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Magana Alejandra J. Elluri Sindhura Dasgupta Chandan Seah Ying Ying Madamanchi Aasakiran Boutin Mireille 《Journal of Science Education and Technology》2019,28(4):382-398
Journal of Science Education and Technology - In science and engineering education, the use of heuristics has been introduced as a way of understanding the world, and as a way to approach... 相似文献
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Suparna Dhara Anindya Dasgupta Jayanta Kumar Rout Ushasi Banerjee Sayantan Dasgupta Arindam Ghosh 《Indian journal of clinical biochemistry : IJCB》2015,30(1):99-103
Psoriasis is a chronic inflammatory disease associated with an increased insulin resistance, obesity and cardiovascular risk. The present study was aimed to assess insulin resistance and pattern of body fat deposition in psoriasis. Body mass index (BMI) and waist circumference (WC) were measured in 40 psoriatic patients and 46 age- and sex-matched control subjects. Fasting blood glucose (FBG) and serum insulin level were measured by standard photometric method and ELISA respectively. HOMA-IR (homeostatic model of insulin resistance) was calculated by appropriate software. The results indicated that case and control groups were comparable in terms of age and sex (p = 0.934) with an increased prevalence of psoriasis among male subjects (60 %). FBG and mean WC between the two groups were statistically not significant (p value = 0.271 and 0.21 respectively). BMI was significantly higher in case group compared to the control group (p = 0.049). Serum insulin level and insulin resistance in the psoriatic patients were significantly higher (p value <0.001). Multiple regression analysis revealed that insulin resistance (measured by HOMA) was dependent on BMI and WC at a significance level of p < 0.001 and 0.043 respectively. Therefore, the psoriatic patients in this region have significantly high amount of fasting serum insulin level along with an increased IR though their FBG level remains normal. Furthermore, these abnormalities are significantly dependent on total body fat as well as abdominal fat deposits. We suggest that psoriatic patients need to be evaluated for metabolic syndrome and managed accordingly. 相似文献
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Michael J. Shoemaker Jeffrey L. Wilt Rajkumar Dasgupta Ronald J. Oudiz 《Cardiopulmonary Physical Therapy Journal》2009,20(4):12-18
Purpose: To describe the benefits of a feasible, outpatient exercise training program on exercise tolerance and health-related quality of life (HRQL) in individuals with pulmonary arterial hypertension (PAH). Methods: Case report on two subjects recruited from a tertiary care pulmonary hypertension clinic. Subject 1 was a 50-year-old male with idiopathic PAH. Subject 2 was a 54-year-old female with a 20+ year history of scleroderma and 6-year history of PAH. Both subjects underwent exercise training 3 times per week for 6 weeks using a cycle ergometer at workloads progressing from 50% to 80% of peak workload. Outcomes were assessed using cardiopulmonary exercise testing, six-minute walk test (6MWT), and HRQL using the Chronic Respiratory Disease Questionnaire (CRQ) and the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR). Results: Both subjects made substantial improvements in oxygen consumption and workload at anaerobic threshold (improvements of 3.8 and 4.2 mL·kg−1·min,−1 26 and 18 W, respectively) and 6MWT distance (from 496 to 586m and 416 to 517m, respectively). Only Subject 1 made substantial improvements in peak oxygen consumption (from 16.0 to 18.3 mL·kg−1·min−1and from 15.0 to 15.6 mL·kg−1·min,−1 respectively) and peak work rate (from 112 to 130W and 66 to 69W, respectively). Both subjects demonstrated improved HRQL. No adverse events were noted. CONCLUSIONS: A short and practical exercise training program can improve measures of workload, aerobic capacity, and HRQL in individuals with PAH with no adverse effects shown in these two case studies.Key Words: pulmonary arterial hypertension, exercise training 相似文献
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Suparna Roy Ushasi Banerjee Anindya Dasgupta 《Indian journal of clinical biochemistry : IJCB》2016,31(1):43-49
In conjunction with thyroxine, bilirubin may play an important role for regulation of hsCRP level and a consequent pro-inflammatory condition in hypothyroidism. In present study we evaluated the dependence of hsCRP changes on total bilirubin (BT) and fT4 level in thirty overt (OH) and thirty subclinical hypothyroidism (SH). Serum BT, hsCRP, thyroxine and TSH were measured in both groups and compared with forty control subjects. Serum values of TSH, hsCRP showed raised (P < 0.001 for both) values with lower levels for fT4 and BT (P < 0.001 and 0.03 respectively) in hypothyroid patients compared to the controls. ANOVA showed significant increments in TSH and hsCRP values with decreases in fT4 among the control, SH and OH groups respectively (P < 0.001). BT values showed decrease in OH group only in comparison to controls (P = 0.04). Regression analysis revealed that hsCRP was negatively dependent on fT4 (β = −0.35, P = 0.002) and serum bilirubin (β = −0.40 and P < 0.001 respectively). Univariate general linear model analysis showed this dependence persisted even when carried out distinctly in SH and OH groups separately (P < 0.001). TSH did not show any significant predictive value on the hsCRP level in either of these two tests. From these analyses we suggest that serum hsCRP is closely integrated to a lowered synthesis of bilirubin and fT4 in hypothyroid patients. Furthermore, this causal relationship is not only limited to overt but also extends to the SH. 相似文献
