Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

吸烟对体育专业学生染色体损伤的研究   总被引：2，自引：0，他引：2  

吴鲁平 《北京体育大学学报》2003,26(3):343-344

用染色体畸变(CA)试验和胞质阻断微核(CBMN)试验评价了体育专业学生吸烟所诱发的染色体损伤。研究结果表明:吸烟组的平均染色体畸变率(1.0625%±0.998%)与对照组(0.5%±0.5164%)相比无显著差异。吸烟组的平均微核细胞率为11.56‰±4.289‰,明显高于对照组的4.375‰±1.962‰(P<0.01)。认为:微核试验结果表明体育专业吸烟学生外周血淋巴细胞的染色体已受到不同程度的损伤。  相似文献   

中国北方汉族青年ACE 基因I/ D多态性频率分布特征     

席翼  张秀丽  胡扬  刘刚  包大鹏  张海霞  吴建 《天津体育学院学报》2006,21(3):205-208

通过分析与探讨汉族普通人群ACE基因I／D多态频率分布特征，试图为中国优秀耐力运动员的基因选材研究提供中国人相关人群ACE基因I／D多态频率分布的基础数据。选择18-22岁汉族学生216名作为研究对象，观察其ACE基因I／D多态频率分布。结果显示：北方汉族青年的ACE基因I／D多态频率分布，与国内相关研究结果一致，与欧美人群有非常显著差异。研究认为：从种族单一性、样本数量和年龄段的选择等因素考虑．研究结果不仅可以作为北方汉族青年ACE基因I／D多态频率分布的代表，而且对于杰出耐力的多态性标记研究来讲是理想的对照群体。  相似文献   

探寻与运动能力有关的基因研究进展   总被引：2，自引：0，他引：2  

何子红 《天津体育学院学报》2001,16(4):12-19

对目前运动能力基因定位研究进展进行了综述.结果发现,与有氧能力有关的基因主要包括ACE、CKMM、ADRA2A及mtDNA的D-loop和MTND5,此外,家系研究提示1p、2p、4q、6p、8q、11p、14q染色体区域可能有与运动能力有关的基因;与肌肉力量有关的基因主要涉及GDF8、 CNTF.但这些基因的作用机制尚不清楚.同时,就今后研究趋势作了展望.  相似文献   

ACE基因多态性与有氧耐力运动关系研究   总被引：4，自引：0，他引：4  

甄文娟  谢盛  宋海宾 《乐山师范学院学报》2004,19(5):116-118

目前普遍认为ACE(血管紧张素转换酶)的水平和心血管的形态、功能密切相关。ACE基因的多态性是人耐力素质优劣的决定性因素之一。为了解运动员血管紧张素转换酶(ACE)基因插入或缺失(I/D）多态性情况，探讨ACE基因多态性与有氧耐力可能的关系，用聚合酶链反应(PCR)技术检测20例运动员和20例健康对照者的ACE基因多态性。结果位于ACE基因16内含子的L／D多态性经PCR扩增后呈三种基因型：纯合子插入型(II）、纯合子缺失型(DD)和杂合子插入或缺失型(ID)。耐力运动员组Ⅱ基因型和Ⅰ等位基因频率显著高于健康对照组。结果表明ACE基因可能在运动员的有氧耐力中起重要作用。  相似文献   

广西宜州市两种竹蝗的染色体C带核型研究(蝗总科:网翅蝗科)     

韦仕珍 《河池学院学报》2003,23(2):93-96

对分布在广西宜州市的竹蝗属CeracrisWalker两个种青脊竹蝗C .nigricornisnigricornisWalker和黑翅竹蝗C .fasciatafasciata(Brunnerv ,Wattenwgl)的核型和C带核型进行了研究。结果表明 :在染色体数目上、性别决定机制、染色体是端部着丝粒染色体和染色体都含有着丝粒C带带纹上具有一致性。染色体组式也相同 ,为 3L +7M +1S +X .但X染色体位置有着差异 ,两个种的C带带纹除着丝粒C带分布具有一致性外 ,其它类型的C带数量及分布都有着明显区别 ,2个种的异染色质含量差别也较大  相似文献   

