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Drawing on anniversary-edition articles and interviews with journalists at Jakarta Post, Indonesia’s largest English-language news outlet, we argue that language of publication directly informs the narratives a journalistic interpretive community [Zelizer, Barbie. 1993. “Journalists as Interpretive Communities.” Critical Studies in Mass Communication 10: 219–237] develops to position itself as a news authority. Analysis showed that associations with English as a foreign language in Indonesia influenced stories of the newspaper’s professional values and practice, and the ways it conceptualized readership. The study contributes to the growing body of literature that examines intersections of journalism and language—in this case, English as a language of publication in a global context. 相似文献
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M. Swarna M. Sujatha P. Usha Rani P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2004,19(2):163-167
Recent studies have presented evidence for the involvement of L1CAM gene mutations in various X-linked mental retardation
syndromes. The neural cell adhesion molecule, L1CAM is a transmembrane protein belonging to the super family of the immunoglobulins
that play a key role in embryonic development of the nervous system and is involved in memory and learning. No studies were
carried out from India on L1 CAM gene in X-linked mental retardation syndromes. Hence, an investigation was taken up to delineate
the role of L1CAM gene in mental retardation.
Two families (Family I and Family II) having only two members affected with mental retardation in each family were studied
for mutations in L1CAM gene. In family II, the younger sibling showed deletion involving region between the nucleotide 13,773
(intron 25) and 14,158 (intron 27) region. The mutation what we observed in younger sibling of the family II is a novel mutation
which was not hitherto reported in the world literature. 相似文献
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This section features conversations with personalities related to science, highlighting the factors and circumstances that guided them in making the career choice to be a scientist. 相似文献
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Murali Krishna Madisetty Konda Kumaraswami Shivakrishna Katkam Kankanala Saumya Y. Satyanarayana Raju Naval Chandra Maddury Jyotsna Sujatha Patnaik Vijay Kumar Kutala 《Indian journal of clinical biochemistry : IJCB》2016,31(3):278-285
We aimed to assess whether measuring carotid intima-media thickness (CIMT) and oxidative stress markers such as protein carbonyls, malondialdehyde, nitrate and glutathione in plasma of elderly patients without and with coronary artery disease (CAD) identifies early risk for CAD. A total of 50 cases with cardiovascular risk factors over the age of 60 years without CAD, and 50 patients with angiographically documented CAD over the age of 60 years were included in the study. Control group consists of 200 healthy individuals without the risk factors. Demographic details were obtained from all the subjects and CIMT measured by high frequency ultrasound and oxidative stress markers such protein carbonyls, malondialdehyde and total glutathione were determined in plasma by spectrophotometric methods. The distribution of cardiovascular risk factors in without CAD and CAD cases were smokers (16 vs 56 %), hypertension (26 vs 64 %), diabetes (16 vs 56 %) and dyslipidemia (18 vs 58 %) and positive family history (4 vs 38 %). None of the control group had any cardiovascular risk factors. Among the CAD cases, 16 % had single vessel disease, 44 % had double vessel disease and 40 % had triple vessel disease. The CIMT was significantly increased in CAD cases as compared to cases without CAD and healthy controls. On the other hand, CIMT was significantly increased in cases without CAD as compared to healthy controls. CIMT also increased with the duration of diabetes in patients without CAD and severity of disease in CAD cases. The levels of oxidants like plasma malondialdehyde, protein carbonyls, were significantly elevated and antioxidant glutathione levels and nitrate levels were significantly reduced in cases with and without CAD as compared to healthy controls. Oxidative stress markers and CIMT was found to be significantly increased in patients with cardiovascular risk factors like diabetes, family history of CAD, dyslipidemia, hypertension and smoking when compared to patients without risk factors. In patients with diabetes, CIMT increased as duration of disease increases and also in poorly controlled diabetes. In CAD group, when number of vessel involvement (severity of coronary disease) increases, the CIMT also increases confirming that CIMT is a quantifiable risk factor for CAD. 相似文献
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Sujatha Baskaran Vani Brahmachari 《Indian journal of clinical biochemistry : IJCB》2000,15(1):145-157
The first report of X-linked mental retardation correlated with the presence of marker chromosome came in 1940. It was in 1990 that the molecular basis of fragile X syndrome was deciphered. This elucidation marked the discovery of a novel process of mutation designated as dynamic mutations, resulting in the expansion of a triplet repeat sequence within the human genome. Subsequently several human genetic disorders involving triplet repeat expansion have been discovered. Almost all the disorders are known to affect the nervous system and/or the brain. This review presents an overview of fragile sites in the genome and the molecular genetics of fragile X syndrome. 相似文献
7.
