基于二模复杂网络的隐性知识发现方法研究——以潜在药物靶点挖掘为例     

李东巧  陈芳  韩涛  杨艳萍  王学昭  王燕鹏  Cynthia Liu  Yingzhu Li 《图书情报工作》2020,64(21):120-129

[目的/意义] 通过构建二模复杂网络模型，揭示隐藏在海量文献中的隐性知识。[方法/过程] 通过NetworkX复杂网络工具包，依据任意两个节点的共现关系构建二模复杂网络模型；对网络模型中节点的共现关系进行加权，计算网络的拓扑信息并进行AP聚类，提取节点间的直接关系；采用AUC方法对AA、JC、加权改进的wAA和wJC等4种链路预测算法进行评价，遴选出最合适的预测算法，并对复杂网络的隐性关系进行预测分析。[结果/结论] 以潜在药物靶点挖掘为例进行的实证研究结果表明，wAA链路预测算法为最优的链路预测算法；二模复杂网络模型、指标和方法体系在美国化学文摘社数据库中的药物靶点挖掘中具有一定的有效性。下一步计划在其他数据库中或其他研究领域中进行尝试，以进一步验证该模型的通用性和有效性。  相似文献   

Computer Technology,Science Education,and Students with Learning Disabilities     

Kumar  David  Wilson  Cynthia L. 《Journal of Science Education and Technology》1997,6(2):155-160

The ways computer technology could be used to teach science to students with learning disabilities (LD) are explored. Science is for all students and that includes students with LD. Learning science has both cognitive and affective implications for students with LD. In this context, computer technology provides cognitively engaging and motivating instructional tools for individualizing the mode of delivery; developing expert tutors; anchoring instruction; integrating science with other subjects; reducing cognitive load on working memory; and motivating students to stay on task. These applications are discussed with implications for teaching science to students with LD.  相似文献   

From a child's point of view: Studying Thailand and Nigeria     

Cynthia Szymanski Sunal  Barbara Gibson Warash 《Early Childhood Education Journal》1992,19(3):4-8

Young children enjoy studying about other cultures when they experience them in a concrete, hands-on manner. Cross-cultural study by young children should encourage them to experience a culture from an indigenous child's viewpoint. Learning facts and information about a culture is less important than experiencing how children from other places might play a game or what they might eat for dinner.Cynthia Szymanski Sunal is a professor of early childhood education and a social studies specialist at the University of Alabama. Barbara Gibson Warash is a clinical Associate Professor and Director of the Laboratory Preschool at West Virginia University.  相似文献   

Games online students play:     

Cynthia Seguin 《TechTrends》2002,46(4):23-28

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Anatomy as a Model Environment for Acquiring Professional Competencies in Medicine: Experiences at Harvard Medical School     

Katherine G. McDaniel  Taylor Brown  Caitlin C. Radford  Cynthia H. McDermott  Trudy van Houten  Martha E. Katz  Dana A. Stearns  Sabine Hildebrandt 《Anatomical sciences education》2021,14(2):241-251

Anatomy education provides students with opportunities to learn structure and function of the human body, to acquire professional competencies such as teamwork, interpersonal skills, self-awareness, and to reflect on and practice medical ethics. The fulfillment of this wide potential can present challenges in courses that are part of an integrated curriculum and shorter than traditional courses. This new reality, together with students' increasing concern about the stresses within medical education, led to efforts at Harvard Medical School to implement practical steps toward an optimal learning environment in anatomy. These were based on core elements of ethical anatomy education and principles of trauma-informed care. Anatomy is conceptualized here as the “first clinical discipline,” with relational interactions between anatomical educators, medical students, and body donors/patients. Essential prerequisites for the implementation of this work were support by the medical school leadership, open partnership between engaged students and faculty, faculty coordination, and peer-teaching. Specific interventions included pre-course faculty development on course philosophy and invitations to students to share their thoughts on anatomy. Student responses were integrated in course introductions, combined with a pre-dissection laboratory visit, an introductory guide, and a module on the history and ethics of anatomy. During the course, team-building activities were scheduled, and self-reflection encouraged, for example, through written exercises, and elective life-body drawing. Students' responses to the interventions were overall positive, but need further evaluation. This first attempt of a systematic implementation of an optimal learning environment in anatomy led to the identification of areas in need of adjustment.  相似文献   

