排序方式： 共有36条查询结果，搜索用时 187 毫秒
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利用液相法合成了侧链带双羟基且具有C2 对称性的环二肽C_[L_Ser_L_Ser]并将其作手性配体催化不对称的Reformatsky反应。考察了反应底物结构以及反应条件等因素对反应产物e.e.值的影响。产物的e.e.值最高达 64%。提出了可能的反应机理 相似文献
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首次合成了一个新的合流Schiff减型有机配体──S─苄基─β─N─（N─氧化吡啶基）双（亚甲基肼基二硫代甲酸酯）（SBPBDH_2）,并通过熔点、元素分析、红外光谱等方法对其性质进行了测定,结果使其金属配合物的合成及应用的进一步研究成为可能． 相似文献
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近年来，H2O2被用来作为氧源是因为其合理的稳定性，迅速有效性，廉价经济和绿色环保(副产物只有水)。H2O2与廉价的、相对无毒的金属催化剂相结合的环氧化系统。在廉价生产和具体合成研究上具有很重要的意义。综述了简单金属盐类、金属卟啉类配合物和金属Salen类配合物以H2O2为氧化剂催化环氧化烯烃的研究进展。 相似文献
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以便宜易得α-呋喃甲醛为原料,经Cannizzaro歧化反应制得α-呋喃甲酸,氯化亚砜氯代生成α-呋喃甲酰氯,然后再与L-脯氨醇反应,最终得到新的具有双官能团的吡咯环骨架手性配体,该手性配体的结构经IR,1H NMR和GC-MS等物理手段进行了确证. 相似文献
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Bingyu SUN Yongqiang LIU Danhua HE Jinke LI Jiawei WANG Wulin WENS Ming HONG 《Journal of Zhejiang University. Science. B》2021,22(3):190-203
The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments.Most current chemotherapy agents have significant cytotoxicity,which leads to devastating adverse effects and results in a substandard quality of life,including increased daily morbidity and premature mortality.The death receptor of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells.However,various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways.Therefore,it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL,and to reinforce TRAIL’s ability to induce tumor cell apoptosis.In recent years,traditional Chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines.This review aims to collate information about Chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL’s ability to induce apoptosis.We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anticancer drugs for human cancer treatment.This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed."TRAIL sensitize"and"Chinese medicine"were the search keywords.We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis.The name of each plant was validated using certified databases such as The Plant List.This study indicates that TRAIL can be combined with different Chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis.It also demonstrates that the active ingredients of traditional Chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis.This provides useful information regarding traditional Chinese medicine treatment,the development of TRAIL-based therapies,and the treatment of cancer. 相似文献
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综述了绿色合成己二酸的研究现状,主要从催化剂的选择、配体的优化、相转移催化剂的取舍、机理的探索等方面来阐述,最后指出了存在的问题及应用前景. 相似文献
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以二茂铁为原料,经金属锂试剂锂化,亲核取代和硫醚的不对称氧化反应高光学纯地合成了手性二茂铁亚砜配体,其结构经红外光谱,核磁共振谱和质谱等物理手段进行了表征,并测定了该配体的ee值. 相似文献
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咪唑啉I2受体是一种非G蛋白偶联受体,其生理功能及临床意义目前尚不十分清楚。近年大量研究表明I2受体通过相关配体介导多种行为学效应。激活咪唑啉I2受体可能产生镇痛、抗抑郁、调节阿片受体功能、神经元保护等多种药理学作用。该文着重介绍了I2受体的分布、细胞定位、分子结构、信号转导、内源性配体和选择性配体及其相关神经药理学效应的研究进展。 相似文献
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Shailendra Kapoor 《Journal of Zhejiang University. Science. B》2009,10(3):242-242
The article "Cationic liposome-mediated trans-fection of CD40 ligand gene inhibits hepatic tumor growth of hepatocellular carcinoma in mice" [doi:10. 1631/jzus.B0820178] by Jiang et a1.(2009) in a recent issue of the Journal of Zhejiang University SCIENCE B was highly thought provoking. The authors have clearly demonstrated the efficacy of CD40 ligand gene therapy in inhibiting the growth of hepatocellu-lar carcinomas. The findings of Jiang et al.(2009) are highly important as they further support and cor-roborate the rapidly expanding role of CD40 ligand gene therapy in the management of systemic malig-nancies besides hepatocellular carcinomas. 相似文献
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