 0.271 and 0.21 respectively). BMI was significantly higher in case group compared to the control group (p = 0.049). Serum insulin level and insulin resistance in the psoriatic patients were significantly higher (p value <0.001). Multiple regression analysis revealed that insulin resistance (measured by HOMA) was dependent on BMI and WC at a significance level of p < 0.001 and 0.043 respectively. Therefore, the psoriatic patients in this region have significantly high amount of fasting serum insulin level along with an increased IR though their FBG level remains normal. Furthermore, these abnormalities are significantly dependent on total body fat as well as abdominal fat deposits. We suggest that psoriatic patients need to be evaluated for metabolic syndrome and managed accordingly. 相似文献
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Suparna Roy Ushasi Banerjee Anindya Dasgupta 《Indian journal of clinical biochemistry : IJCB》2016,31(1):43-49
In conjunction with thyroxine, bilirubin may play an important role for regulation of hsCRP level and a consequent pro-inflammatory condition in hypothyroidism. In present study we evaluated the dependence of hsCRP changes on total bilirubin (BT) and fT4 level in thirty overt (OH) and thirty subclinical hypothyroidism (SH). Serum BT, hsCRP, thyroxine and TSH were measured in both groups and compared with forty control subjects. Serum values of TSH, hsCRP showed raised (P < 0.001 for both) values with lower levels for fT4 and BT (P < 0.001 and 0.03 respectively) in hypothyroid patients compared to the controls. ANOVA showed significant increments in TSH and hsCRP values with decreases in fT4 among the control, SH and OH groups respectively (P < 0.001). BT values showed decrease in OH group only in comparison to controls (P = 0.04). Regression analysis revealed that hsCRP was negatively dependent on fT4 (β = −0.35, P = 0.002) and serum bilirubin (β = −0.40 and P < 0.001 respectively). Univariate general linear model analysis showed this dependence persisted even when carried out distinctly in SH and OH groups separately (P < 0.001). TSH did not show any significant predictive value on the hsCRP level in either of these two tests. From these analyses we suggest that serum hsCRP is closely integrated to a lowered synthesis of bilirubin and fT4 in hypothyroid patients. Furthermore, this causal relationship is not only limited to overt but also extends to the SH. 相似文献
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Cindy E. Hmelo-Silver Rebecca Jordan Catherine Eberbach Suparna Sinha 《Instructional Science》2017,45(1):53-72
In this paper, we share results from a classroom intervention that used a conceptual representation to support reasoning about ecosystems. Engaging students in modeling allows them to make their ideas visible while being malleable and available for discussion, which enables students to make meaning out of systems. Further, the Components-Mechanisms-Phenomena (CMP) conceptual representation was designed to enable students to construct coherent mental models. Following our intervention, students deepened their understanding of ecosystem dynamics when compared to students who engaged in traditional instruction without use of the CMP conceptual representation. We discuss our results in terms of data that helped guide the design of the intervention and we describe a theoretical perspective that can be used to guide future instruction. 相似文献
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Madhur M. Goyal Devarshi U. Gajjar Dhara B. Patel Pradeep Sune Abhay R. Vasavda 《Indian journal of clinical biochemistry : IJCB》2009,24(4):375-380
Oxidative stress has been proposed as a common underlying mechanism of cataractogenesis. Experimental and observational data
suggest that micronutrients like vitamin C and vitamin E with antioxidant capabilities may retard the development of age-related
cataract. Effect of these factors on lens epithelium cells, center of lens metabolic activities, is not completely elucidated.
The aim of present study was to examine the effect of vitamin C and E on surgically removed lens epithelium cells of patients
with cataract. Capsulorhexis samples were collected from 170 patients, admitted for cataract surgery. Catalase specific activity
was estimated in lens epithelium cells with and without vitamin (C or E) treatment at different concentration for different
time duration. Student’s t-test was employed for data analysis. We observed that in ex-vivo condition, a) both vitamin C and
E bring about a decrease in catalase activity in lens epithelial cells. b) vitamin C showed toxic effect at high concentration.
c) 100μM was the optimum concentration at which both vitamins showed maximum antioxidant activity. It was concluded that both
vitamin C and E has direct effect on lens epithelium cells. At optimum concentration, they can reduce oxidative stress in
these cells thus can support to prevent or delay cataract development. 相似文献
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ABSTRACT— Adolescence is a time characterized by change—hormonally, physically, and mentally. We now know that some brain areas, particularly the frontal cortex, continue to develop well beyond childhood. There are two main changes with puberty. First, there is an increase in axonal myelination, which increases transmission speed. Second, there is a gradual decrease in synaptic density, indicating significant pruning of connections. These neural changes make it likely that cognitive abilities relying on the frontal cortex, such as executive functions and social-cognitive abilities, also change during adolescence. Here, we review recent research that has demonstrated development during adolescence of a variety of social-cognitive abilities and their neural correlates. 相似文献
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