兰州百合的核型分析   总被引：1，自引：0，他引：1  

李雪  朱彦荣  幸亨泰 《甘肃高师学报》2007,12(2):43-44

报道了兰州百合的染色体核型,其核型公式为2n=2X=24=2m(2SAT) 2sm 6st 14t,属于3A型,核型不对称性系数(As.K%)为81.37%。其中第一对染色体的短臂上具有居间随体。  相似文献   

Study of Resistin gene expression in peripheral blood mononuclear cell and its gene polymorphism in a small range population     

Yang YM  Xu ZR  Wu LJ  Huang WD 《Journal of Zhejiang University. Science. B》2007,8(2):132-135

INTRODUCTION Recently discovered as an endocrine organ, adi-pose tissue can secrete many cytokines such as Re-sistin, adiponectin and free fatty acids, and receives much attention in the study of insulin resistance and type 2 diabetes mellitus (T2DM). As a peptide hor-mone secreted by adipocyte, Resistin is considered to be the linkage between obesity and insulin resistance (Steppan et al., 2001). Most studies on Resistin in-vestigate adipose tissue. In this experiment we de-tected t…  相似文献   

Ultrabithorax is a key regulator for the dimorphism of wings,a main cause for the outbreak of planthoppers in rice     

Fangzhou Liu  Xiang Li  Muhua Zhao  Mengjian Guo  Kehong Han  Xinxin Dong  Jing Zhao  Wanlun Cai  Qifa Zhang  Hongxia Hua 《国家科学评论(英文版)》2020,7(7):1181

Rice planthoppers, the most devastating rice pests, occur in two wing forms: the short-wing form for rapid population growth and long-wing form for long-distance migration, which together create the mechanism for outbreak. Here we show that Ultrabithorax (Ubx) is a key regulator for switching between the long- and short-wing forms of rice planthoppers. Ubx is expressed in both forewing and hindwing pads, which is different from the canonical model of Ubx expression. In brown planthoppers, expression of Ubx (NlUbx) is regulated by nutritional status of the rice host. High-quality young plants induce NlUbx expression leading to the short-wing form; low-quality ripe plants reduce NlUbx expression resulting in long-wing form. We also showed that NlUbx is regulated by the insulin receptors NlInR1 and NlInR2. The default expression of NlInR1 inhibits NlUbx resulting in long-wings, while high-quality hosts induce NlInR2 expression, which represses NlInR1 thus promoting NlUbx expression to produce short-wings.  相似文献   

中国部分杨属植物的染色体数目     

张守攻  陈成彬  韩素英  李秀兰  任建中  周玉权  宋文芹  陈瑞阳  齐力旺 《中国科学院研究生院学报》2005,1(10):539-544

对中国杨属Populus L. 5组14种(银白杨P. alba L.、河北杨P. hopeiensis Hu & Chow、毛白杨P. tomentosa Carr.、欧洲山杨P. tremula L.、小叶杨P. simonii Carr.、辽杨P. maximowiczii Henry、大青杨 P. ussuriensis Kom. 、青杨P. cathayana Rehd.、小青杨P. pseudo-simonii Kitag.、香杨P. koreana Rehd.、毛果杨P. trichocarpa Torr. & Grog.、大叶杨P. lasiocarpa Oliv.、欧洲黑杨P. nigra L.、胡杨P. euphratica Oliv.),3变种(新疆杨P. alba L. var. pyramidalis Bge.、箭秆杨P. nigra L. var. thevestina Bean.、钻天杨P. nigra L. var. italica (moench.) Koehne),3杂交种(小钻杨P.×xiaozhuanica W. Y. Hsu & Liang、北京杨P.×beijingensis W. Y. Hsu、加杨P.×canadensis Moench、晚花杨P.×canadensis Moench cv. “serotina” 、沙兰杨P.×canadensis Moench cv. “Sacrau 79”和意大利214杨P.×canadensis Moench cv. “I-214”)进行了染色体计数。发现白杨组的毛白杨P. tomentosa Carr. 、 黑杨组的沙兰杨P. ×canadensis Moench cv. “Sacrau 79”和意大利214杨P. × canadensis Moench cv. “I-214”为三倍体(2n=3x=57),其余均为二倍体(2n=2x=38)。  相似文献