Shilpa Reddy Ganasyam Talluri Bhaskar Rao Y. S. R. Murthy Akka Jyothy Madireddy Sujatha 《Indian journal of clinical biochemistry : IJCB》2012,27(1):69-73
Type 2 diabetes mellitus (DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis.
Estrogen plays an important role in type 2 DM pathogenesis. A number of polymorphisms have been reported in the estrogen receptor
(ESR1), including the XbaI and PvuII restriction enzyme polymorphisms of ESR1,which may be involved in disease pathogenesis. Metallothioneins (MT) act as potent
antioxidants against various oxidative damages. Very few studies have indicated the association between Estrogen Receptor-α,
MT1 gene polymorphisms with type2 DM. A total of 100 type 2 diabetic women and 100 age, sex matched controls were recruited.
Using the PCR based RFLP method, the PvuII and XbaI polymorphisms of ESR1 and in MT1A (rs8052394 and rs11076161) gene polymorphisms were analysed. The genotype distribution and frequency of mutated allele showed no significant differences
between diabetic and non-diabetic groups in PvuII (χ2 = 2.443; P = 0.1181) or XbaI (χ2 = 1.789; P = 0.1812) and rs8052394 (χ2 = 1.154; P = 0.2840) or rs11076161 (χ2 = 0.4141; P = 0.5199), polymorphisms. This is the first Indian study to conclude that ESR1 and MT1 gene polymorphisms are not associated
with increased susceptibility to type 2 diabetes in Indian women. 相似文献
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K. Sudhakar M. Sujatha S. Ramesh Babu P. Padmavathi P. P. Reddy 《Indian journal of clinical biochemistry : IJCB》2004,19(1):21-23
Calcium plays an important role in the pathophysiology of essential hypertension. Serum calcium levels were measured in 117
subjects with essential hypertension and 77 first-degree relatives. The results showed that serum calcium levels were significantly
(p<0.01) decreased in both males and females with essential hypertension and their first-degree relatives when compared with
the normotensive controls. This is the first study in Indian population. 相似文献
10.
Leventhal JM Larson IA Abdoo D Singaracharlu S Takizawa C Miller C Goodman TR Schwartz D Grasso S Ellingson K 《Child abuse & neglect》2007,31(3):311-322
OBJECTIVE: To determine whether the proportion of fractures rated as abusive in children <36 months of age evaluated at a regional pediatric hospital increased over a 24-year period from 1979 to 2002. Fractures were chosen as an example of serious injuries in young children. METHODS: Medical records were abstracted for all children <36 months of age who were seen at a single pediatric hospital with a fracture during three time periods: 1979-1983, 1991-1994, and 1999-2002. After reviewing the abstracted and radiographic information, two clinicians (one an expert on child abuse) and two pediatric radiologists each rated the likelihood of abuse using explicit criteria and a seven-point scale from definite abuse to definite unintentional injury. Ratings were done independently; when disagreements occurred, the case was discussed, and a joint rating was agreed upon, if possible. The proportions of cases rated as abuse were compared over the three time periods, and logistic regression was used to calculate adjusted odds ratios (OR). RESULTS: In the early, middle, and late samples, there were 200, 240, and 232 children, respectively, with fractures. The proportion of cases rated as abuse decreased from 22.5% in the early period to 10.0% in the middle period and was 10.8% in the late period (p<.001). When comparing the odds of abuse in the middle and late groups to the odds of abuse in the early group (controlling for age, gender, ethnicity, type of medical insurance, and site of pediatric care), the adjusted ORs were .31 (95% CI=.15, .62) for the middle group and .45 (95% CI=.23, .86) for the late group. Thus, the odds of a given case being rated as abuse decreased by over 50% from the early period to the middle and late time periods. No statistically significant difference was found when comparing the odds of abuse for the middle group to those of the late group, OR: 1.46 (95% CI=.69, 3.08). CONCLUSIONS: The proportion of abusive fractures in young children decreased substantially from 1979-1983 to 1991-1994 and 1999-2002 at a major pediatric hospital. We speculate that this decrease may reflect early recognition of less serious forms of maltreatment and the availability of services to high-risk families. 相似文献