Realizing General Education: Reconsidering Conceptions and Renewing Practice     

Cynthia A. Wells 《ASHE Higher Education Report》2016,42(2):1-85

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Development of a taxonomy of keywords for engineering education research     

Cynthia J. Finelli  Maura Borrego  Golnoosh Rasoulifar 《European Journal of Engineering Education》2016,41(3):231-251

The diversity of engineering education research provides an opportunity for cross-fertilisation of ideas and creativity, but it also can result in fragmentation of the field and duplication of effort. One solution is to establish a standardised taxonomy of engineering education terms to map the field and communicate and connect research initiatives. This report describes the process for developing such a taxonomy, the EER Taxonomy. Although the taxonomy focuses on engineering education research in the United States, inclusive efforts have engaged 266 individuals from 149 cities in 30 countries during one multiday workshop, 7 conference sessions, and several other virtual and in-person activities. The resulting taxonomy comprises 455 terms arranged in 14 branches and 6 levels. This taxonomy was found to satisfy four criteria for validity and reliability: (1) keywords assigned to a set of abstracts were reproducible by multiple researchers, (2) the taxonomy comprised terms that could be selected as keywords to fully describe 243 articles in 3 journals, (3) the keywords for those 243 articles were evenly distributed across the branches of the taxonomy, and (4) the authors of 31 conference papers agreed with 90% of researcher-assigned keywords. This report also describes guidelines developed to help authors consistently assign keywords for their articles by encouraging them to choose terms from three categories: (1) context/focus/topic, (2) purpose/target/motivation, and (3) research approach.  相似文献   

The Effect of Relationship on Children's Distributive Justice Reasoning     

Ann V. McGillicuddy-De Lisi  Cynthia Watkins  rew J. Vinchur 《Child development》1994,65(6):1694-1700

Kindergarten, third-grade, and sixth-grade children were told 2 stories about a group of children who made artwork that was subsequently sold at a craft fair. The characters in one story were described as friends, while the characters in the other story were described as strangers (relationship condition). 1 character in each story was presented as the oldest in the group, 1 as the most productive, and 1 as the poorest. Children were asked to allocate 9 dollars to the 3 characters under each relationship condition, provide rationales for those allocations, and rate the fairness of 4 different patterns of allocation. Older children allocated more money to needy friends than to needy strangers and more to productive strangers than to productive friends. Kindergartners' allocations and fairness ratings did not vary with relationship. Rationales for allocation judgements suggested that equality was the most salient principle for decisions at all ages, but the older children provided rationales based on benevolence more often than younger children when characters were presented as friends.  相似文献   

Neonatal Stress Reactivity: Predictions to Later Emotional Temperament   总被引：1，自引：0，他引：1  

Megan R. Gunnar  Fran L. Porter  Cynthia M. Wolf  Joseph Rigatuso  Mary C. Larson 《Child development》1995,66(1):1-13

To investigate the relations among popular measures of neonatal stress and their link to subsequent temperament, 50 full-term newborns from a normal care nursery were examined responding to a heelstick blood draw. Baseline and heelstick measures of behavioral state, heart period, vagal tone, and salivary cortisol were obtained. Recovery measures of behavioral and cardiac activity were also analyzed. Mothers completed Rothbart's Infant Behavior Questionnaire when their infants reached 6 months of age. Baseline vagal tone predicted cortisol in response to the heelstick, suggesting that baseline vagal tone reflects the infants' ability to react to stressors. Greater reactivity to the heelstick (more crying, shorter heart periods, lower vagal tone, and higher cortisol) was associated with lower scores on "Distress-to-Limitations" temperament at 6 months. This finding was consistent with the expectation that the capacity to react strongly to an aversive stimulus would reflect better neurobehavioral organization in the newborn. Recovery measures of cardiac activity approximated and were correlated with baseline measures indicating the strong self-righting properties of the healthy newborn. Finally, vagal tone and salivary cortisol measures were not significantly related, suggesting the importance of assessing both systems in studies of the ontogeny of stress-temperament relations.  相似文献   

I. Introduction     

Joseph Jaffe  Beatrice Beebe  Stanley Feldstein  Cynthia L. Crown  & Michael D. Jasnow 《Monographs of the Society for Research in Child Development》2001,66(2):1-7

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