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Sutirtha Chakraborty Anindya Dasgupta Harendra Nath Das Om Prakash Singh Asok Kumar Mandal Nikhiles Mandal 《Indian journal of clinical biochemistry : IJCB》2009,24(2):194-197
Oxidative stress has been found to play important role in several neuropsychiatric diseases including Obsessive Compulsive
Disorder. A longitudinal case control study was conducted to evaluate the oxidative stress in 30 newly diagnosed obsessive
compulsive disorder patients and same number of control patients. Serum thiobarbituric acid reacting substances, plasma ascorbate
were assessed to evaluate oxidative stress and Yale Brown obsessive compulsive scale for disease severity before and after
treatment with Fluoxetine at the average dosage of 40 mg/day. Improvement in Yale Brown obsessive compulsive scale score by
about 43% after 12 weeks treatment was associated with significantly decreased thiobarbituric acid reacting substances and
increased plasma ascorbate values (p < 0.05). The newly diagnosed obsessive compulsive disorder patients had higher serum
thiobarbituric acid reacting substances as well as a lower plasma ascorbate levels than the control population. Thus, the
present study suggested a significant role of oxidative stress in obsessive compulsive disorder and showed that a successful
treatment with Fluoxetine not only improves the clinical scenario but also reduces the oxidative stress that may further improve
the prognosis of the disease. 相似文献
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Sayantani Dasgupta 《About Campus》2012,17(4):19-23
Culture shock runs deep for this teacher from India. Sayantani Dasgupta's musings on education in New Delhi and Idaho reminds us of what we love (and love to hate!) about American higher education. 相似文献
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Sayantan Mandal 《International Journal of Lifelong Education》2013,32(2):190-208
In this era of globalisation, the present perception of lifelong learning (LLL) in the Indian policy domain has been going through major changes in an attempt to make it nationally realistic yet globally viable. In this process, all facets of the concept of LLL are constantly metamorphosing, and this in many ways outperforms the older perception of LLL in India. The main objective of the paper is to gain a better insight into this metamorphosis in three consecutive stages; from recommendations, to policies and finally to guidelines. It uses Peter Jarvis’s theoretical framework to analyse the tensions in reshaping the dimensions of LLL in a certain context, yet gives flexibility for new analytical inputs. Based on the analysis, it is possible to generalise two major perspectives of LLL in Indian policies; a competitive and skill-oriented one, which is more global in nature. The other possesses a traditional nature and addresses basic educational needs. The process of metamorphosis is going through a major transition phase while facing resistance from several levels. This encourages further research on the complexities of LLL at different levels and contexts to gain better insights. 相似文献
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It is essential to teach students about experimental design, as this facilitates their deeper understanding of how most biological knowledge was generated and gives them tools to perform their own investigations. Despite the importance of this area, surprisingly little is known about what students actually learn from designing biological experiments. In this paper, we describe a rubric for experimental design (RED) that can be used to measure knowledge of and diagnose difficulties with experimental design. The development and validation of the RED was informed by a literature review and empirical analysis of undergraduate biology students’ responses to three published assessments. Five areas of difficulty with experimental design were identified: the variable properties of an experimental subject; the manipulated variables; measurement of outcomes; accounting for variability; and the scope of inference appropriate for experimental findings. Our findings revealed that some difficulties, documented some 50 yr ago, still exist among our undergraduate students, while others remain poorly investigated. The RED shows great promise for diagnosing students’ experimental design knowledge in lecture settings, laboratory courses, research internships, and course-based undergraduate research experiences. It also shows potential for guiding the development and selection of assessment and instructional activities that foster experimental design. 相似文献